LupalbigeninCAS# 76754-24-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 76754-24-0 | SDF | Download SDF |
| PubChem ID | 10001388 | Appearance | Yellow powder |
| Formula | C25H26O5 | M.Wt | 406.5 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,7-dihydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-6-(3-methylbut-2-enyl)chromen-4-one | ||
| SMILES | CC(=CCC1=C(C=CC(=C1)C2=COC3=CC(=C(C(=C3C2=O)O)CC=C(C)C)O)O)C | ||
| Standard InChIKey | HTAZIHDXIUPDQP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C25H26O5/c1-14(2)5-7-17-11-16(8-10-20(17)26)19-13-30-22-12-21(27)18(9-6-15(3)4)24(28)23(22)25(19)29/h5-6,8,10-13,26-28H,7,9H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins. 2. Lupalbigenin, laburnetin , and isolupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM). |
| Targets | ERK | Akt | Topoisomerase | NO | Bcl-2/Bax |
Lupalbigenin Dilution Calculator
Lupalbigenin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.46 mL | 12.3001 mL | 24.6002 mL | 49.2005 mL | 61.5006 mL |
| 5 mM | 0.492 mL | 2.46 mL | 4.92 mL | 9.8401 mL | 12.3001 mL |
| 10 mM | 0.246 mL | 1.23 mL | 2.46 mL | 4.92 mL | 6.1501 mL |
| 50 mM | 0.0492 mL | 0.246 mL | 0.492 mL | 0.984 mL | 1.23 mL |
| 100 mM | 0.0246 mL | 0.123 mL | 0.246 mL | 0.492 mL | 0.615 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Pyronaridine Tetraphosphate
Catalog No.:BCC1144
CAS No.:76748-86-2
- Decumbenine
Catalog No.:BCC8312
CAS No.:76733-83-0
- Mallorepine
Catalog No.:BCN4317
CAS No.:767-98-6
- 1-Deacetylnimbolinin B
Catalog No.:BCN4313
CAS No.:76689-98-0
- E-64-c
Catalog No.:BCC3588
CAS No.:76684-89-4
- RU 28318, potassium salt
Catalog No.:BCC7146
CAS No.:76676-34-1
- RU 26752
Catalog No.:BCC7531
CAS No.:76676-33-0
- Detomidine
Catalog No.:BCC4079
CAS No.:76631-46-4
- BAM 22P
Catalog No.:BCC5797
CAS No.:76622-26-9
- beta-D-Fructopyranose
Catalog No.:BCC8176
CAS No.:7660-25-5
- Imidazo[1,2-b]pyridazine
Catalog No.:BCC9001
CAS No.:766-55-2
- 3-Ethyl-4-methyl-3-pyrrolin-2-one
Catalog No.:BCC8632
CAS No.:766-36-9
- GBR 12935
Catalog No.:BCC5381
CAS No.:76778-22-8
- 2'-Hydroxydaidzein
Catalog No.:BCN4585
CAS No.:7678-85-5
- 3-Hydroxy-4',5,7-trimethoxyflavanone
Catalog No.:BCN4316
CAS No.:76792-94-4
- Azathramycin
Catalog No.:BCC1392
CAS No.:76801-85-9
- Potassium Iodide
Catalog No.:BCC4826
CAS No.:7681-11-0
- Ronidazole
Catalog No.:BCC4840
CAS No.:7681-76-7
- Pimaricin
Catalog No.:BCN2216
CAS No.:7681-93-8
- Danshensu
Catalog No.:BCN8513
CAS No.:76822-21-4
- Famotidine
Catalog No.:BCC4529
CAS No.:76824-35-6
- 5-BDBD
Catalog No.:BCC7717
CAS No.:768404-03-1
- Przewaquinone A
Catalog No.:BCN3004
CAS No.:76843-23-7
- 6-Hydroxywogonin
Catalog No.:BCN6556
CAS No.:76844-70-7
Lupalbigenin from Derris scandens Sensitizes Detachment-induced Cell Death in Human Lung Cancer Cells.[Pubmed:25964563]
Anticancer Res. 2015 May;35(5):2827-34.
BACKGROUND/AIM: The ability of cancer cells to resist to anoikis has been shown to augment cancer cell metastasis in many cancers. In search for potential substances for anti-metastatic approaches, this study aimed to investigate anoikis-sensitizing activity of Lupalbigenin, extracted from Derris scandens. MATERIALS AND METHODS: Human lung cancer cells were treated with non-cytotoxic concentrations of Lupalbigenin in a detachment condition. Anoikis was evaluated at various time points using MTT viability assays. The effect of Lupalbigenin on anchorage-independent growth was performed by soft-agar assay. The survival signaling proteins, as well as regulatory proteins of apoptosis and metastasis, were examined by western blot analysis. RESULTS: Lupalbigenin treatment significantly down-regulated survival proteins, including protein kinase B (pAKT/AKT) and extracellular signal-regulated kinase (pERK/ERK), as well as anti-apoptotic protein B-cell lymphoma 2 (BCL-2), resulting in the enhancement of the cellular response to anoikis and the decrease of growth and survival in an anchorage-independent condition. CONCLUSION: Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation.[Pubmed:27649772]
J Asian Nat Prod Res. 2017 May;19(5):510-518.
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), Lupalbigenin (5), laburnetin (6), isoLupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 muM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 +/- 2.4, 66.9 +/- 1.8, and 55.4 +/- 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC50 4.3 +/- 0.7 to 18.0 +/- 1.7 muM).
Bioassay-Guided Isolation of Two Flavonoids from Derris scandens with Topoisomerase II Poison Activity.[Pubmed:26754253]
Biol Pharm Bull. 2016;39(4):631-5.
Derris scandens (ROXB.) BENTH. (Fabaceae) is used as an alternative treatment for cancer in Thai traditional medicine. Investigation of the topoisomerase II (Top2) poison of compounds isolated from this plant may reveal new drug leads for the treatment of cancer. Bioassay-guided isolation was performed on an extract of D. scandens stems using a yeast cell-based assay. A yeast strain expressing the top2-1 temperature-sensitive mutant was used to assay Top2 activity. At the permissive temperature of 25 degrees C, yeast cells were highly sensitive to Top2 poison agents. At the semi-permissive temperature of 30 degrees C, where enzyme activity was present but greatly diminished, cells displayed only marginal sensitivity. The bioassay-guided fractionation of the extract led to the isolation of two known isoflavones: 5,7,4'-trihydroxy-6,8-diprenylisoflavone (1) and Lupalbigenin (2). These two compounds also displayed cytotoxicity against three different cancer cell lines, KB, MCF-7 and NCI-H187. In conclusion, Top2 poison agents from D. scandens are reported for the first time, substantiating the use of D. scandens in Thai traditional medicine for cancer treatment.
