LobetyolinCAS# 136085-37-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 136085-37-5 | SDF | Download SDF |
| PubChem ID | 53486204 | Appearance | Powder |
| Formula | C20H28O8 | M.Wt | 396.43 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Synonyms | 129277-38-9 | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R,4S,5S,6R)-2-[(4E,12E)-1,7-dihydroxytetradeca-4,12-dien-8,10-diyn-6-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | ||
| SMILES | CC=CC#CC#CC(C(C=CCCCO)OC1C(C(C(C(O1)CO)O)O)O)O | ||
| Standard InChIKey | MMMUDYVKKPDZHS-UPPVCQNNSA-N | ||
| Standard InChI | InChI=1S/C20H28O8/c1-2-3-4-5-7-10-14(23)15(11-8-6-9-12-21)27-20-19(26)18(25)17(24)16(13-22)28-20/h2-3,8,11,14-26H,6,9,12-13H2,1H3/b3-2+,11-8+/t14?,15?,16-,17-,18+,19-,20-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Lobetyolin has a protective role in gastric mucosa injury, and the mechanism may be relate to the increase in level of 6-K-PGF1αand the inhibition the excretion of gastric acid and EGF. Lobetyolin inhibits the gene expression of MUC5AC mucin induced by PMA. |
| Targets | EGFR |
| In vitro | Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells.[Pubmed: 25473407]Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8.In this study, we investigated whether Lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells.
|
| In vivo | Protective Effect of Lobetyolin on Gastric Mucosa of Experimental Gastric Ulcer in Rats[Reference: WebLink]Journal of Emergency in Traditional Chinese Medicine, 2008, 17(7):963-4.To study the protective effect of Lobetyolin on gastric mucosa of experimental gastric ulcer induced by ethanol in rats. |
| Structure Identification | Zhong Yao Cai. 2011 Apr;34(4):546-8.Studies on the chemical constituents of Codonopsis pilosula.[Pubmed: 21809539]To study the chemical constituents of Codonopsis pilosula.
|
Lobetyolin Dilution Calculator
Lobetyolin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5225 mL | 12.6126 mL | 25.2251 mL | 50.4503 mL | 63.0628 mL |
| 5 mM | 0.5045 mL | 2.5225 mL | 5.045 mL | 10.0901 mL | 12.6126 mL |
| 10 mM | 0.2523 mL | 1.2613 mL | 2.5225 mL | 5.045 mL | 6.3063 mL |
| 50 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.009 mL | 1.2613 mL |
| 100 mM | 0.0252 mL | 0.1261 mL | 0.2523 mL | 0.5045 mL | 0.6306 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Onjixanthone II
Catalog No.:BCN7559
CAS No.:136083-93-7
- 5-Methoxyisolariciresinol
Catalog No.:BCN7016
CAS No.:136082-41-2
- Necrosulfonamide
Catalog No.:BCC7992
CAS No.:1360614-48-7
- 9-Dehydroxyeurotinone
Catalog No.:BCN7397
CAS No.:1360606-85-4
- Desrhamnosylmartynoside
Catalog No.:BCN7648
CAS No.:136055-64-6
- [D-Lys3]-GHRP-6
Catalog No.:BCC5850
CAS No.:136054-22-3
- Justiciresinol
Catalog No.:BCN3419
CAS No.:136051-41-7
- Fmoc-Cys(pMeBzl)-OH
Catalog No.:BCC3476
CAS No.:136050-67-4
- Schisanlactone E
Catalog No.:BCN2593
CAS No.:136040-43-2
- Fmoc-Tic-OH
Catalog No.:BCC3341
CAS No.:136030-33-6
- (1R,2S)-1-Amino-2-indanol
Catalog No.:BCC8381
CAS No.:136030-00-7
- Angiotensin III (human, mouse)
Catalog No.:BCC1031
CAS No.:13602-53-4
- Isomucronulatol 7-O-beta-glucoside
Catalog No.:BCN8088
CAS No.:136087-29-1
- 14-Dehydrodelcosine
Catalog No.:BCN8119
CAS No.:1361-18-8
- LDC1267
Catalog No.:BCC5577
CAS No.:1361030-48-9
- Przewalskinic acid A
Catalog No.:BCN2925
CAS No.:136112-75-9
- 3,7-Di-O-methylducheside A
Catalog No.:BCN6191
CAS No.:136133-08-9
- Minocycline HCl
Catalog No.:BCC4679
CAS No.:13614-98-7
- (S)-(+)-Dimethindene maleate
Catalog No.:BCC7061
CAS No.:136152-65-3
- E3330
Catalog No.:BCC6421
CAS No.:136164-66-4
- INNO-206
Catalog No.:BCC1651
CAS No.:1361644-26-9
- Lobetyol
Catalog No.:BCN3321
CAS No.:136171-87-4
- 6-O-Caffeoylarbutin
Catalog No.:BCN6192
CAS No.:136172-60-6
- Sarranicine
Catalog No.:BCN2025
CAS No.:136173-25-6
Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells.[Pubmed:25473407]
Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8.
BACKGROUND: In this study, we investigated whether Lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells. METHODS: Confluent NCI-H292 cells were pretreated with Lobetyolin, lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin gene expression, and mucin protein production and secretion were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. RESULTS: Lobetyolin, lobetyol, and methyl linoleate inhibited the gene expression of MUC5AC mucin induced by PMA; Lobetyolin did not affect PMA-induced MUC5AC mucin production. However, lobetyol and methyl linoleate inhibited the production of MUC5AC mucin; Lobetyolin and lobetyol did not significantly affect PMA-induced MUC5AC mucin secretion from NCI-H292 cells. However, methyl linoleate decreased the MUC5AC mucin secretion. CONCLUSION: These results suggest that among the three compounds, methyl linoleate can regulate gene expression, production, and secretion of MUC5AC mucin by directly acting on the airway epithelial cells.
[Studies on the chemical constituents of Codonopsis pilosula].[Pubmed:21809539]
Zhong Yao Cai. 2011 Apr;34(4):546-8.
OBJECTIVE: To study the chemical constituents of Codonopsis pilosula. METHODS: The compounds were isolated and purified by column chromatography and their structures were elucidated through spectroscopic techniques (NMR) and physicochemical properties. RESULTS: The compounds were isolated as hesperidin(I), n-hexyl beta-sophoroside(II), atractylenolide III (III), Lobetyolin(IV), Lobetyolinin(V), taraxerol(VI), taraxeryl acetate(VII), alpha-spinasterol(VIII),9,10,13-trihydroxy-(E)-11-octadecenoic acid (IX),beta-sitosterol(X),beta-daucosterol(XI)and sugar(XII). CONCLUSION: Compounds 1 -2 and 9 are isolated from this plant for the first time.
