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Licoricesaponin G2

CAS# 118441-84-2

Licoricesaponin G2

Catalog No. BCN7897----Order now to get a substantial discount!

Product Name & Size Price Stock
Licoricesaponin G2:5mg Please Inquire In Stock
Licoricesaponin G2:10mg Please Inquire In Stock
Licoricesaponin G2:20mg Please Inquire In Stock
Licoricesaponin G2:50mg Please Inquire In Stock

Quality Control of Licoricesaponin G2

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Chemical structure

Licoricesaponin G2

3D structure

Chemical Properties of Licoricesaponin G2

Cas No. 118441-84-2 SDF Download SDF
PubChem ID 14891565 Appearance Powder
Formula C42H62O17 M.Wt 838.93
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3S,4S,5R,6R)-6-[(2R,3R,4S,5S,6S)-2-[[(3S,4S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4-(hydroxymethyl)-4,6a,6b,8a,11,14b-hexamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
SMILES CC12CCC(CC1C3=CC(=O)C4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)O)O)OC7C(C(C(C(O7)C(=O)O)O)O)O)C)(C)C(=O)O
Standard InChIKey WBQVRPYEEYUEBQ-OJVDLISWSA-N
Standard InChI InChI=1S/C42H62O17/c1-37-11-12-38(2,36(54)55)16-19(37)18-15-20(44)31-39(3)9-8-22(40(4,17-43)21(39)7-10-42(31,6)41(18,5)14-13-37)56-35-30(26(48)25(47)29(58-35)33(52)53)59-34-27(49)23(45)24(46)28(57-34)32(50)51/h15,19,21-31,34-35,43,45-49H,7-14,16-17H2,1-6H3,(H,50,51)(H,52,53)(H,54,55)/t19-,21+,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35+,37+,38-,39-,40+,41+,42+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Licoricesaponin G2

The roots of Glycyrrhiza uralensis

Biological Activity of Licoricesaponin G2

Description1. Licoricesaponin G2 has the anti-inflammatory effects as NF-κB inhibitors. 2. Licoricesaponin G2 has anti-HIV activity via significantly interacted with R15K.
TargetsHIV | NF-kB

Licoricesaponin G2 Dilution Calculator

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Licoricesaponin G2 Molarity Calculator

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Preparing Stock Solutions of Licoricesaponin G2

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.192 mL 5.96 mL 11.9199 mL 23.8399 mL 29.7999 mL
5 mM 0.2384 mL 1.192 mL 2.384 mL 4.768 mL 5.96 mL
10 mM 0.1192 mL 0.596 mL 1.192 mL 2.384 mL 2.98 mL
50 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.4768 mL 0.596 mL
100 mM 0.0119 mL 0.0596 mL 0.1192 mL 0.2384 mL 0.298 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Licoricesaponin G2

Rapid screening and identification of active ingredients in licorice extract interacting with V3 loop region of HIV-1 gp120 using ACE and CE-MS.[Pubmed:25854854]

J Pharm Biomed Anal. 2015;111:28-35.

The binding of envelope protein gp120 to glycosphingolipids is very important during the human immunodeficiency virus entering into the host cell. This step occurs in the V3 loop region in particularly. The conserved core sequence of V3 loop in gp120 was named R15K. Anti-HIV drug targeting to R15K would avoid the drug-resistance caused by HIV-1 genetic diversity. Here, for the first time, affinity capillary electrophoresis (ACE) and capillary electrophoresis-mass spectrometry (CE-MS) were used for establishing a simple, rapid and effective method of screening the licorice extract for biological activity (anti-HIV), which avoided the complicated isolation and purification process. R15K, 3'-sialyllactose (the positive control), and d-galactose (the negative control) were used for the development and validation of ACE method. After the interaction between licorice extract and R15K was confirmed by ACE, the relative active ingredients were isolated by SPE and their structures were determined by CE-ESI-MS online. In this research, two mixtures from licorice extract were found to be active. Furthermore, glycyrrhizin and licorice saponin G2 were verified as the main ingredients that significantly interacted with R15K via CE-MS and LC-MS. The results of quantitative assays showed that the active mixture contained glycyrrhizin of 74.23% and licorice saponin G2 of 9.52%. Calculated by Scatchard analysis method, glycyrrhizin/R15K complex had the highest binding constant (1.69 +/- 0.08) x 10(7)L/mol among 27 compounds isolated from licorice extract. The anti-HIV activity of glycyrrhizin was further confirmed by bioactive experiment of cellular level. This strategy might provide a high throughput screening and identifying platform for seeking HIV-1 inhibitors in natural products.

Description

Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera.

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