Laurycolactone ACAS# 85643-76-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 85643-76-1 | SDF | Download SDF |
| PubChem ID | 46878902 | Appearance | Cryst. |
| Formula | C18H22O5 | M.Wt | 318.4 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C2C(C3C4(C(CC(=O)C3(C1C(=O)O2)C)C(=CC4=O)C)C)O | ||
| Standard InChIKey | WDYBZQLVYRBSPT-ZICNYRAQSA-N | ||
| Standard InChI | InChI=1S/C18H22O5/c1-7-5-10(19)17(3)9(7)6-11(20)18(4)12-8(2)14(23-16(12)22)13(21)15(17)18/h5,8-9,12-15,21H,6H2,1-4H3/t8-,9+,12-,13+,14-,15-,17-,18+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Laurycolactone A is a natural product from Eurycoma longifolia Jack. |
| Structure Identification | Tetrahedron Letters, 1982 , 23 (49) :5159-5162.Structure of laurycolactone A and B, new C18 - quassinoids from Eurycoma longifolia and revised structured of Eurycomalactone (X - ray analysis) ☆[Reference: WebLink]
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Laurycolactone A Dilution Calculator
Laurycolactone A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1407 mL | 15.7035 mL | 31.407 mL | 62.8141 mL | 78.5176 mL |
| 5 mM | 0.6281 mL | 3.1407 mL | 6.2814 mL | 12.5628 mL | 15.7035 mL |
| 10 mM | 0.3141 mL | 1.5704 mL | 3.1407 mL | 6.2814 mL | 7.8518 mL |
| 50 mM | 0.0628 mL | 0.3141 mL | 0.6281 mL | 1.2563 mL | 1.5704 mL |
| 100 mM | 0.0314 mL | 0.157 mL | 0.3141 mL | 0.6281 mL | 0.7852 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Development of a selective HPLC-DAD/ELSD method for the qualitative and quantitative assessment of commercially available Eurycoma longifolia products and plant extracts.[Pubmed:29154863]
Fitoterapia. 2018 Jan;124:188-192.
Aqueous extracts of the roots of Eurycoma longifolia are traditionally used to improve sexual performance, to treat infertility and other sexual dysfunctions but also to increase muscle strength. Nowadays, many different products are commercially available which are promoted as E. longifolia extracts and claim to possess beneficial aphrodisiac effects. Since such herbal aphrodisiac preparations have been recently the target of fraudulent product counterfeiting and because eurycomanone, one of the main quassinoids of E. longifolia, is suspected to possess toxic effects at higher concentrations, a highly selective HPLC-DAD/ELSD method has been established to analyze commercially available products and extracts of plant material. The presented method was established by the use of a mixture of 27 reference compounds for qualitative issues and fully validated according to the ICH guidelines for the quantification of three quassinoides: Laurycolactone A, longilactone, and eurycomanone. The calibration curves of these showed a linearity over a range of 0.05 to 1.0mg/ml, with a regression coefficient not lower than R(2)=0.9969. The inter-day and intra-day precision (indicated as relative standard deviation) of the developed method was <2.9%. The recovery ranged from -3.3% to +6.0%. Eight randomly purchased products have been analyzed with this method, but only five of them contained E. longifolia compounds in detectable amounts. The concentration of eurycomanone in these products varied from 0.22+/-0.002mg eurycomanone per capsule to 1.84+/-0.08mg corresponding to a maximal recommended daily intake of 0.76+/-0.02 to 31.90+/-0.21mg.
