Ivabradine HClCAS# 148849-67-6 |
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| Cas No. | 148849-67-6 | SDF | Download SDF |
| PubChem ID | 3045381 | Appearance | Powder |
| Formula | C27H37ClN2O5 | M.Wt | 505.05 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | H2O : 50 mg/mL (99.00 mM; Need ultrasonic) DMSO : 25 mg/mL (49.50 mM; Need ultrasonic) | ||
| Chemical Name | 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride | ||
| SMILES | CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl | ||
| Standard InChIKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N | ||
| Standard InChI | InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells. |
Ivabradine HCl Dilution Calculator
Ivabradine HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.98 mL | 9.9 mL | 19.8 mL | 39.6 mL | 49.5 mL |
| 5 mM | 0.396 mL | 1.98 mL | 3.96 mL | 7.92 mL | 9.9 mL |
| 10 mM | 0.198 mL | 0.99 mL | 1.98 mL | 3.96 mL | 4.95 mL |
| 50 mM | 0.0396 mL | 0.198 mL | 0.396 mL | 0.792 mL | 0.99 mL |
| 100 mM | 0.0198 mL | 0.099 mL | 0.198 mL | 0.396 mL | 0.495 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Ivabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM, which is a pure heart rate lowering agent.
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DEVELOPMENT AND EVALUATION OF IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) AND ETHYL CELLULOSE FOR CONTROLLED DRUG RELEASE.[Pubmed:29624261]
Acta Pol Pharm. 2017 Mar;74(2):565-578.
The objective of this study was to prepare and evaluate Ivabradine HCl-loaded microspheres consisting of Eudragit LIOO-55 and ethyl cellulose prepared by oil-in-oil solvent evaporation method. Ivabradine HCl was encapsulated into microspheres by in situ method. The resultant microspheres were characterized with respect to drug loading, flow properties, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermal analysis and release behavior. Chemical stability of IBH after being encapsulated into microspheres was confirmed by FTR, DSC and XRD. FTIR spectra reflect- ed no interaction between drug and excipients. TGA indicates that prepared microspheres showed much better thermal stability than pure drug ivabradine. SEM images showed formulation of microspheres in spherical shape. The maximum perceniage entrapment efficiency was found to be 81 +/- 2.15 and percentage yield was 88 +/- 2.65. The maximum in vito drug release was 94.5% for the pH 7.4 and demonstrated that all drug-loaded formulations had a pH-dependent drug release. The cumulative drug release data were analyzed by applying different kinetic models. Korsmeyer-Peppas equation was used to determine value of n which follows non-Fickian diffusion.
Ivabradine hydrochloride is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
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