Itol ACAS# 1033747-78-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1033747-78-2 | SDF | Download SDF |
| PubChem ID | 24885741 | Appearance | Powder |
| Formula | C20H32O6 | M.Wt | 368.5 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,2S,3R,6R,7R,9S,10S,11S,12R,13R,14S)-3,7,10-trimethyl-11-propan-2-yl-15-oxapentacyclo[7.5.1.02,6.07,13.010,14]pentadecane-6,9,11,12,14-pentol | ||
| SMILES | CC1CCC2(C1C3C4(C5C2(CC(C4(C(C5O)(C(C)C)O)C)(O3)O)C)O)O | ||
| Standard InChIKey | HMPXQDVZEWENGB-FATXEXJGSA-N | ||
| Standard InChI | InChI=1S/C20H32O6/c1-9(2)19(24)13(21)12-15(4)8-18(23)16(19,5)20(12,25)14(26-18)11-10(3)6-7-17(11,15)22/h9-14,21-25H,6-8H2,1-5H3/t10-,11+,12+,13-,14-,15-,16+,17-,18+,19-,20-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Reference standards。 |
Itol A Dilution Calculator
Itol A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7137 mL | 13.5685 mL | 27.137 mL | 54.2741 mL | 67.8426 mL |
| 5 mM | 0.5427 mL | 2.7137 mL | 5.4274 mL | 10.8548 mL | 13.5685 mL |
| 10 mM | 0.2714 mL | 1.3569 mL | 2.7137 mL | 5.4274 mL | 6.7843 mL |
| 50 mM | 0.0543 mL | 0.2714 mL | 0.5427 mL | 1.0855 mL | 1.3569 mL |
| 100 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.5427 mL | 0.6784 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Toxicity and biochemical effects of itol A on the brown planthopper, Nilaparvata lugens (Stal) (Hemiptera: Delphacidae).[Pubmed:30497717]
Pestic Biochem Physiol. 2018 Nov;152:90-97.
Itol A, a novel isoryanodane diterpene derived from Itoa orientalis Hemsl., has potent activities against insect pests. This study was conducted to determine the contact toxicity and biochemical effects of Itol A on the Nilaparvata lugens. After macropterous females of N. lugens were exposed to Itol A from 0.5 to 24h, the mortality and poisoning symptoms were measured. Effects of Itol A on the major enzymes activity and oxidative stress level were assessed in dose-response (with LD10-LD70 at 24h) and time-course (with LD50 at 0.5-24h) experiments for the potential toxicity mechanisms. Based on the results, the mortality of N. lugens showed significant dose- and time-dependent effects, with the 24-h LD50 value was 0.58mug/insect. The symptoms of excitation, convulsion and paralysis were also observed. However, acetylcholinesterases (AChE) activity was not altered after Itol A treatment compared to control. Na(+)/K(+)-ATPases, Ca(2+)-ATPases, Ca(2+)/Mg(2+)-ATPases, glutathione S-transferases (GSTs), cytochrome P450 monooxygenases (P450s), superoxide dismutases (SOD) and catalases (CAT) activities were significantly reduced in dose-response and time-course experiments. While acid phosphatases (ACP) and glutathione peroxidases (GPX) activities were significantly increased. We further revealed that Itol A exposure resulted in the decrease of GSH/GSSG (reduced to oxidized glutathione) ratio and the increase of hydrogen peroxide (H2O2) and malondialdehyde (MDA) levels in both experiments. The results indicated that the inhibition of Na(+)/K(+)-ATPases, Ca(2+)-ATPases, Ca(2+)/Mg(2+)-ATPases, GSTs, P450s, SOD and CAT activities and the induction of oxidative stress was one of the potential biochemical mechanisms of Itol A against N. lugens.
