IBC 293Selective agonist for the GPR109B (HM74) receptor. Antilipolytic CAS# 306935-41-1 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 306935-41-1 | SDF | Download SDF |
| PubChem ID | 2736690 | Appearance | Powder |
| Formula | C10H11N3O2 | M.Wt | 205.22 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | ||
| Chemical Name | 1-propan-2-ylbenzotriazole-5-carboxylic acid | ||
| SMILES | CC(C)N1C2=C(C=C(C=C2)C(=O)O)N=N1 | ||
| Standard InChIKey | RUTVRAJKELSHCC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H11N3O2/c1-6(2)13-9-4-3-7(10(14)15)5-8(9)11-12-13/h3-6H,1-2H3,(H,14,15) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes. |
IBC 293 Dilution Calculator
IBC 293 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.8728 mL | 24.3641 mL | 48.7282 mL | 97.4564 mL | 121.8205 mL |
| 5 mM | 0.9746 mL | 4.8728 mL | 9.7456 mL | 19.4913 mL | 24.3641 mL |
| 10 mM | 0.4873 mL | 2.4364 mL | 4.8728 mL | 9.7456 mL | 12.182 mL |
| 50 mM | 0.0975 mL | 0.4873 mL | 0.9746 mL | 1.9491 mL | 2.4364 mL |
| 100 mM | 0.0487 mL | 0.2436 mL | 0.4873 mL | 0.9746 mL | 1.2182 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.[Pubmed:16480258]
J Med Chem. 2006 Feb 23;49(4):1227-30.
1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-raising drug niacin. No activity was observed at the highly homologous high-affinity niacin receptor GPR109a (HM74A). The high degree of selectivity was attributed to a difference in the amino acid sequence adjacent to a key arginine-ligand interaction allowing somewhat larger ligands to be tolerated by GPR109b.
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