Hosenkoside A

CAS# 156791-82-1

Hosenkoside A

Catalog No. BCN4962----Order now to get a substantial discount!

Product Name & Size Price Stock
Hosenkoside A:5mg Please Inquire In Stock
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Hosenkoside A:20mg Please Inquire In Stock
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Quality Control of Hosenkoside A

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Chemical structure

Hosenkoside A

3D structure

Chemical Properties of Hosenkoside A

Cas No. 156791-82-1 SDF Download SDF
PubChem ID 102004530 Appearance White powder
Formula C48H82O20 M.Wt 979.2
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in methanol; insoluble in water
Chemical Name (2R,3R,4S,5S,6R)-2-[[(1R,2S,2'S,4aR,4bR,6aS,7R,8S,10aR,10bR,12aR)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-7-hydroxy-2'-[(2S)-1-hydroxypropan-2-yl]-1,4a,10a,10b-tetramethylspiro[3,4,4b,5,6,6a,7,9,10,11,12,12a-dodecahydro-2H-chrysene-8,5'-oxane]-1-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES CC(CO)C1CCC2(CCC3(C(C2O)CCC4C3(CCC5C4(CCC(C5(C)COC6C(C(C(C(O6)CO)O)O)O)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)C)C)CO1
Standard InChIKey JUKFJOYCFLIWIA-MDQYKXRHSA-N
Standard InChI InChI=1S/C48H82O20/c1-22(16-49)24-8-13-48(21-62-24)15-14-46(4)23(40(48)61)6-7-29-44(2)11-10-30(45(3,28(44)9-12-47(29,46)5)20-63-41-37(59)34(56)31(53)25(17-50)64-41)67-43-39(36(58)33(55)27(19-52)66-43)68-42-38(60)35(57)32(54)26(18-51)65-42/h22-43,49-61H,6-21H2,1-5H3/t22-,23+,24-,25+,26+,27+,28+,29+,30-,31+,32+,33+,34-,35-,36-,37+,38+,39+,40+,41+,42-,43-,44-,45-,46+,47+,48+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Hosenkoside A

The aerial parts of Impatiens balsamina L.

Biological Activity of Hosenkoside A

DescriptionHosenkoside A is a nartural product from Impatiens balsamina L.

Protocol of Hosenkoside A

Structure Identification
Chinese Journal of Pharmaceutical Analysis, 2009(5): 717-20.

RP-HPLC determination of two hosenkosides in seeds of Impatiens balsamina L.[Reference: WebLink]

To determine two hosenkosides(hosenkoside K and Hosenkoside A)in the seeds of Impatiens balsamina.
METHODS AND RESULTS:
:Using RP-HPLC with ELSD method.Separation was carried out on Eclipse XDB-C18 column(4.6 mm×250 mm,5 μm).A linear solvent gradient was used,with a mobile phase of methanol-water(0-22 min,50∶50;22-50 min,54∶46).The flow rate was 0.8 mL·min-1 at 25 ℃.The gas(air)flow rate was 2.5 L·min-1 and the temperature of drift tube for measurement was 89 ℃.The linearity was in the range of 5-20 μg for hosenkoside K and A,and the correlation coefficients(n=6)were 0.9995 and 0.9992 respectively;The average recoveries(n=6)for hosenkoside K and A were 98.0%(RSD=1.3%)and 98.0%(RSD=1.3%)respectively.
CONCLUSIONS:
This method is accurate,reliable and reproducible for determination of hosenkoside K and A in the seeds of Impatiens balsamina.

Hosenkoside A Dilution Calculator

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Hosenkoside A Molarity Calculator

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Preparing Stock Solutions of Hosenkoside A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.0212 mL 5.1062 mL 10.2124 mL 20.4248 mL 25.531 mL
5 mM 0.2042 mL 1.0212 mL 2.0425 mL 4.085 mL 5.1062 mL
10 mM 0.1021 mL 0.5106 mL 1.0212 mL 2.0425 mL 2.5531 mL
50 mM 0.0204 mL 0.1021 mL 0.2042 mL 0.4085 mL 0.5106 mL
100 mM 0.0102 mL 0.0511 mL 0.1021 mL 0.2042 mL 0.2553 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Hosenkoside A

An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study.[Pubmed:27518831]

Biomed Chromatogr. 2017 Mar;31(3).

A rapid and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of two baccharane glycosides (Hosenkoside A and hosenkoside K) of total saponins of Semen Impatientis in rat plasma using mogroside V as the internal standard (IS). The analytes were separated using a C18 RP Agilent XDB column (1.8 mum, 50 x 2.1 mm i.d.) and detection of the compounds was done using a TSQ Quantum triple quadrupole mass spectrometer coupled with a negative electrospray ionization source under selection reaction monitoring mode. According to the US Food and Drug Administration guidelines, the established method was fully validated and the results were proved within acceptable limits. The lower limits of quantification of both analytes were 5 ng/mL. The validated method was successfully applied to a pharmacokinetic study of orally administered the total saponins of Semen Impatientis in rats.

Description

Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina.

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