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Guan-fu base A

CAS# 1394-48-5

Guan-fu base A

Catalog No. BCN8491----Order now to get a substantial discount!

Product Name & Size Price Stock
Guan-fu base A: 5mg Please Inquire In Stock
Guan-fu base A: 10mg Please Inquire In Stock
Guan-fu base A: 20mg Please Inquire Please Inquire
Guan-fu base A: 50mg Please Inquire Please Inquire
Guan-fu base A: 100mg Please Inquire Please Inquire
Guan-fu base A: 200mg Please Inquire Please Inquire
Guan-fu base A: 500mg Please Inquire Please Inquire
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Quality Control of Guan-fu base A

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Chemical structure

Guan-fu base A

3D structure

Chemical Properties of Guan-fu base A

Cas No. 1394-48-5 SDF Download SDF
PubChem ID 101603171 Appearance Powder
Formula C24H31NO6 M.Wt 429.51
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(=O)OC1CC2(CN3C4C2C5(C1)C3C6(C(C7C(C5C6(C4)CC7=C)O)OC(=O)C)O)C
Standard InChIKey OGNUSOJAYIHLNS-CGMBEVFJSA-N
Standard InChI InChI=1S/C24H31NO6/c1-10-5-22-8-14-17-21(4)6-13(30-11(2)26)7-23(17)18(22)16(28)15(10)19(31-12(3)27)24(22,29)20(23)25(14)9-21/h13-20,28-29H,1,5-9H2,2-4H3/t13-,14-,15+,16+,17+,18+,19?,20-,21+,22+,23-,24-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Guan-fu base A Dilution Calculator

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Guan-fu base A Molarity Calculator

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Preparing Stock Solutions of Guan-fu base A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3282 mL 11.6412 mL 23.2823 mL 46.5647 mL 58.2059 mL
5 mM 0.4656 mL 2.3282 mL 4.6565 mL 9.3129 mL 11.6412 mL
10 mM 0.2328 mL 1.1641 mL 2.3282 mL 4.6565 mL 5.8206 mL
50 mM 0.0466 mL 0.2328 mL 0.4656 mL 0.9313 mL 1.1641 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.4656 mL 0.5821 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes. Guanfu base A also inhibits HERG channel current.

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