DeacetyltanghininCAS# 4589-95-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 4589-95-1 | SDF | Download SDF |
| PubChem ID | 21637810 | Appearance | Powder |
| Formula | C30H44O9 | M.Wt | 548.7 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-[(1R,3S,5S,7S,10S,11R,14R,15R,18R)-7-[(2R,3S,4R,5S,6S)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-18-hydroxy-10,14-dimethyl-2-oxapentacyclo[9.7.0.01,3.05,10.014,18]octadecan-15-yl]-2H-furan-5-one | ||
| SMILES | CC1C(C(C(C(O1)OC2CCC3(C4CCC5(C(CCC5(C46C(O6)CC3C2)O)C7=CC(=O)OC7)C)C)O)OC)O | ||
| Standard InChIKey | LVGNJQMAMYJAIL-FWMNQDIBSA-N | ||
| Standard InChI | InChI=1S/C30H44O9/c1-15-23(32)25(35-4)24(33)26(37-15)38-18-5-8-27(2)17(12-18)13-21-30(39-21)20(27)7-9-28(3)19(6-10-29(28,30)34)16-11-22(31)36-14-16/h11,15,17-21,23-26,32-34H,5-10,12-14H2,1-4H3/t15-,17-,18-,19+,20+,21-,23-,24-,25+,26-,27-,28+,29+,30+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Deacetyltanghinin Dilution Calculator
Deacetyltanghinin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8225 mL | 9.1124 mL | 18.2249 mL | 36.4498 mL | 45.5622 mL |
| 5 mM | 0.3645 mL | 1.8225 mL | 3.645 mL | 7.29 mL | 9.1124 mL |
| 10 mM | 0.1822 mL | 0.9112 mL | 1.8225 mL | 3.645 mL | 4.5562 mL |
| 50 mM | 0.0364 mL | 0.1822 mL | 0.3645 mL | 0.729 mL | 0.9112 mL |
| 100 mM | 0.0182 mL | 0.0911 mL | 0.1822 mL | 0.3645 mL | 0.4556 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The principal toxic glycosidic steroids in Cerbera manghas L. seeds: identification of cerberin, neriifolin, tanghinin and deacetyltanghinin by UHPLC-HRMS/MS, quantification by UHPLC-PDA-MS.[Pubmed:24878878]
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jul 1;962:1-8.
The toxicity of the sea mango (Cerbera manghas L.) is well known. The plant is ranked as one of the deadliest of the southern Asian coastline. Cardenolidic heterosides are responsible for the cardiotoxicity of trees of the Cerbera genus. We have identified and determined the concentration of the principal glycosidic steroids present in the seeds of sea mangos (Thailand). Drug screening of an extract of the seeds was carried out using ultra-high performance liquid chromatography coupled to photodiode array detection and mass spectrometry (UHPLC-PDA-MS) with quantification at 219nm. Identification was confirmed by UHPLC-HRMS. Deacetyltanghinin (m/z 549.3055+/-2ppm), neriifolin (m/z 535.3259+/-2ppm), tanghinin (m/z 591.3169+/-2ppm) and cerberin (577.3375+/-2ppm) were the most abundant glycosidic steroids present in the sea mango seeds. A seed of the dried ripe fruit had concentrations of 1209.1, 804.2, 621.4 and 285.9mug/g, respectively. A seed of the fresh unripe fruit had concentrations of 49.4, 47.0, 3.5 and 2.3mug/g.
New cytotoxic cardenolide glycoside from the seeds of Cerbera manghas.[Pubmed:15305009]
Chem Pharm Bull (Tokyo). 2004 Aug;52(8):1023-5.
A new cytotoxic cardenolide glycoside, 3beta-O-(2'-O-acetyl-alpha-L-thevetosyl)-14beta-hydroxy-7-en-5beta-card-20(22)-enolide, (7,8-dehydrocerberin), together with five known cardenolides, 17beta-neriifolin, Deacetyltanghinin, tanghinin, cerberin and 2'-O-acetyl-cerleaside A were isolated from the seeds of Cerbera manghas L. Their structures were elucidated by 1D- and 2D-NMR techniques as well as UV, IR and mass spectral data. 7,8-Dehydrocerberin, Deacetyltanghinin and tanghinin exhibited cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cells lung cancer (NCI-H187).
