Conduritol ACAS# 526-87-4 |
- (-)-Conduritol F
Catalog No.:BCN0266
CAS No.:6090-98-8
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 526-87-4 | SDF | Download SDF |
| PubChem ID | 136345 | Appearance | Cryst. |
| Formula | C6H10O4 | M.Wt | 146.1 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | cyclohex-5-ene-1,2,3,4-tetrol | ||
| SMILES | C1=CC(C(C(C1O)O)O)O | ||
| Standard InChIKey | LRUBQXAKGXQBHA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C6H10O4/c7-3-1-2-4(8)6(10)5(3)9/h1-10H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting cataracts through the inhibition of lens aldose reductase. |
| Targets | TNF-α | Lens aldose reductase |
| In vivo | Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre[Pubmed: 19294862]Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5.To investigates the mechanism of hypooglycemic effect of Conduritol A of stems of Gymnema sylvestre.
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| Animal Research | Effect of Conduritol A, a Polyol from Gymnema sylvestre, on the Development of Diabetic Cataracts in Streptozotocin-treated Rats and on Aldose Reductase.[Reference: WebLink]Biosci.Biotech. Biochem.,1994, 58(4):756-7.
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Conduritol A Dilution Calculator
Conduritol A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.8446 mL | 34.2231 mL | 68.4463 mL | 136.8925 mL | 171.1157 mL |
| 5 mM | 1.3689 mL | 6.8446 mL | 13.6893 mL | 27.3785 mL | 34.2231 mL |
| 10 mM | 0.6845 mL | 3.4223 mL | 6.8446 mL | 13.6893 mL | 17.1116 mL |
| 50 mM | 0.1369 mL | 0.6845 mL | 1.3689 mL | 2.7379 mL | 3.4223 mL |
| 100 mM | 0.0684 mL | 0.3422 mL | 0.6845 mL | 1.3689 mL | 1.7112 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre].[Pubmed:19294862]
Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5.
OBJECTIVE: To investigates the mechanism of hypooglycemic effect of Conduritol A of stems of Gymnema sylvestre. METHOD: Fourteen days later after administration, observation is taken on the change of these mice and rats weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also detected with enzymology method and Radioimmuoassay method. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet beta-cell. Calulate thymus, pancreas, splenica index. RESULT: Compared with diabetic model mice, high and middosage of Conduritol A could remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P < 0.01). Significantly increase the level of serum insulin (P < 0.05). Activity of SOD was obviously increased, and amount of MDA was obviously decreased (P < 0.05). The amount of Conduritol A disposal of glucose was obviously increased (P < 0.05). Significantly increase thymus, pancreas, splencia index (P < 0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell structure and form of Conduritol A had been some way improved. The immunohistochemistry results showed that beta-cells numbers of pancreas in each Conduritol A group were more than those in the model group. CONCLUSION: Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger.
