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Brevifolincarboxylic acid

CAS# 18490-95-4

Brevifolincarboxylic acid

Catalog No. BCN3884----Order now to get a substantial discount!

Product Name & Size Price Stock
Brevifolincarboxylic acid:5mg Please Inquire In Stock
Brevifolincarboxylic acid:10mg Please Inquire In Stock
Brevifolincarboxylic acid:20mg Please Inquire In Stock
Brevifolincarboxylic acid:50mg Please Inquire In Stock

Quality Control of Brevifolincarboxylic acid

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Chemical structure

Brevifolincarboxylic acid

3D structure

Chemical Properties of Brevifolincarboxylic acid

Cas No. 18490-95-4 SDF Download SDF
PubChem ID 9838995 Appearance Yellowish powder
Formula C13H8O8 M.Wt 292.2
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in DMSO and water
Chemical Name 7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylic acid
SMILES C1C(C2=C(C1=O)OC(=O)C3=CC(=C(C(=C32)O)O)O)C(=O)O
Standard InChIKey JFJWMFPFMLRLMI-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H8O8/c14-5-2-4-7(10(17)9(5)16)8-3(12(18)19)1-6(15)11(8)21-13(4)20/h2-3,14,16-17H,1H2,(H,18,19)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Brevifolincarboxylic acid

1 Punica sp.

Biological Activity of Brevifolincarboxylic acid

Description1. Brevifolincarboxylic acid shows marked inhibitory effects on aryl hydrocarbon receptor -based bioassay activation by TCDD, and its effect is dose dependent. 2. Brevifolincarboxylic acid (IC50 = 18.0 uM) shows good antioxidant activity. 3. Brevifolincarboxylic acid shows moderate antibacterial activity against Salmonella enteritidis , Salmonella typhimurium , and Salmonella abony.
TargetsAntifection

Brevifolincarboxylic acid Dilution Calculator

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Brevifolincarboxylic acid Molarity Calculator

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Preparing Stock Solutions of Brevifolincarboxylic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4223 mL 17.1116 mL 34.2231 mL 68.4463 mL 85.5578 mL
5 mM 0.6845 mL 3.4223 mL 6.8446 mL 13.6893 mL 17.1116 mL
10 mM 0.3422 mL 1.7112 mL 3.4223 mL 6.8446 mL 8.5558 mL
50 mM 0.0684 mL 0.3422 mL 0.6845 mL 1.3689 mL 1.7112 mL
100 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.6845 mL 0.8556 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Brevifolincarboxylic acid

Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.[Pubmed:14646185]

Biol Pharm Bull. 2003 Dec;26(12):1754-60.

The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to environmental contaminants such as dioxins, which have many adverse health effects. We performed a preliminary screening of the inhibitory effects of vegetable constituents on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of AhR using the AhR-based bioassay for dioxins, the Ah-Immunoassay. Ninety vegetable constituents including flavonoids, tannins, saponins, terpenes, etc., were assayed in vitro. Among them, flavones, flavonols, anthraquinones, piperine, coumestrol, Brevifolincarboxylic acid, and resveratrol showed marked inhibitory effects on AhR-based bioassay activation by TCDD, and their effects were dose dependent. Curcumin, carnosol, and capsaicin also inhibited the activation of AhR in this assay, although to a lesser degree. These results suggest that several vegetable constituents might play a role in protection against dioxin toxicity.

Description

Brevifolincarboxylic acid is extracted from Polygonum capitatum, has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM.

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