2'-O-MethylisoliquiritigeninCAS# 51828-10-5 |
- 3-Deoxysappanchalcone
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 51828-10-5 | SDF | Download SDF |
| PubChem ID | 25201046 | Appearance | Orange powder |
| Formula | C16H14O4 | M.Wt | 270.3 |
| Type of Compound | Chalcones | Storage | Desiccate at -20°C |
| Synonyms | Isoliquiritigenin 2'-methyl ether | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one | ||
| SMILES | COC1=C(C=CC(=C1)O)C(=O)C=CC2=CC=C(C=C2)O | ||
| Standard InChIKey | PACBGANPVNHGNP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H14O4/c1-20-16-10-13(18)7-8-14(16)15(19)9-4-11-2-5-12(17)6-3-11/h2-10,17-18H,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
2'-O-Methylisoliquiritigenin Dilution Calculator
2'-O-Methylisoliquiritigenin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6996 mL | 18.498 mL | 36.9959 mL | 73.9919 mL | 92.4898 mL |
| 5 mM | 0.7399 mL | 3.6996 mL | 7.3992 mL | 14.7984 mL | 18.498 mL |
| 10 mM | 0.37 mL | 1.8498 mL | 3.6996 mL | 7.3992 mL | 9.249 mL |
| 50 mM | 0.074 mL | 0.37 mL | 0.7399 mL | 1.4798 mL | 1.8498 mL |
| 100 mM | 0.037 mL | 0.185 mL | 0.37 mL | 0.7399 mL | 0.9249 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Sedative-hypnotic and anxiolytic effects and the mechanism of action of aqueous extracts of peanut stems and leaves in mice.[Pubmed:29572847]
J Sci Food Agric. 2018 Oct;98(13):4885-4894.
INTRODUCTION: Peanut stems and leaves (PSL) have traditionally been used as both a special food and a herbal medicine in Asia. The sedative-hypnotic and anxiolytic effects of PSL have been recorded in classical traditional Chinese literature, and more recently by many other researchers. In a previous study, four sleep-related ingredients (linalool, 5-hydroxy-4',7-dimethoxyflavanone, 2'-O-methylisoliquiritigenin and ferulic acid), among which 5-hydroxy-4',7-dimethoxyflavanone and 2'-O-methylisoliquiritigenin were newly found in Arachis species, were screened by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS). In the current study, quantitative examination of the above four ingredients was conducted. Serious fundamental functional studies were done in mice, including locomotor activity, direct sleep tests, pentobarbital-induced sleeping time tests, subthreshold dose of pentobarbital tests and barbital sodium sleep incubation period tests, to determine the material base for the sedative-hypnotic and anxiolytic effects of aqueous extracts of PSL. Furthermore, neurotransmitter levels in three brain regions (cerebrum, cerebellum and brain stem) were determined using UHPLC coupled with triple-quadrupole mass spectrometry (UHPLC/QQQ-MS) in order to elucidate the exact mechanism of action. RESULTS: Aqueous extract of PSL at a dose of 500 mg kg(-1) (based on previous experience), along with different concentrations of the above four functional ingredients (189.86 microg kg(-1) linalool, 114.75 mg kg(-1) 5-hydroxy-4',7-dimethoxyflavanone, 32.4mg kg(-1) 2'-O-methylisoliquiritigenin and 44.44 mg kg(-1) ferulic acid), had a sedative-hypnotic effect by affecting neurotransmitter levels in mice. CONCLUSION: The data demonstrate that these four ingredients are the key functional factors for the sedative-hypnotic and anxiolytic effects of PSL aqueous extracts and that these effects occur via changes in neurotransmitter levels and pathways. (c) 2018 Society of Chemical Industry.
