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2-Amino-6-nitrobenzothiazole

CAS# 6285-57-0

2-Amino-6-nitrobenzothiazole

Catalog No. BCC8544----Order now to get a substantial discount!

Product Name & Size Price Stock
2-Amino-6-nitrobenzothiazole: 5mg $17 In Stock
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Chemical structure

2-Amino-6-nitrobenzothiazole

3D structure

Chemical Properties of 2-Amino-6-nitrobenzothiazole

Cas No. 6285-57-0 SDF Download SDF
PubChem ID 22704 Appearance Powder
Formula C7H5N3O2S M.Wt 195
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 6-nitro-1,3-benzothiazol-2-amine
SMILES C1=CC2=C(C=C1[N+](=O)[O-])SC(=N2)N
Standard InChIKey GPNAVOJCQIEKQF-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H5N3O2S/c8-7-9-5-2-1-4(10(11)12)3-6(5)13-7/h1-3H,(H2,8,9)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

2-Amino-6-nitrobenzothiazole Dilution Calculator

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2-Amino-6-nitrobenzothiazole Molarity Calculator

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Preparing Stock Solutions of 2-Amino-6-nitrobenzothiazole

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.1282 mL 25.641 mL 51.2821 mL 102.5641 mL 128.2051 mL
5 mM 1.0256 mL 5.1282 mL 10.2564 mL 20.5128 mL 25.641 mL
10 mM 0.5128 mL 2.5641 mL 5.1282 mL 10.2564 mL 12.8205 mL
50 mM 0.1026 mL 0.5128 mL 1.0256 mL 2.0513 mL 2.5641 mL
100 mM 0.0513 mL 0.2564 mL 0.5128 mL 1.0256 mL 1.2821 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2-Amino-6-nitrobenzothiazole

Anticonvulsant activity, organotypic hippocampal neuroprotection assay and in-silico sodium channel blocking potential of 2-amino-6-nitrobenzothiazole derived semicarbazones.[Pubmed:28946193]

Biomed Pharmacother. 2017 Nov;95:1451-1460.

Epilepsy is one of the dreadful neurodegenerative disorder characterized by recurrent, unprovoked seizures. Currently available antiepileptic drugs are still associated with enormous side effects resulting in search of newer, more effective and safer agents. In view of this, we have investigated anticonvulsant activity of 2-Amino-6-nitrobenzothiazole derived semicarbazones (7-32) in various in-vivo animal seizure models viz. maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and 6Hz psychomotor seizure model. Neurotoxicity was estimated by rotarod test. The compounds were also assessed for their neuroprotective potential from excitotoxic insult using organotypic hippocampal slice culture neuroprotection assay. Several compounds exhibited excellent anticonvulsant activity in MES and scPTZ models compared to reference drugs, phenytoin and levetiracetam. The results of kainic acid (KA) - induced neuroprotection assay indicated that compounds 26 and 24 were found to be most potent with IC50 of 99.54+/-1.27 and 101.00+/-1.20muM respectively. Both the compounds attenuated KA-mediated cell death in organotypic hippocampal slice cultures. Some of the compounds were found to be good antidepressants, better than the reference drug citalopram, when analyzed in forced swim test. Since semicarbazones exhibited profile resembling phenytoin, an attempt was made to screen them against human neuronal sodium channel isoform (hNav1.2) by performing computational molecular docking using AutoDock 4.2. Compound 30, 1-(5-Chloro-2-oxoindolin-3-ylidene)-4-(6-nitrobenzothiazol-2-yl)semicarbazide emerged as lead candidate possessing excellent in-vivo MES activity and high binding affinity computationally, better than the reference drug phenytoin and also exhibited neuroprotection from excitotoxic insult in KA-induced neuroprotection assay (IC50=126.80+/-1.24muM). However, some of the active compounds were neurotoxic at their anticonvulsant doses. Further optimization studies are needed to reduce toxicity and develop them as novel therapeutic agents for epilepsy.

Bismuth film electrode at a silver solid amalgam substrate as a new tool for voltammetric determination of electrochemically reducible organic compounds.[Pubmed:23182576]

Talanta. 2012 Dec 15;102:68-74.

New type of bismuth film electrode prepared by electrodeposition of bismuth film on a silver solid amalgam substrate (BiF-AgSAE) was tested as a sensor for voltammetric determination of electrochemically reducible organic substances using 2-Amino-6-nitrobenzothiazole (ANBT) as a model analyte. Using the optimized conditions (a 9:1 (v/v) mixture of aqueous Britton-Robinson buffer solution (pH 10.0) and methanol), the limits of quantification are 0.16 mumol L(-1) for direct current voltammetry (DCV) and 0.22 mumol L(-1) for differential pulse voltammetry (DPV). The obtained calibration dependences are linear in the concentration range from 0.2 to 100 mumol L(-1) and the practical applicability of the newly developed electrode for the direct determination of ANBT in tap and mineral water model samples was confirmed in the concentration range from 0.2 to 10 mumol L(-1).

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