2-(3,4-Dihydroxyphenyl)ethanolCAS# 10597-60-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 10597-60-1 | SDF | Download SDF |
| PubChem ID | 82755 | Appearance | Colorless liquid |
| Formula | C8H10O3 | M.Wt | 154.2 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Synonyms | 3,4-Dihydroxyphenethyl alcohol; Homoprotocatechuyl alcohol | ||
| Solubility | Soluble in methan | ||
| Chemical Name | 4-(2-hydroxyethyl)benzene-1,2-diol | ||
| SMILES | C1=CC(=C(C=C1CCO)O)O | ||
| Standard InChIKey | JUUBCHWRXWPFFH-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 2-(3,4-Dihydroxyphenyl)ethanol has antioxidant properties; it is a potent specific inhibitor of lipoxygenase activities, it inhibits platelet 12-LO activity (IC50, 4.2 microM) and PMNL 5-LO activity (IC50, 13 microM) but not cyclooxygenase activity in cell-free conditions; it also inhibits 12-LO activity in intact platelets (IC50, 50 microM) and reduces leukotriene B4 production in intact PMNL stimulated by A23187 (IC50, 26 microM). |
| Targets | Immunology & Inflammation related | SOD | CAT |
| In vivo | Antioxidant role of hydroxytyrosol on oxidative stress in cadmium-intoxicated rats: different effect in spleen and testes.[Pubmed: 24437686 ]Drug Chem Toxicol. 2014 Oct;37(4):420-6.Hydroxytyrosol (2-(3,4-Dihydroxyphenyl)ethanol, (DPE), a phenolic compound present in olive oil, is known to have antioxidant properties. |
| Kinase Assay | Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives.[Pubmed: 9058975]Biosci Biotechnol Biochem. 1997 Feb;61(2):347-50.
|
2-(3,4-Dihydroxyphenyl)ethanol Dilution Calculator
2-(3,4-Dihydroxyphenyl)ethanol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.4851 mL | 32.4254 mL | 64.8508 mL | 129.7017 mL | 162.1271 mL |
| 5 mM | 1.297 mL | 6.4851 mL | 12.9702 mL | 25.9403 mL | 32.4254 mL |
| 10 mM | 0.6485 mL | 3.2425 mL | 6.4851 mL | 12.9702 mL | 16.2127 mL |
| 50 mM | 0.1297 mL | 0.6485 mL | 1.297 mL | 2.594 mL | 3.2425 mL |
| 100 mM | 0.0649 mL | 0.3243 mL | 0.6485 mL | 1.297 mL | 1.6213 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Sulfocostunolide B
Catalog No.:BCN5870
CAS No.:1059671-65-6
- Clinafloxacin CI96 AM1091
Catalog No.:BCC3754
CAS No.:105956-97-6
- OLDA
Catalog No.:BCC7138
CAS No.:105955-11-1
- STEARDA
Catalog No.:BCC7288
CAS No.:105955-10-0
- Doxycycline HCl
Catalog No.:BCC3772
CAS No.:10592-13-9
- Taraxasterol
Catalog No.:BCN5869
CAS No.:1059-14-9
- (tert-Butoxycarbonyl)oxycefcapene pivoxil
Catalog No.:BCC8403
CAS No.:105889-80-3
- Obtusilin
Catalog No.:BCN2697
CAS No.:105870-59-5
- TSTU
Catalog No.:BCC2828
CAS No.:105832-38-0
- Tropisetron Hydrochloride
Catalog No.:BCC4027
CAS No.:105826-92-4
- Nateglinide
Catalog No.:BCC5005
CAS No.:105816-04-4
- E-3810
Catalog No.:BCC1541
CAS No.:1058137-23-7
- Geraniol
Catalog No.:BCN2631
CAS No.:106-24-1
- Nerol
Catalog No.:BCN8517
CAS No.:106-25-2
- β-Interleukin I (163-171), human
Catalog No.:BCC1017
CAS No.:106021-96-9
- Palmatine hydrochloride
Catalog No.:BCN5914
CAS No.:10605-02-4
- Hoechst 33342 analog 2
Catalog No.:BCC1631
CAS No.:106050-84-4
- Senktide
Catalog No.:BCC6921
CAS No.:106128-89-6
- PND-1186
Catalog No.:BCC1866
CAS No.:1061353-68-1
- TC-G 1004
Catalog No.:BCC6165
CAS No.:1061747-72-5
- WAY-600
Catalog No.:BCC4607
CAS No.:1062159-35-6
- WYE-687
Catalog No.:BCC4604
CAS No.:1062161-90-3
- WYE-354
Catalog No.:BCC1059
CAS No.:1062169-56-5
- Ro3280
Catalog No.:BCC3962
CAS No.:1062243-51-9
Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives.[Pubmed:9058975]
Biosci Biotechnol Biochem. 1997 Feb;61(2):347-50.
The effects of olive fruit extract on arachidonic acid lipoxygenase activities were investigated using rat platelets and rat polymorphonuclear leukocytes (PMNL). Olive extract strongly inhibited both 12-lipoxygenase (12-LO) and 5-lipoxygenase (5-LO) activities. One of the compounds responsible for this inhibition was purified and identified as 2-(3,4-Dihydroxyphenyl)ethanol (DPE). DPE inhibited platelet 12-LO activity (IC50, 4.2 microM) and PMNL 5-LO activity (IC50, 13 microM) but not cyclooxygenase activity in cell-free conditions. It also inhibited 12-LO activity in intact platelets (IC50, 50 microM) and reduced leukotriene B4 production in intact PMNL stimulated by A23187 (IC50, 26 microM). The inhibition by DPE of both lipoxygenase activities was stronger than that by oleuropein, caffeic acid, or 7 other related phenolic compounds, especially in intact cells. These results suggest that DPE is a potent specific inhibitor of lipoxygenase activities.
