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11,12-De(methylenedioxy)danuphylline

CAS# 888482-17-5

11,12-De(methylenedioxy)danuphylline

Catalog No. BCN4436----Order now to get a substantial discount!

Product Name & Size Price Stock
11,12-De(methylenedioxy)danuphylline:5mg Please Inquire In Stock
11,12-De(methylenedioxy)danuphylline:10mg Please Inquire In Stock
11,12-De(methylenedioxy)danuphylline:20mg Please Inquire In Stock
11,12-De(methylenedioxy)danuphylline:50mg Please Inquire In Stock

Quality Control of 11,12-De(methylenedioxy)danuphylline

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Chemical structure

11,12-De(methylenedioxy)danuphylline

3D structure

Chemical Properties of 11,12-De(methylenedioxy)danuphylline

Cas No. 888482-17-5 SDF Download SDF
PubChem ID 91885229 Appearance Cryst.
Formula C23H26N2O6 M.Wt 426.5
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES COC(=O)C12CCC34CCCN(C3C1(CC(=O)C4)C5=CC=CC=C5N2C(=O)OC)C=O
Standard InChIKey OMANQXKGUWJXTD-JBJBFBLISA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 11,12-De(methylenedioxy)danuphylline

The branch of Kopsia officinalis

Biological Activity of 11,12-De(methylenedioxy)danuphylline

DescriptionStandard reference
In vitro

Three New Indole Alkaloids from the Leaves of Kopsia officinalis.[Reference: WebLink]

Helvetica Chimica Acta.2006 March;89(3):515–519.


METHODS AND RESULTS:
Three new indole alkaloids, 11,12-De(methylenedioxy)danuphylline (1), methyl (2β,11β,12β,19α)-6,7-didehydro-8,21-dioxo-11,21-cycloaspidospermidine-2-carboxylate (2), and (2β,5β)-aspidofractinin-16-ol (3) were isolated from Kopsia officinalis, together with 16 known compounds. Their structures were determined by spectroscopic methods.
CONCLUSIONS:
The isolated known compound (−)-12-methoxykopsinaline displayed antimanic effects in Drosophila, with an IC50 value of 12.5 μg/ml.

11,12-De(methylenedioxy)danuphylline Dilution Calculator

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11,12-De(methylenedioxy)danuphylline Molarity Calculator

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Preparing Stock Solutions of 11,12-De(methylenedioxy)danuphylline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3447 mL 11.7233 mL 23.4467 mL 46.8933 mL 58.6166 mL
5 mM 0.4689 mL 2.3447 mL 4.6893 mL 9.3787 mL 11.7233 mL
10 mM 0.2345 mL 1.1723 mL 2.3447 mL 4.6893 mL 5.8617 mL
50 mM 0.0469 mL 0.2345 mL 0.4689 mL 0.9379 mL 1.1723 mL
100 mM 0.0234 mL 0.1172 mL 0.2345 mL 0.4689 mL 0.5862 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 11,12-De(methylenedioxy)danuphylline

Three New Indole Alkaloids from the Leaves of Kopsia officinalis.

Helvetica Chimica Acta.2006 March;89(3):515–519.

Three new indole alkaloids, 11,12-De(methylenedioxy)danuphylline (1), methyl (2β,11β,12β,19α)-6,7-didehydro-8,21-dioxo-11,21-cycloaspidospermidine-2-carboxylate (2), and (2β,5β)-aspidofractinin-16-ol (3) were isolated from Kopsia officinalis, together with 16 known compounds. Their structures were determined by spectroscopic methods. The isolated known compound (−)-12-methoxykopsinaline displayed antimanic effects in Drosophila, with an IC50 value of 12.5 μg/ml.

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