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Pain and Inflammation Research

Although separate conditions, pain and inflammation are nearly always associated with each other. Pain is defined by the International Association for the Study of Pain (IASP) as 'an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage'. Inflammation is the tissue's immunologic response to injury, characterized by mobilization of white blood cells and antibodies, swelling, and fluid accumulation.

Pain and Inflammation Research Products Areas

Products for Pain and Inflammation Research

  1. Cat.No. Product Name Activity
  2. BCC5904 Bombinakinin M Potent bradykinin receptor agonist Bombinakinin M
  3. BCC5996 Sar-[D-Phe8]-des-Arg9-Bradykinin Potent and selective B1 agonist Sar-[D-Phe8]-des-Arg9-Bradykinin
  4. BCC5995 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin Selective B2 agonist [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
  5. BCC5993 Lys-Bradykinin Potent bradykinin receptor agonist (B2 > B1) Lys-Bradykinin
  6. BCC5991 Lys-[Des-Arg9]Bradykinin Selective B1 agonist Lys-[Des-Arg9]Bradykinin
  7. BCC5964 HOE 140 Potent and selective B2 antagonist HOE 140
  8. BCC6094 MEN 11270 Selective B2 antagonist; analog of HOE 140 MEN 11270
  9. BCC3819 Noscapine HCl Bradykinin antagonist. Also tubulin inhibitor Noscapine HCl
  10. BCC6014 R 715 Potent and selective B1 antagonist R 715
  11. BCC5992 R 892 Potent and selective B1 antagonist R 892
  12. BCC6914 WIN 64338 hydrochloride Bradykinin B2 antagonist WIN 64338 hydrochloride
  13. BCC5903 Bombinakinin-GAP Bioactive, bradykinin-related peptide Bombinakinin-GAP
  14. BCC5269 Acetaminophen Cyclooxygenase inhibitor; may be selective for COX-3 Acetaminophen
  15. BCC2097 Aspirin (Acetylsalicylic acid) Cyclooxygenase inhibitor; NSAID Aspirin (Acetylsalicylic acid)
  16. BCC1099 Celecoxib Selective cyclooxygenase-2 (COX-2) inhibitor Celecoxib
  17. BCC4439 Diclofenac Sodium Cyclooxygenase inhibitor; NSAID Diclofenac Sodium
  18. BCC7064 DuP 697 Cyclooxygenase-2 (COX-2) inhibitor DuP 697
  19. BCC4428 Etodolac Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID Etodolac
  20. BCC1576 FK 3311 Cyclooxygenase-2 (COX-2) inhibitor FK 3311
  21. BCC3781 Flurbiprofen Cyclooxygenase inhibitor Flurbiprofen
  22. BCC7092 FR 122047 hydrochloride Cyclooxygenase (COX-1) inhibitor FR 122047 hydrochloride
  23. BCC4042 (S)-(+)-Ibuprofen Cyclooxygenase inhibitor (COX-1 > COX-2) (S)-(+)-Ibuprofen
  24. BCC3794 Indomethacin Cyclooxygenase inhibitor (COX-1 > COX-2) Indomethacin
  25. BCC6490 Naproxen Sodium Cyclooxygenase inhibitor Naproxen Sodium
  26. BCC7944 NCX 4040 NO-donating aspirin; anti-inflammatory and antitumor NCX 4040
  27. BCC6219 NCX 466 Cyclooxygenase-inhibiting nitric oxide donor NCX 466
  28. BCC6857 NS 398 Cyclooxygenase-2 (COX-2) inhibitor NS 398
  29. BCC3841 Piroxicam Cyclooxygenase-1 (COX-1) inhibitor Piroxicam
  30. BCN5607 Resveratrol Cyclooxygenase inhibitor Resveratrol
  31. BCC7111 SC 560 Cyclooxygenase-1 (COX-1) inhibitor SC 560
  32. BCC5948 SC 58125 Selective cyclooxygenase-2 (COX-2) inhibitor SC 58125
  33. BCC7809 SC 236 Selective cyclooxygenase-2 (COX-2) inhibitor SC 236
  34. BCC4861 Sulindac Cyclooxygenase inhibitor (following metabolism to sulindac sulfide) Sulindac
  35. BCC7391 Talniflumate Cyclooxygenase inhibitor. Also chloride channel blocker Talniflumate
  36. BCC7419 Tenidap NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3 Tenidap
  37. BCC4441 Valdecoxib Selective and potent COX-2 inhibitor Valdecoxib
  38. BCC5812 AF 12198 Potent, selective human type I IL-1 receptor antagonist AF 12198
  39. BCC7149 YM 90709 Interleukin-5 receptor antagonist YM 90709
  40. BCC5895 Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable Lyn peptide inhibitor
  41. BCC5813 Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Rα receptor interaction Ro 26-4550 trifluoroacetate
  42. BCC1327 Acamprosate calcium GABA agonist and glutamatergic modulator Acamprosate calcium
  43. BCC4503 (R)-baclofen Selective GABAB agonist. Active enantiomer of (RS)-Baclofen (R)-baclofen
  44. BCN2187 4-Aminobutanoic acid Endogenous agonist 4-Aminobutanoic acid
  45. BCC6012 RuBi-GABA Caged GABA; excitable by visible wavelength RuBi-GABA
  46. BCC6626 SKF 97541 Extremely potent GABAB agonist SKF 97541
  47. BCC6988 CGP 35348 Brain penetrant, selective GABAB antagonist CGP 35348
  48. BCC7605 CGP 36216 hydrochloride GABAB antagonist; displays activity at presynaptic receptors CGP 36216 hydrochloride
  49. BCC6990 CGP 46381 Brain penetrant, selective GABAB antagonist CGP 46381
  50. BCC6989 CGP 52432 Potent, selective GABAB antagonist CGP 52432
  51. BCC6934 CGP 54626 hydrochloride Potent, selective GABAB antagonist CGP 54626 hydrochloride
  52. BCC5737 CGP 55845 hydrochloride Potent, selective GABAB antagonist CGP 55845 hydrochloride
  53. BCC6579 2-Hydroxysaclofen Selective GABAB antagonist, more potent than saclofen 2-Hydroxysaclofen
  54. BCC6562 Phaclofen Weak, selective GABAB antagonist Phaclofen
  55. BCC6580 Saclofen Selective GABAB antagonist Saclofen
  56. BCC5692 SCH 50911 Selective, competitive, orally active GABAB antagonist SCH 50911
  57. BCC7644 rac BHFF Potent, selective GABAB positive allosteric modulator rac BHFF
  58. BCC7097 CGP 13501 Positive modulator at GABAB receptors CGP 13501
  59. BCC7096 CGP 7930 Positive modulator at GABAB receptors CGP 7930
  60. BCC7233 GS 39783 Positive modulator at GABAB receptors GS 39783
  61. BCC7186 N-ArachidonylGABA Inhibits pain in vivo N-ArachidonylGABA
  62. BCC3783 Gabapentin Anticonvulsant. Increases brain GABA Gabapentin
  63. BCC6629 3-Methyl-GABA Activator of GABA amino-transferase 3-Methyl-GABA
  64. BCC6794 NCS-382 Antagonist of γ -hydroxybutyric acid NCS-382
  65. BCC6231 Pentobarbital sodium salt Enhances GABAergic activity Pentobarbital sodium salt
  66. BCC7453 Pentylenetetrazole CNS stimulant Pentylenetetrazole
  67. BCC6230 Phenobarbital sodium salt Enhances GABAergic activity Phenobarbital sodium salt
  68. BCC2156 Valproic acid sodium salt (Sodium valproate) Increases GABA levels; anticonvulsant Valproic acid sodium salt (Sodium valproate)
  69. BCC2512 Zonisamide Anticonvulsant, modulates GABA neurotransmission Zonisamide
  70. BCN2203 Corticosterone Endogenous glucocorticoid Corticosterone
  71. BCC4907 Fluticasone propionate Selective high affinity glucocorticoid receptor agonist Fluticasone propionate
  72. BCC6115 GSK 9027 Glucocorticoid receptor agonist GSK 9027
  73. BCC2256 Methylprednisolone Glucocorticoid receptor agonist Methylprednisolone
  74. BCC4801 Mometasone furoate Synthetic corticosteroid; anti-inflammatory agent Mometasone furoate
  75. BCC4486 Mifepristone Glucocorticoid and progesterone receptor antagonist Mifepristone
  76. BCC4767 Budesonide Synthetic glucocorticoid; anti-inflammatory and chemopreventive Budesonide
  77. BCC1184 Dexamethasone (DHAP) Anti-inflammatory glucocorticoid Dexamethasone (DHAP)
  78. BCN2192 Hydrocortisone Adrenal glucocorticoid; immunosuppressant Hydrocortisone
  79. BCC1659 IRAK-1-4 Inhibitor I IRAK4 and IRAK1 inhibitor IRAK-1-4 Inhibitor I
  80. BCC7576 BAY-u 9773 Dual CysLT1 and CysLT2 antagonist BAY-u 9773
  81. BCC7244 Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active Cinalukast
  82. BCC7310 FPL 55712 Leukotriene receptor antagonist FPL 55712
  83. BCC7334 MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor MK 571
  84. BCC4680 Montelukast Sodium CysLT1 and GPR17 antagonist Montelukast Sodium
  85. BCC4827 Pranlukast Selective CysLT1 antagonist Pranlukast
  86. BCC7180 SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist SR 2640 hydrochloride
  87. BCC6274 Gue 1654 Selective inhibitor of OXE-R Gβ γ signaling Gue 1654
  88. BCN2215 Arachidonic acid Endogenous free fatty acid (in water-soluble emulsion) Arachidonic acid
  89. BCC6038 BAY-X 1005 Orally active 5-lipoxygenase activating protein (FLAP) inhibitor BAY-X 1005
  90. BCC7457 Cilastatin sodium Dipeptidase inhibitor; inhibits metabolism of LTD4 to LTE4 Cilastatin sodium
  91. BCC7017 MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) MK 886
  92. BCC6717 17-ODYA LTB ω -hydroxylase inhibitor 17-ODYA
  93. BCN5599 Baicalein 5- and 12-Lipoxygenase inhibitor Baicalein
  94. BCC7013 BW-B 70C 5-Lipoxygenase inhibitor BW-B 70C
  95. BCC7504 PD 146176 Selective 15-lipoxygenase inhibitor PD 146176
  96. BCC7288 STEARDA Endogenous inhibitor of 5-lipoxygenase STEARDA
  97. BCC6735 2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor 2-TEDC
  98. BCC2515 Zileuton Orally active 5-LOX inhibitor Zileuton
  99. BCC6223 ACHP Selective IKKα and IKKβ inhibitor; blocks NF-κ B-DNA binding ACHP
  100. BCN6291 Arctigenin Inhibitor of Iκ Bα phosphorylation. Also inhibits MEK1 Arctigenin
  101. BCC5105 Bay 11-7085 Irreversible inhibitor of TNF-α -induced Iκ Bα phosphorylation Bay 11-7085

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