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Cancer Research

Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.

Cancer Research Products Areas

Products for Cancer Research

  1. Cat.No. Product Name Activity
  2. BCN2964 Cyclopamine Inhibitor of Hedgehog (Hh) signaling; depletes stem-like cancer cells in glioblastoma Cyclopamine
  3. BCC2125 Geldanamycin Selective Hsp90 inhibitor; breast cancer stem cell inhibitor Geldanamycin
  4. BCC3987 ML 239 Breast cancer stem cell inhibitor ML 239
  5. BCC6525 Napabucasin Blocks cancer stem cell self-renewal; STAT3 inhibitor Napabucasin
  6. BCC5081 Niclosamide Inhibits AML stem cells; STAT3 and mTORC1 signaling inhibitor Niclosamide
  7. BCC7880 SC 26196 Selective Δ 6 desaturase inhibitor; eliminates cancer stem cells from ovarian cancer cell lines SC 26196
  8. BCC4850 STF-118804 Depletes leukemia stem cells; NAMPT inhibitor STF-118804
  9. BCC3869 Thioridazine HCl Selective inducer of CSC differentiation; anticancer agent Thioridazine HCl
  10. BCC3690 Verteporfin Suppresses cancer stem cell properties; YAP inhibitor Verteporfin
  11. BCC7882 CP 100356 hydrochloride P-gp inhibitor CP 100356 hydrochloride
  12. BCC1547 Elacridar hydrochloride P-gp inhibitor Elacridar hydrochloride
  13. BCC7719 Estropipate Estrogen receptor agonist and OATP1B1 inhibitor Estropipate
  14. BCC7507 Fumitremorgin C Inhibitor of BCRP-mediated multidrug resistance Fumitremorgin C
  15. BCC1684 Ko 143 Potent and selective BCRP inhibitor Ko 143
  16. BCC7874 KS 176 Selective BCRP inhibitor KS 176
  17. BCC7334 MK 571 MRP1 inhibitor; also CysLT1 (LTD4) inverse agonist MK 571
  18. BCC4832 Probenecid MRP inhibitor Probenecid
  19. BCC2027 Valspodar Inhibitor of P-gp-mediated MDR Valspodar
  20. BCC2307 Pyrimethamine Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor Pyrimethamine
  21. BCC7764 Reversan Selective MRP1 and P-gp inhibitor Reversan
  22. BCC1001 Adrenomedullin (1-12), human Potent P-glycoprotein (P-gp) inhibitor Adrenomedullin (1-12), human
  23. BCC3878 LY335979 (Zosuquidar 3HCL) High affinity P-gp inhibitor LY335979 (Zosuquidar 3HCL)
  24. BCN2961 Ingenol 3-Angelate Substrate for MDR; also protein kinase C activator Ingenol 3-Angelate
  25. BCC2383 R18 Inhibitor of 14.3.3 proteins R18
  26. BCC2385 Actinomycin D Antineoplastic antibiotic Actinomycin D
  27. BCC3599 Apicidin Potent histone deacetylase inhibitor; induces apoptosis Apicidin
  28. BCC2099 Apoptosis Activator 2 Selectively induces tumor cell apoptosis Apoptosis Activator 2
  29. BCC1375 AT-101 Downregulates Bcl-2 and Mcl-1; pro-apoptotic AT-101
  30. BCC1397 BAM7 Selective Bax activator; induces Bax-mediated apoptosis BAM7
  31. BCC1153 Bendamustine HCl Cytostatic agent; exhibits DNA alkylating and purine analog properties Bendamustine HCl
  32. BCN5524 Betulinic acid Antitumor and anti-HIV agent; activates NF-κ B. Also TGR5 agonist Betulinic acid
  33. BCC2386 C 75 Induces apoptosis and exhibits anti-tumor activity C 75
  34. BCC1170 Carboplatin DNA cross-linking antitumor agent Carboplatin
  35. BCC8017 CFM 4 CARP-1 mimetic; proapoptotic CFM 4
  36. BCC2387 CHM 1 Potent antitumor agent; inducer of apoptosis CHM 1
  37. BCN1552 Cisplatin DNA-alkylating antitumor agent Cisplatin
  38. BCC1173 Cladribine Deoxyadenosine analog; pro-apoptotic Cladribine
  39. BCN5504 Curcumin Antitumor, anti-inflammatory and antioxidant Curcumin
  40. BCC1185 Cyclophosphamide Alkylating agent; chemotherapeutic Cyclophosphamide
  41. BCN4804 Deguelin Anticancer and antiviral agent; chemopreventive and pro-apoptotic Deguelin
  42. BCC1117 Doxorubicin (Adriamycin) HCl Antitumor antibiotic agent; induces apoptosis Doxorubicin (Adriamycin) HCl
  43. BCC2518 Fludarabine Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression Fludarabine
  44. BCN2318 Gambogic acid Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins Gambogic acid
  45. BCN5653 Kaempferol Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter Kaempferol
  46. BCC2228 2-Methoxyestradiol (2-MeOE2) Apoptotic and antiangiogenic agent 2-Methoxyestradiol (2-MeOE2)
  47. BCC2388 Mitomycin C DNA cross-linking antitumor agent Mitomycin C
  48. BCC8040 MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor MPC 6827 hydrochloride
  49. BCN4732 Narciclasine Antiproliferative agent; exhibits pro-apoptotic effects Narciclasine
  50. BCC2389 NSC 687852 (b-AP15) Inhibitor UCHL5 and USP14; induces apoptosis NSC 687852 (b-AP15)
  51. BCN5616 Oleanolic acid Selective GPBA receptor (TGR5) partial agonist; apoptosis inducer Oleanolic acid
  52. BCC2390 Oncrasin 1 Proapoptotic; induces abnormal nuclear accumulation of PKC? Oncrasin 1
  53. BCC3932 Oxaliplatin DNA cross-linking antitumor agent Oxaliplatin
  54. BCC2148 PCI-34051 Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines PCI-34051
  55. BCN4037 Piplartine Induces apoptosis; increases p53 and ROS levels in cancer cells Piplartine
  56. BCN2586 Plumbagin Induces apoptosis; anticancer Plumbagin
  57. BCC3848 Rifaximin (Xifaxan) Apoptosis inducer; pregnane X receptor agonist and antibiotic Rifaximin (Xifaxan)
  58. BCN3834 Streptozotocin DNA alkylator; antitumor and induces diabetes Streptozotocin
  59. BCC4386 Temozolomide DNA-methylating antitumor agent Temozolomide
  60. BCC2005 Toceranib Potent PDGFR and VEGFR inhibitor; induces apoptosis Toceranib
  61. BCC2257 TW-37 Bcl-2 inhibitor; induces apoptosis TW-37
  62. BCC2391 ARRY 520 trifluoroacetate Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation ARRY 520 trifluoroacetate
  63. BCC2394 Bax inhibitor peptide V5 Inhibitor of Bax-mediated apoptosis Bax inhibitor peptide V5
  64. BCC2395 Bax inhibitor peptide, negative control Negative control peptide for Bax inhibitor peptide V5 Bax inhibitor peptide, negative control
  65. BCC3593 HA14-1 Bcl-2 inhibitor. Induces apoptosis HA14-1
  66. BCC4098 Marinopyrrole A Mcl-1 inhibitor; proapoptotic Marinopyrrole A
  67. BCC2256 Methylprednisolone Anti-apoptotic; upregulates expression of Bcl-xL after injury Methylprednisolone
  68. BCN2702 Gossypol Proapoptotic; downregulates Bcl-2 and Bcl-XL Gossypol
  69. BCC2397 Muristerone A Stimulates Bcl-XL mRNA transcription; antiapoptotic Muristerone A
  70. BCC2398 SU 9516 Transcriptionally downregulates Mcl-1; proapoptotic SU 9516
  71. BCC2356 AZ 10417808 Selective non-peptide caspase-3 inhibitor AZ 10417808
  72. BCC1126 Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor Z-VAD-FMK
  73. BCC2358 Ac-IEPD-AFC Fluorogenic granzyme B substrate Ac-IEPD-AFC
  74. BCC2359 Ac-LEHD-AFC Fluorogenic caspase substrate Ac-LEHD-AFC
  75. BCC3600 PAC-1 Activator of procaspase-3; pro-apoptotic PAC-1
  76. BCC2360 PETCM Activator of caspase-3 PETCM
  77. BCN2678 Embelin Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor Embelin
  78. BCC8042 UC 112 IAP and XIAP inhibitor; antitumor UC 112
  79. BCN5984 Triptolide Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive Triptolide
  80. BCC2241 Pifithrin-? (PFT?) p53 inhibitor. Also aryl hydrocarbon receptor agonist Pifithrin-? (PFT?)
  81. BCC2407 Cyclic Pifithrin-? hydrobromide p53 inhibitor Cyclic Pifithrin-? hydrobromide
  82. BCC2412 Pifithrin-? Inhibitor of p53-mitochondrial binding Pifithrin-?
  83. BCC2408 HLI 373 Hdm2 inhibitor; activates p53-dependent transcription HLI 373
  84. BCC2410 NSC 146109 hydrochloride Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription NSC 146109 hydrochloride
  85. BCC2242 NSC 319726 Reactivator of mutant p53 NSC 319726
  86. BCC2255 NSC 66811 MDM2 inhibitor. Disrupts MDM2-p53 interaction NSC 66811
  87. BCC2238 RITA (NSC 652287) p53-MDM2 interaction inhibitor; antitumor RITA (NSC 652287)
  88. BCC2416 SJ 172550 MDMX inhibitor. Disrupts MDMX-p53 interaction SJ 172550
  89. BCC2239 Tenovin-1 Activates p53 transcriptional activity Tenovin-1
  90. BCC2417 WR 1065 p53 activator. Also ROS scavenger WR 1065
  91. BCC5580 BMH-21 p53 pathway activator; also RNA polymerase 1 inhibitor BMH-21
  92. BCC2406 CP 31398 dihydrochloride p53-stabilizing agent CP 31398 dihydrochloride
  93. BCC2409 MIRA-1 Restores mutant p53 activity; proapoptotic MIRA-1
  94. BCC2411 PhiKan 083 p53 stabilizing agent PhiKan 083
  95. BCC2413 PRIMA-1 Restores mutant p53 activity; induces apoptosis PRIMA-1
  96. BCC2414 PRIMA-1MET Restores mutant p53 activity PRIMA-1MET
  97. BCC6131 SCH 529074 Restores mutant p53 activity SCH 529074
  98. BCC2399 Cesium chloride Potassium channel blocker; neuroprotective Cesium chloride
  99. BCC3911 CGK733 Induces apoptosis in prematurely senescent cells CGK733
  100. BCC2400 DAPK Substrate Peptide Death associated protein kinase substrate (synthetic) DAPK Substrate Peptide
  101. BCC1306 3,3'-Diindolylmethane Activates Chk2; induces apoptosis 3,3'-Diindolylmethane

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