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Membrane Transporter/Ion Channel

Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins)

Products for Membrane Transporter/Ion Channel

  1. Cat.No. Product Name Information
  2. BCC1660 Istaroxime Istaroxime (PST2744) is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM. Istaroxime
  3. BCC7993 BCH LAT1-IN-1 (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. BCH
  4. BCC5735 DL-TBOA DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA
  5. BCC5779 L-R4W2 L-R4W2
  6. BCC3625 Tariquidar Tariquidar is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM). Tariquidar
  7. BCC7510 TB 21007 TB 21007
  8. BCC6619 (±)-1-(1,2-Diphenylethyl)piperidine maleate (±)-1-(1,2-Diphenylethyl)piperidine maleate
  9. BCC6749 iso-PPADS tetrasodium salt P2X antagonist iso-PPADS tetrasodium salt
  10. BCN5359 Digoxin Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure treatment. Digoxin
  11. BCC5002 Gliclazide Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Gliclazide is used as an antidiabetic. Gliclazide
  12. BCC7532 CX 546 CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. CX 546
  13. BCC1559 Esomeprazole Magnesium trihydrate Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. Esomeprazole Magnesium trihydrate
  14. BCC1560 Etifoxine Etifoxine(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. Etifoxine
  15. BCC7706 PD 173212 PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. PD 173212
  16. BCC5106 BTB06584 BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase. BTB06584
  17. BCC5990 ShK-Dap22 ShK-Dap22
  18. BCC6584 ACBC ACBC
  19. BCC7817 YM 58483 YM-58483 is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM 58483
  20. BCC6974 IDRA 21 IDRA 21
  21. BCC6759 Cyclothiazide Cyclothiazide
  22. BCC4298 Lansoprazole sodium Lansoprazole sodium(AG-1749) is a proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole sodium
  23. BCC7646 AZ 11645373 Potent and selective human P2X7 antagonist AZ 11645373
  24. BCC7294 (±)-HIP-A (±)-HIP-A
  25. BCC7295 (±)-HIP-B (±)-HIP-B
  26. BCC6688 Ifenprodil hemitartrate Ifenprodil hemitartrate
  27. BCC6170 MK 0343 MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic. MK 0343
  28. BCC5067 Ambroxol HCl Na+ channel blocker,AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3. Ambroxol HCl
  29. BCC7545 Alphaxalone Alphaxalone
  30. BCC6889 QX 314 bromide QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker. QX 314 bromide
  31. BCC7461 Zoniporide dihydrochloride Zoniporide dihydrochloride
  32. BCC7141 Apamin Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin
  33. BCC5782 pep2m pep2m
  34. BCC5783 pep4c pep4c
  35. BCN2325 Nonivamide Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests. Nonivamide
  36. BCC6685 trans-4-Hydroxycrotonic acid trans-4-Hydroxycrotonic acid
  37. BCC6032 N2-Methyl-L-arginine N2-Methyl-L-arginine
  38. BCC1751 Miriplatin hydrate Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents. Miriplatin hydrate
  39. BCC7675 AM 1172 FAAH inhibitor; also anandamide uptake inhibitor and CB receptor partial agonist AM 1172
  40. BCC5740 Tertiapin-Q Tertiapin-Q
  41. BCC4904 Felbamate Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). Felbamate
  42. BCC6591 Ibotenic acid Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. Ibotenic acid
  43. BCC7885 IEM 1925 dihydrobromide IEM 1925 dihydrobromide
  44. BCC5898 CALP2 CALP2
  45. BCC5900 CALP3 CALP3, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia. CALP3
  46. BCC4788 Indapamide Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. Indapamide
  47. BCC6593 Muscimol Potent GABAA agonist Muscimol
  48. BCC7994 CHC CHC
  49. BCC1119 Bumetanide Bumetanide (Ro 10-6338;PF 1593) is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively. Bumetanide
  50. BCC7617 L-838,417 L-838,417
  51. BCC5077 Oxcarbazepine Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. Oxcarbazepine
  52. BCC1943 Senicapoc Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM. Senicapoc
  53. BCC1122 TRAM-34 TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM). TRAM-34
  54. BCC3785 Glipizide Glipizide(K 4024; CP 2872) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. Glipizide
  55. BCC7794 Licarbazepine Licarbazepine
  56. BCC4378 Carbamazepine Carbamazepine, a sodium channel blocker, is an anticonvulsant drug. Carbamazepine
  57. BCN1749 Hypotaurine Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Hypotaurine
  58. BCC7482 TCS 46b TCS 46b
  59. BCC7008 Ochratoxin A Ochratoxin A
  60. BCC1088 Dynasore Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM. Dynasore
  61. BCC4398 Flunarizine 2HCl Flunarizine is a selective calcium entry blocker. Flunarizine 2HCl
  62. BCC6864 Spermine tetrahydrochloride Spermine tetrahydrochloride is an endogenous metabolite. Spermine tetrahydrochloride
  63. BCC4419 CFTRinh-172 CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM. CFTRinh-172
  64. BCC6358 ICA 121431 ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM). ICA 121431
  65. BCC7764 Reversan Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor. Reversan
  66. BCC7803 VU 590 dihydrochloride VU 590 dihydrochloride
  67. BCC7499 PD 118057 PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade. PD 118057
  68. BCC7044 VDM 11 VDM 11
  69. BCC6815 Evans Blue tetrasodium salt Selective P2X purinergic antagonist,Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue tetrasodium salt
  70. BCC7266 SCS SCS
  71. BCC6338 ICA 110381 ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM). ICA 110381
  72. BCC7720 Indiplon Indiplon
  73. BCC4104 GlyH-101 GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. GlyH-101
  74. BCC5784 pep2-SVKI pep2-SVKI
  75. BCC7816 TCS 5861528 Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). TCS 5861528
  76. BCC6276 ML SA1 ML SA1
  77. BCC5003 Gliquidone Gliquidone (AR-DF 26) is an anti-diabetic drug in the sulfonylurea class, used in the treatment of diabetes mellitus type 2. Gliquidone
  78. BCC6865 Spermidine trihydrochloride Spermidine trihydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine trihydrochloride significantly decreases the H2O2 and O2.- contents. Spermidine trihydrochloride
  79. BCC7114 6'-Iodoresiniferatoxin 6'-Iodoresiniferatoxin
  80. BCC7930 (S)-(+)-Ketamine hydrochloride (S)-(+)-Ketamine hydrochloride
  81. BCC6909 1-BCP 1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents. 1-BCP is a memory-enhancing agent. 1-BCP
  82. BCC5079 Propafenone HCl Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias. Propafenone HCl
  83. BCC6190 NS 3623 NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS 3623
  84. BCC6323 Optovin Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM). Optovin
  85. BCC4910 HC-030031 HC-030031 is a potent and selective TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively. HC-030031
  86. BCC6307 NS 6180 NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation. NS 6180
  87. BCC7819 TCS 1205 TCS 1205
  88. BCC7546 Valerenic acid Valerenic acid
  89. BCC5497 Brivaracetam Brivaracetam
  90. BCC1803 NNC 55-0396 NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. NNC 55-0396
  91. BCC6868 Diazoxide Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment. Diazoxide
  92. BCC4074 Icilin Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel. Icilin
  93. BCC6563 ZAPA sulfate ZAPA sulfate
  94. BCC7748 DS2 DS2
  95. BCC1661 Istaroxime hydrochloride Istaroxime hydrochloride is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM. Istaroxime hydrochloride
  96. BCC5377 LY451395 Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors. LY451395
  97. BCC1725 LY450108 LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. LY450108
  98. BCC7516 NBMPR NBMPR
  99. BCC6205 DQP 1105 DQP 1105
  100. BCC6151 CMPDA CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor. CMPDA
  101. BCC6564 TACA TACA

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