WindorphenWnt inhibitor CAS# 19881-70-0 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 19881-70-0 | SDF | Download SDF |
| PubChem ID | 735821 | Appearance | Powder |
| Formula | C17H15ClO3 | M.Wt | 302.75 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | >11.45mg/mL in DMSO | ||
| Chemical Name | (E)-3-chloro-2,3-bis(4-methoxyphenyl)prop-2-enal | ||
| SMILES | COC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)OC)Cl)C=O | ||
| Standard InChIKey | VNRALGZMXHFBPG-MSUUIHNZSA-N | ||
| Standard InChI | InChI=1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Windorphen Dilution Calculator
Windorphen Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3031 mL | 16.5153 mL | 33.0306 mL | 66.0611 mL | 82.5764 mL |
| 5 mM | 0.6606 mL | 3.3031 mL | 6.6061 mL | 13.2122 mL | 16.5153 mL |
| 10 mM | 0.3303 mL | 1.6515 mL | 3.3031 mL | 6.6061 mL | 8.2576 mL |
| 50 mM | 0.0661 mL | 0.3303 mL | 0.6606 mL | 1.3212 mL | 1.6515 mL |
| 100 mM | 0.033 mL | 0.1652 mL | 0.3303 mL | 0.6606 mL | 0.8258 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling for ventral development.
Wnt protein is a family of signaling proteins that interacts on the Wnt/β-Catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.
In canonical Wnt/β-catenin reporter cell line STF293, Windorphen dose-dependently inhibits Wnt3a-inducible TOPFLASH-luciferase activity (IC50 of 1.5 mM). In human colon adenocarcinoma
SW480 cells with defective APC gene that constitutively activates Wnt signaling, 72 h treatment of Windorphen causes a wide spread apoptosis. [1]
In zebrafish embryos, Windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). Windorphen selectively inhibits Wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). In addition, Windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective Axin1/β-catenin destruction complex causes abnormal activation of Wnt signaling and the loss of telencephalon and eyes.) [1]
Reference:
1. Hao J, Ao A, Zhou L et al. Selective small molecule targeting β-catenin function discovered by in
vivo chemical genetic screen. Cell Rep. 2013 Sep 12;4(5):898-904.
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Selective small molecule targeting beta-catenin function discovered by in vivo chemical genetic screen.[Pubmed:24012757]
Cell Rep. 2013 Sep 12;4(5):898-904.
The canonical Wnt signaling pathway, mediated by the transcription factor beta-catenin, plays critical roles in embryonic development and represents an important therapeutic target. In a zebrafish-based in vivo screen for small molecules that specifically perturb embryonic dorsoventral patterning, we discovered a compound named Windorphen that selectively blocks the Wnt signal required for ventral development. Windorphen exhibits remarkable specificity toward beta-catenin-1 function, indicating that the two beta-catenin isoforms found in zebrafish are not functionally redundant. We show that Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with beta-catenin. Finally, Windorphen robustly and selectively kills cancer cells that harbor Wnt-activating mutations, supporting the therapeutic potential of this Wnt inhibitor class.
