SUN-B 8155Non-peptide calcitonin (CT) receptor agonist CAS# 345893-91-6 |
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Chemical structure
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| Cas No. | 345893-91-6 | SDF | Download SDF |
| PubChem ID | 16079007 | Appearance | Powder |
| Formula | C14H15N3O3 | M.Wt | 273.29 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | (3Z)-3-[1-(2-aminoanilino)ethylidene]-1-hydroxy-4-methylpyridine-2,6-dione | ||
| SMILES | CC1=CC(=O)N(C(=O)C1=C(C)NC2=CC=CC=C2N)O | ||
| Standard InChIKey | IMUCOECFKIWBSW-LCYFTJDESA-N | ||
| Standard InChI | InChI=1S/C14H15N3O3/c1-8-7-12(18)17(20)14(19)13(8)9(2)16-11-6-4-3-5-10(11)15/h3-7,16,20H,15H2,1-2H3/b13-9- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Non-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC50 = 21 μM). Causes a significant reduction in serum calcium concentrations in vivo following i.p. administration. |
SUN-B 8155 Dilution Calculator
SUN-B 8155 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6591 mL | 18.2956 mL | 36.5912 mL | 73.1823 mL | 91.4779 mL |
| 5 mM | 0.7318 mL | 3.6591 mL | 7.3182 mL | 14.6365 mL | 18.2956 mL |
| 10 mM | 0.3659 mL | 1.8296 mL | 3.6591 mL | 7.3182 mL | 9.1478 mL |
| 50 mM | 0.0732 mL | 0.3659 mL | 0.7318 mL | 1.4636 mL | 1.8296 mL |
| 100 mM | 0.0366 mL | 0.183 mL | 0.3659 mL | 0.7318 mL | 0.9148 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin.[Pubmed:11325540]
Biochim Biophys Acta. 2001 May 3;1526(2):183-90.
Calcitonin (CT), a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis. To discover non-peptide small molecules with biological actions similar to those of CT, a cell-based screening of an in-house chemical library was performed and a pyridone derivative (SUN B8155) was identified. Like CT, it elevated cyclic AMP (cAMP) levels in T47D and UMR106-06 cells which endogenously express human and rat CT receptor, respectively. SUN B8155 also stimulated cAMP formation in cells expressing recombinant human CT receptor, but not in those expressing human parathyroid hormone/parathyroid hormone-related peptide receptor. Accumulation of cAMP in T47D cells was blocked by a selective antagonist of CT receptor, salmon CT(8-32), whereas SUN B8155 did not displace the specific binding of [(125)I]CT to the receptor. Our results suggested that the compound selectively interacts with the CT receptor by a mechanism similar to but probably different from that of CT itself. In rats, intraperitoneal administration of SUN B8155 significantly lowered serum calcium levels, like CT. Our results demonstrate, for the first time, that the biological activities of the newly identified small molecule can mimic that of CT, acting via the CT receptor.
