S-Ruxolitinib (INCB018424)JAK1/2 inhibitor,potent and selective CAS# 941685-37-6 |
Related Products
- CYT387 sulfate salt
Catalog No.:BCC1506
CAS No.:1056636-06-6
- Baricitinib phosphate
Catalog No.:BCC1401
CAS No.:1187595-84-1
- JAK2 Inhibitor V, Z3
Catalog No.:BCC1667
CAS No.:195371-52-9
- Bardoxolone methyl
Catalog No.:BCC1400
CAS No.:218600-53-4
- Ruxolitinib (INCB018424)
Catalog No.:BCC1276
CAS No.:941678-49-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 941685-37-6 | SDF | Download SDF |
| PubChem ID | 50878566 | Appearance | Powder |
| Formula | C17H18N6 | M.Wt | 306.37 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | S-Ruxolitinib; INCB18424 | ||
| Solubility | DMSO : ≥ 100 mg/mL (326.40 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile | ||
| SMILES | C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 | ||
| Standard InChIKey | HFNKQEVNSGCOJV-HNNXBMFYSA-N | ||
| Standard InChI | InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | S-Ruxolitinib is the chirality of INCB018424. | |||||
| Targets | JAK1 | JAK2 | JAK3 | |||
| IC50 | 3.3 nM | 2.8 nM | 428 nM | |||
S-Ruxolitinib (INCB018424) Dilution Calculator
S-Ruxolitinib (INCB018424) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.264 mL | 16.3201 mL | 32.6403 mL | 65.2805 mL | 81.6007 mL |
| 5 mM | 0.6528 mL | 3.264 mL | 6.5281 mL | 13.0561 mL | 16.3201 mL |
| 10 mM | 0.3264 mL | 1.632 mL | 3.264 mL | 6.5281 mL | 8.1601 mL |
| 50 mM | 0.0653 mL | 0.3264 mL | 0.6528 mL | 1.3056 mL | 1.632 mL |
| 100 mM | 0.0326 mL | 0.1632 mL | 0.3264 mL | 0.6528 mL | 0.816 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor. It was initially developed to target the constitutive activation of the JAK-STAT pathway. Janus kinases (JAKs) are a family of cytoplasmic tyrosine kinases that mediates signals from the receptors for various cytokines and growth factors that have a key role in haematopoiesis and immune function. Ruxolitinib maintains its anti-JAK activity by competitive inhibition of the ATP-binding catalytic site of the kinase domain. Ruxolitinib is well absorbed at >95%. Exposure of JAK2V617F-positive Ba/F3 cells to ruxolitinib iss shown to result in reduced cellular proliferation.
References
Ruben A. Mesa, Uma Yasothan, Peter Kirkpatrick. Ruxolitinib. Nature Reviews Drug Discovery. 2012; 11: 103-104
John Mascarenhas, Ronald Hoffman. Ruxolitinib: The First FDA Approved Therapy for the Treatment of Myelofibrosis. Clinical Cancer Research. 2012; 18(11): 3008 - 3014
Featured Products
- INCB032304
Catalog No.:BCC6455
CAS No.:941685-27-4
- Ruxolitinib (INCB018424)
Catalog No.:BCC1276
CAS No.:941678-49-5
- Selaginellin
Catalog No.:BCN8215
CAS No.:941269-84-7
- 1,3,5-Cadinatriene-3,8-diol
Catalog No.:BCN4486
CAS No.:941227-27-6
- 1'-Acetonaphthone
Catalog No.:BCC8446
CAS No.:941-98-0
- KD 5170
Catalog No.:BCC2420
CAS No.:940943-37-3
- SB743921
Catalog No.:BCC4559
CAS No.:940929-33-9
- R-7128
Catalog No.:BCC1880
CAS No.:940908-79-2
- Poliumoside
Catalog No.:BCN1204
CAS No.:94079-81-9
- Suplatast Tosylate
Catalog No.:BCC4961
CAS No.:94055-76-2
- NVP-BHG712
Catalog No.:BCC3963
CAS No.:940310-85-0
- N,N'-Bis(salicylidene)ethylenediamine
Catalog No.:BCC9064
CAS No.:94-93-9
New Products
- 8beta-(4'-Hydroxytigloyloxy)costunolide
Catalog No.:BCN7885
CAS No.:94190-32-6
- Methyl 3-indolecarboxylate
Catalog No.:BCN4487
CAS No.:942-24-5
- VTP-27999
Catalog No.:BCC2048
CAS No.:942142-51-0
- SCH772984
Catalog No.:BCC1935
CAS No.:942183-80-4
- PI 828
Catalog No.:BCC7494
CAS No.:942289-87-4
- 20-Dehydroeupatoriopicrin semiacetal
Catalog No.:BCN7370
CAS No.:94234-24-9
- Scutebarbatine I
Catalog No.:BCN1026
CAS No.:960302-84-5
- Cycloart-24-ene-1alpha,2alpha,3beta-triol
Catalog No.:BCN7983
CAS No.:942407-97-8
- VKGILS-NH2
Catalog No.:BCC3953
CAS No.:942413-05-0
- Nemoralisin
Catalog No.:BCN4488
CAS No.:942480-13-9
- PF-03814735
Catalog No.:BCC2184
CAS No.:942487-16-3
- Walsuronoid B
Catalog No.:BCN4489
CAS No.:942582-15-2
Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib S enantiomer is a JAK inhibitor
S-Ruxolitinib (INCB018424),941685-37-6,S-Ruxolitinib; INCB18424,Natural Products,JAK, buy S-Ruxolitinib (INCB018424) , S-Ruxolitinib (INCB018424) supplier , purchase S-Ruxolitinib (INCB018424) , S-Ruxolitinib (INCB018424) cost , S-Ruxolitinib (INCB018424) manufacturer , order S-Ruxolitinib (INCB018424) , high purity S-Ruxolitinib (INCB018424)
