NSC 207895 (XI-006)MDMX inhibitor,anti-cancer agent CAS# 58131-57-0 |
- RETRA hydrochloride
Catalog No.:BCC2415
CAS No.:1036069-26-7
- Tenovin-1
Catalog No.:BCC2239
CAS No.:380315-80-0
- Pifithrin-α (PFTα)
Catalog No.:BCC2241
CAS No.:63208-82-2
- NSC 319726
Catalog No.:BCC2242
CAS No.:71555-25-4
- PhiKan 083
Catalog No.:BCC2411
CAS No.:880813-36-5
- JNJ-26854165 (Serdemetan)
Catalog No.:BCC2240
CAS No.:881202-45-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 58131-57-0 | SDF | Download SDF |
| PubChem ID | 42640 | Appearance | Powder |
| Formula | C11H13N5O4 | M.Wt | 279.25 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 0.4 mg/mL (1.43 mM) in DMSO | ||
| Chemical Name | 4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium | ||
| SMILES | CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-] | ||
| Standard InChIKey | MWFZDJLPWDCQIL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C11H13N5O4/c1-13-4-6-14(7-5-13)9-3-2-8(15(17)18)10-11(9)16(19)20-12-10/h2-3H,4-7H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | NSC 207895 is an anticancer agent. | |||||
| Targets | E3 ligase MDM2 | MDMX | ||||
NSC 207895 (XI-006) Dilution Calculator
NSC 207895 (XI-006) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.581 mL | 17.9051 mL | 35.8102 mL | 71.6204 mL | 89.5255 mL |
| 5 mM | 0.7162 mL | 3.581 mL | 7.162 mL | 14.3241 mL | 17.9051 mL |
| 10 mM | 0.3581 mL | 1.7905 mL | 3.581 mL | 7.162 mL | 8.9526 mL |
| 50 mM | 0.0716 mL | 0.3581 mL | 0.7162 mL | 1.4324 mL | 1.7905 mL |
| 100 mM | 0.0358 mL | 0.1791 mL | 0.3581 mL | 0.7162 mL | 0.8953 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
NSC 207895 is a small-molecule inhibitor of MDMX with GI50 value of 117nM [1].
NSC 207895 is a benzofuroxan derivative and is less toxic. NSC 207895 decreases the activity of MDMX promoter and subsequently decreases both the mRNA and protein levels of MDMX in MCF-7 cells. This inhibition of MDMX is accompanied with the activation of p53. NSC 207895 induces apoptosis in MCF-7 cells since it induces pro-apoptotic gene expression. It is found that the cleavage of PARP is significantly induced by NSC 207895 [2].
NSC 207895 is also found to be a DNA-damaging agent. It shows strong functional interactions with both DNA repair and replication fork complexes. NSC 207895 activates the DNA damage response (DDR) and leads a delay in cell cycle progression [3].
References:
[1] Hawes JJ, Nerva JD, Reilly KM. Novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds. J Biomol Screen. 2008 Sep;13(8):795-803.
[2] Wang H, Ma X, Ren S, Buolamwini JK, Yan C. A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Mol Cancer Ther. 2011 Jan;10(1):69-79.
[3] Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451.
- 2-Hydroxynaringenin
Catalog No.:BCN4820
CAS No.:58124-18-8
- SU 4312
Catalog No.:BCC7073
CAS No.:5812-07-7
- Aurantiamide
Catalog No.:BCN5790
CAS No.:58115-31-4
- 1-(4-(3-Chloropropoxy)-3-methoxyphenyl)ethanone
Catalog No.:BCC8406
CAS No.:58113-30-7
- Fmoc-Arg(NO2)-OH
Catalog No.:BCC2596
CAS No.:58111-94-7
- Undulatoside A
Catalog No.:BCN6773
CAS No.:58108-99-9
- Isonicoteine
Catalog No.:BCN2152
CAS No.:581-50-0
- Anatabine
Catalog No.:BCN6899
CAS No.:581-49-7
- Suberosin
Catalog No.:BCN5791
CAS No.:581-31-7
- α-MSH
Catalog No.:BCC7420
CAS No.:581-05-5
- trans-3,4-Methylenedioxycinnamyl alcohol
Catalog No.:BCN1410
CAS No.:58095-76-4
- Miltefosine
Catalog No.:BCC4360
CAS No.:58066-85-6
- Militarine
Catalog No.:BCN2551
CAS No.:58139-23-4
- Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
Catalog No.:BCC8975
CAS No.:58168-20-0
- Idebenone
Catalog No.:BCC4913
CAS No.:58186-27-9
- H-DL-Ser-OMe.HCl
Catalog No.:BCC3100
CAS No.:5819-04-5
- Tetraethyl ranelate
Catalog No.:BCC9177
CAS No.:58194-26-6
- Betulin palmitate
Catalog No.:BCN5792
CAS No.:582315-55-7
- BMS265246
Catalog No.:BCC3741
CAS No.:582315-72-8
- ICA 069673
Catalog No.:BCC7911
CAS No.:582323-16-8
- Kakkalide
Catalog No.:BCN8263
CAS No.:58274-56-9
- Nanaomycin C
Catalog No.:BCC4016
CAS No.:58286-55-8
- Kusunokinin
Catalog No.:BCN3226
CAS No.:58311-20-9
- Saikosaponin B2
Catalog No.:BCN5916
CAS No.:58316-41-9
