Mubritinib (TAK 165)Potent and selective ErbB2 inhibitor CAS# 366017-09-6 |
Related Products
- mGlu2 agonist
Catalog No.:BCC1745
CAS No.:1311385-32-6
- LY341495
Catalog No.:BCC1724
CAS No.:201943-63-7
- MPEP Hydrochloride
Catalog No.:BCC1777
CAS No.:219911-35-0
- CPPHA
Catalog No.:BCC1501
CAS No.:693288-97-0
- Dipraglurant
Catalog No.:BCC1531
CAS No.:872363-17-2
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 366017-09-6 | SDF | Download SDF |
| PubChem ID | 6444692 | Appearance | Powder |
| Formula | C25H23F3N4O2 | M.Wt | 468.47 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Mubritinib | ||
| Solubility | DMSO : 50 mg/mL (106.73 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||
| Chemical Name | 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole | ||
| SMILES | C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F | ||
| Standard InChIKey | ZTFBIUXIQYRUNT-MDWZMJQESA-N | ||
| Standard InChI | InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. |
Mubritinib (TAK 165) Dilution Calculator
Mubritinib (TAK 165) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1346 mL | 10.673 mL | 21.3461 mL | 42.6922 mL | 53.3652 mL |
| 5 mM | 0.4269 mL | 2.1346 mL | 4.2692 mL | 8.5384 mL | 10.673 mL |
| 10 mM | 0.2135 mL | 1.0673 mL | 2.1346 mL | 4.2692 mL | 5.3365 mL |
| 50 mM | 0.0427 mL | 0.2135 mL | 0.4269 mL | 0.8538 mL | 1.0673 mL |
| 100 mM | 0.0213 mL | 0.1067 mL | 0.2135 mL | 0.4269 mL | 0.5337 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk.
Featured Products
- AY 9944 dihydrochloride
Catalog No.:BCC3940
CAS No.:366-93-8
- Procarbazine HCl
Catalog No.:BCC4452
CAS No.:366-70-1
- H-Arg-OEt.2HCl
Catalog No.:BCC2860
CAS No.:36589-29-4
- Ac-Tyr-OEt.H2O
Catalog No.:BCC3121
CAS No.:36546-50-6
- Cycloheterophyllin
Catalog No.:BCN4640
CAS No.:36545-53-6
- Guaiacin
Catalog No.:BCN4127
CAS No.:36531-08-5
- Serpentinine
Catalog No.:BCN5325
CAS No.:36519-42-3
- Emiline
Catalog No.:BCN2080
CAS No.:36506-99-7
- beta-Costic acid
Catalog No.:BCN5324
CAS No.:3650-43-9
- Agatholal
Catalog No.:BCN5323
CAS No.:3650-31-5
- Carnosic acid
Catalog No.:BCN5892
CAS No.:3650-09-7
- Methylsynephrine Hydrochloride
Catalog No.:BCN3407
CAS No.:365-26-4
New Products
- 1,4-Benzodioxan-2-carboxylic acid
Catalog No.:BCC8421
CAS No.:3663-80-7
- Semialactone
Catalog No.:BCN5422
CAS No.:366450-46-6
- 1-Hexadecanol
Catalog No.:BCC4616
CAS No.:36653-82-4
- Rivaroxaban
Catalog No.:BCC2292
CAS No.:366789-02-8
- Cussosaponin C
Catalog No.:BCN2895
CAS No.:366814-42-8
- Pulchinenoside E
Catalog No.:BCN8165
CAS No.:366814-43-9
- Isorhamnetin 3-glucuronide
Catalog No.:BCN2709
CAS No.:36687-76-0
- Benzyl 2,4-dihydroxyphenyl ketone
Catalog No.:BCC8867
CAS No.:3669-41-8
- 8-Shogaol
Catalog No.:BCN3266
CAS No.:36700-45-5
- Beta-Solamarine
Catalog No.:BCN2693
CAS No.:3671-38-3
- Boc-Phe-Osu
Catalog No.:BCC2601
CAS No.:3674-06-4
- Boc-D-Phe-Osu
Catalog No.:BCC2600
CAS No.:3674-18-8
Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer.[Pubmed:12850190]
Lancet Oncol. 2003 Jul;4(7):397-406.
Despite aggressive surgical and chemotherapeutic interventions, non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death in men and women with overall cure rates of less than 15%. Recent advances in our understanding of cellular signalling and its critical role in tumorigenesis has led to the development of novel therapies which may offer new hope. In particular, the epidermal growth-factor receptor superfamily is an attractive therapeutic target because it is commonly overexpressed in malignant disease, regulates many vital cellular processes, and seems to be a negative prognostic indicator. Several selective inhibitors of this family of receptors are currently being evaluated in several cancers including NSCLC. In this review we examine current preclinical and clinical evidence on monoclonal antibodies (cetuximab, ABX-EGF, EMD72000, MAb ICR62, h-R3, MDX-447, MDX-H210, trastuzumab, and 2C4), immunoconjugates (Y10, Ua30:2, Mab806), anti-EGF vaccine (YMB2000), and tyrosine kinase inhibitors (gefitinib, erlotinib, CI1033, GW572016, EKB 569, PKI166, PD158780, and TAK 165).
Mubritinib (TAK-165) is a potent and selective EGFR2/HER2 inhibitor with an IC50 of 6 nM.
Mubritinib (TAK 165),366017-09-6,Mubritinib,Natural Products,HER2, buy Mubritinib (TAK 165) , Mubritinib (TAK 165) supplier , purchase Mubritinib (TAK 165) , Mubritinib (TAK 165) cost , Mubritinib (TAK 165) manufacturer , order Mubritinib (TAK 165) , high purity Mubritinib (TAK 165)
