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Ivachtin

Caspase-3 inhibitor CAS# 745046-84-8

Ivachtin

Catalog No. BCC2357----Order now to get a substantial discount!

Product Name & Size Price Stock
Ivachtin:1mg $102.00 In stock
Ivachtin:2mg $173.00 In stock
Ivachtin:5mg $408.00 In stock
Ivachtin:10mg $714.00 In stock
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Quality Control of Ivachtin

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Chemical structure

Ivachtin

3D structure

Chemical Properties of Ivachtin

Cas No. 745046-84-8 SDF Download SDF
PubChem ID 11201705 Appearance Powder
Formula C20H21N3O7S M.Wt 447.46
Type of Compound N/A Storage Desiccate at -20°C
Solubility Limited solubility
Chemical Name 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
SMILES CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C
Standard InChIKey MWXJJTMEUGWKKY-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Ivachtin

DescriptionPotent, reversible inhibitor of caspase-3 (IC50 = 23 nM) that displays moderate selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine; exhibits a higher level of protection than Z-VAD-FMK .

Ivachtin Dilution Calculator

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Ivachtin Molarity Calculator

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Preparing Stock Solutions of Ivachtin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2348 mL 11.1742 mL 22.3484 mL 44.6967 mL 55.8709 mL
5 mM 0.447 mL 2.2348 mL 4.4697 mL 8.9393 mL 11.1742 mL
10 mM 0.2235 mL 1.1174 mL 2.2348 mL 4.4697 mL 5.5871 mL
50 mM 0.0447 mL 0.2235 mL 0.447 mL 0.8939 mL 1.1174 mL
100 mM 0.0223 mL 0.1117 mL 0.2235 mL 0.447 mL 0.5587 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Ivachtin

Ivachtin is a potent inhibitor of caspase-3 with IC50 value of 23 nM [1].

Caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. Sequential activation of caspases plays an important role in cell apoptosis.

Ivachtin is a potent and reversible inhibitor of caspase-3 in a noncompetitive way. Ivachtin was the most potent inhibitor against caspase-3, but the selectivity versus the remaining caspases was modest. In human Jurkat T cells treated with 10 μM staurosporin, Ivachtin protected cells in a higher level, which suggested that Ivachtin had a good cell permeability and antiapoptotic activity [1].

Reference:
[1]. Kravchenko DV, Kuzovkova YA, Kysil VM, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem, 2005, 48(11): 3680-3683.

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Description

Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases.

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