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Cobimetinib (R-enantiomer)

Selective MEK inhibitor CAS# 934660-94-3

Cobimetinib (R-enantiomer)

Catalog No. BCC1493----Order now to get a substantial discount!

Product Name & Size Price Stock
Cobimetinib (R-enantiomer):5mg $201.00 In stock
Cobimetinib (R-enantiomer):10mg $342.00 In stock
Cobimetinib (R-enantiomer):25mg $804.00 In stock
Cobimetinib (R-enantiomer):50mg $1407.00 In stock
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Quality Control of Cobimetinib (R-enantiomer)

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Chemical structure

Cobimetinib (R-enantiomer)

3D structure

Chemical Properties of Cobimetinib (R-enantiomer)

Cas No. 934660-94-3 SDF Download SDF
PubChem ID 16222097 Appearance Powder
Formula C21H21F3IN3O2 M.Wt 531.31
Type of Compound N/A Storage Desiccate at -20°C
Synonyms GDC-0973 R-enantiomer; XL-518 R-enantiomer
Solubility DMSO : ≥ 100 mg/mL (188.21 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2R)-piperidin-2-yl]azetidin-1-yl]methanone
SMILES C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Standard InChIKey BSMCAPRUBJMWDF-QGZVFWFLSA-N
Standard InChI InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Cobimetinib (R-enantiomer)

DescriptionCobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.

References:
[1]. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.

Cobimetinib (R-enantiomer) Dilution Calculator

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Cobimetinib (R-enantiomer) Molarity Calculator

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Preparing Stock Solutions of Cobimetinib (R-enantiomer)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8821 mL 9.4107 mL 18.8214 mL 37.6428 mL 47.0535 mL
5 mM 0.3764 mL 1.8821 mL 3.7643 mL 7.5286 mL 9.4107 mL
10 mM 0.1882 mL 0.9411 mL 1.8821 mL 3.7643 mL 4.7054 mL
50 mM 0.0376 mL 0.1882 mL 0.3764 mL 0.7529 mL 0.9411 mL
100 mM 0.0188 mL 0.0941 mL 0.1882 mL 0.3764 mL 0.4705 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Cobimetinib (R-enantiomer)

GDC-0973(XL-518) is a selective inhibitor of MEK. GDC-0973 is also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.

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Description

Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.

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