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Cefoselis hydrochloride

CAS# 911212-25-4

Cefoselis hydrochloride

Catalog No. BCC4093----Order now to get a substantial discount!

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Chemical structure

Cefoselis hydrochloride

3D structure

Chemical Properties of Cefoselis hydrochloride

Cas No. 911212-25-4 SDF Download SDF
PubChem ID 78358333 Appearance Powder
Formula C19H23ClN8O6S2 M.Wt 559.02
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
Chemical Name (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[2-(2-hydroxyethyl)-3-iminopyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrochloride
SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.Cl
Standard InChIKey NRCXQSKOHNLPOW-ZQCAECPKSA-N
Standard InChI InChI=1S/C19H22N8O6S2.ClH/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28;/h2-3,8,13,17,20,28H,4-7H2,1H3,(H2,21,22)(H,23,29)(H,31,32);1H/b20-11?,24-12-;/t13-,17-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Cefoselis hydrochloride

DescriptionCefoselis is a widely used beta-lactam antibiotic. Target: Antibacterial Cefoselis, a new parenteral cephalosporin, was active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. The activity of Cefoselis was similar to that of cefpirome and cefepime and generally superior to that of ceftazidime. Cefoselis showed potent antibacterial activity against Hemophilus influenzae and Moraxella catarrhalis.Cefoselis was highly active against MSSA and MSCNS. Cefoselis was poor in the activity against MRSA,MRCNS,PRSP and Enterococcus faecalis,and no activity for Enterococcus faecium.

References:
[1]. King, A., L. Bethune, and I. Phillips, The Comparative In Vitro Activity of FK-037 (Cefoselis), a New Broad-Spectrum Cephalosporin. Clin Microbiol Infect, 1995. 1(1): p. 13-17. [2]. ZHU, D., et al., In vitro activities of cefoselis compared to β-lactams and other antibacterial agents aganst gram-positive and gram-negative clinical isolates. Chinese Journal of Infection and Chemotherapy, 2011. 4: p. 002.

Cefoselis hydrochloride Dilution Calculator

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Cefoselis hydrochloride Molarity Calculator

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Preparing Stock Solutions of Cefoselis hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7888 mL 8.9442 mL 17.8884 mL 35.7769 mL 44.7211 mL
5 mM 0.3578 mL 1.7888 mL 3.5777 mL 7.1554 mL 8.9442 mL
10 mM 0.1789 mL 0.8944 mL 1.7888 mL 3.5777 mL 4.4721 mL
50 mM 0.0358 mL 0.1789 mL 0.3578 mL 0.7155 mL 0.8944 mL
100 mM 0.0179 mL 0.0894 mL 0.1789 mL 0.3578 mL 0.4472 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Cefoselis hydrochloride

Cefoselis is a widely used beta-lactam antibiotic.

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Cefoselis is a widely used beta-lactam antibiotic.

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