BMS-538203HIV integrase inhibitor,highly efficient CAS# 543730-41-2 |
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| Cas No. | 543730-41-2 | SDF | Download SDF |
| PubChem ID | 54706524 | Appearance | Powder |
| Formula | C12H12FNO5 | M.Wt | 269.23 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 54 mg/mL (200.57 mM); | ||
| Chemical Name | (Z)-4-[(4-fluorophenyl)methyl-methoxyamino]-2-hydroxy-4-oxobut-2-enoic acid | ||
| SMILES | CON(CC1=CC=C(C=C1)F)C(=O)C=C(C(=O)O)O | ||
| Standard InChIKey | GACIOSIZKMLELV-POHAHGRESA-N | ||
| Standard InChI | InChI=1S/C12H12FNO5/c1-19-14(11(16)6-10(15)12(17)18)7-8-2-4-9(13)5-3-8/h2-6,15H,7H2,1H3,(H,17,18)/b10-6- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent.
IC50 value:
Target: HIV integrase
In the current study we demonstrate a hit-to-clinical candidate pathway that resulted in 50- and 2000-fold improvements in enzyme-inhibition and antiviral activity without an increase in molecular weight or change in molecular topology. The original hit , 1 (mw = 268) was optimized in a stepwise manner. Potential covalent protein-binding moieties were removed by reducing the number of the ketone groups. High enzyme inhibition activity was achieved by optimizing the aryl-portion of the molecule. Protein binding was reduced by replacing the standard amide by the corresponding methyl-hydroxamide. This eventually led to the discovery of BMS-538203 compound 2 (mw = 269) a highly efficient inhibitor and antiviral agent. References: | |||||
BMS-538203 Dilution Calculator
BMS-538203 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7143 mL | 18.5715 mL | 37.143 mL | 74.2859 mL | 92.8574 mL |
| 5 mM | 0.7429 mL | 3.7143 mL | 7.4286 mL | 14.8572 mL | 18.5715 mL |
| 10 mM | 0.3714 mL | 1.8571 mL | 3.7143 mL | 7.4286 mL | 9.2857 mL |
| 50 mM | 0.0743 mL | 0.3714 mL | 0.7429 mL | 1.4857 mL | 1.8571 mL |
| 100 mM | 0.0371 mL | 0.1857 mL | 0.3714 mL | 0.7429 mL | 0.9286 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent.
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BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent.
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