Anamorelin hydrochlorideGHSR/ghrelin receptor agonist CAS# 861998-00-7 |
- Ibutamoren Mesylate
Catalog No.:BCC1638
CAS No.:159752-10-0
- Anamorelin
Catalog No.:BCC1362
CAS No.:249921-19-5
- Anamorelin Fumarate
Catalog No.:BCC1363
CAS No.:339539-92-3
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 861998-00-7 | SDF | Download SDF |
| PubChem ID | 16072155 | Appearance | Powder |
| Formula | C31H43ClN6O3 | M.Wt | 583.16 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | RC-1291 hydrochloride; ONO-7643 hydrochloride | ||
| Solubility | DMSO : ≥ 28 mg/mL (48.01 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;hydrochloride | ||
| SMILES | CC(C)(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)N3CCCC(C3)(CC4=CC=CC=C4)C(=O)N(C)N(C)C)N.Cl | ||
| Standard InChIKey | VFYAEUWJFGTGGO-GHTUPXNNSA-N | ||
| Standard InChI | InChI=1S/C31H42N6O3.ClH/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22;/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39);1H/t26-,31-;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Anamorelin hydrochloride is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.In Vitro:In the FLIPR assay, Anamorelin (ANAM) shows significant agonist activity on the ghrelin receptor, with EC50 value of 0.74 nM. No significant antagonist activity is observed with Anamorelin at concentrations of up to 1,000 nM. In the binding experiments, Anamorelin binds to the ghrelin receptor with a binding affinity constant (Ki) of 0.70 nM. In the competition assay with radiolabeled ibutamoren (35S-MK-677; another ghrelin receptor agonist) Anamorelin (ANAM) is also found to bind with high affinity to the ghrelin receptor (IC50=0.69 nM). In rat pituitary cells incubated with Anamorelin, there is a dose-dependent stimulatory effect on GH release and the potency (EC50) is 1.5 nM. Anamorelin is screened for activity against a set of over 100 receptors, ion channels, transporters, and enzymes. Anamorelin demonstrates binding to the tachykinin neurokinin 2 (NK2) site (IC50=0.021 μM); however, a subsequent NK2 functional assay demonstrates no functional activity[1].In Vivo:In rats, Anamorelin (ANAM) at an oral dose of 3, 10, or 30 mg/kg once daily significantly increases both food intake and body weight from Day 2 to Day 7 of treatment compared with the vehicle control. The cumulative change in food intake and weight gain increases dose-dependently, and these changes are significant at all dose levels (P<0.05) compared to the control. Administration of Anamorelin at a single oral dose of 3, 10, or 30 mg/kg induces a dose-dependent increase in plasma GH levels and GH AUC0-6h in rats[1]. References: | |||||
Anamorelin hydrochloride Dilution Calculator
Anamorelin hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7148 mL | 8.574 mL | 17.148 mL | 34.2959 mL | 42.8699 mL |
| 5 mM | 0.343 mL | 1.7148 mL | 3.4296 mL | 6.8592 mL | 8.574 mL |
| 10 mM | 0.1715 mL | 0.8574 mL | 1.7148 mL | 3.4296 mL | 4.287 mL |
| 50 mM | 0.0343 mL | 0.1715 mL | 0.343 mL | 0.6859 mL | 0.8574 mL |
| 100 mM | 0.0171 mL | 0.0857 mL | 0.1715 mL | 0.343 mL | 0.4287 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.
- 7-Methoxy-3,4-dihydro-1-naphthalenylacetonitrile
Catalog No.:BCC8781
CAS No.:861960-34-1
- 2''-O-Beta-L-Galorientin
Catalog No.:BCN3804
CAS No.:861691-37-4
- A-740003
Catalog No.:BCC1322
CAS No.:861393-28-4
- SKF 86466 hydrochloride
Catalog No.:BCC7795
CAS No.:86129-54-6
- Fmoc-D-Trp-OH
Catalog No.:BCC3559
CAS No.:86123-11-7
- Fmoc-D-Phe-OH
Catalog No.:BCC3537
CAS No.:86123-10-6
- 5'-Fluoroindirubinoxime
Catalog No.:BCC6104
CAS No.:861214-33-7
- A 844606
Catalog No.:BCC6200
CAS No.:861119-08-6
- M617
Catalog No.:BCC5929
CAS No.:860790-38-1
- Fmoc-Trp-OPfp
Catalog No.:BCC3557
CAS No.:86069-87-6
- Fmoc-β-Homo-Pro-OH
Catalog No.:BCC2627
CAS No.:86069-86-5
- Fmoc-Glu(OtBu)-OPfp
Catalog No.:BCC3495
CAS No.:86061-04-3
- Nandrolone undecylate
Catalog No.:BCC9090
CAS No.:862-89-5
- Mirodenafil
Catalog No.:BCC5254
CAS No.:862189-95-5
- Valeriotriate B
Catalog No.:BCN6751
CAS No.:862255-64-9
- RA VII
Catalog No.:BCN3512
CAS No.:86229-97-2
- Imatinib hydrochloride
Catalog No.:BCC1644
CAS No.:862366-25-4
- LY2228820
Catalog No.:BCC2528
CAS No.:862507-23-1
- IKK-3 Inhibitor
Catalog No.:BCC1643
CAS No.:862812-98-4
- Salvianan
Catalog No.:BCN3545
CAS No.:862832-46-0
- Ganoderic acid TR
Catalog No.:BCN3207
CAS No.:862893-75-2
- Isoiridogermanal
Catalog No.:BCN7613
CAS No.:86293-25-6
- 10-Hydroxycanthin-6-one
Catalog No.:BCN3906
CAS No.:86293-41-6
- alpha-Amyrin acetate
Catalog No.:BCN4410
CAS No.:863-76-3
Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC.[Pubmed:25945893]
Expert Opin Pharmacother. 2015 Jun;16(8):1245-53.
INTRODUCTION: Cancer anorexia-cachexia syndrome (CACS) is associated with increased morbidity and mortality. Anamorelin is a novel, orally active ghrelin receptor agonist in clinical development for the treatment of CACS in NSCLC. The aim of this review is to summarize preclinical and clinical studies evaluating anamorelin as a potential promising treatment for CACS in NSCLC. AREAS COVERED: Pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability of anamorelin for the treatment of CACS in NSCLC were reviewed. Anamorelin administration may lead to increases in food intake, body weight and lean body mass, and a stimulatory effect on growth hormone secretion in NSCLC patients. Anamorelin is well tolerated with no dose-limiting toxicities identified to date. EXPERT OPINION: Targeting ghrelin receptors presents the advantage of potentially addressing multiple mechanisms of CACS simultaneously including appetite, muscle protein balance, adipose tissue metabolism, energy expenditure and inflammation. Clinical data suggest that anamorelin is well tolerated and it effectively increases appetite, body weight and lean mass in patients with advanced NSCLC. Long-term safety remains unknown at this time. The potential synergistic effects of anamorelin with nutritional support or exercise as well as its efficacy/safety in other tumor types are also unknown.
Anamorelin hydrochloride in the treatment of cancer anorexia-cachexia syndrome.[Pubmed:24472001]
Future Oncol. 2014 Apr;10(5):789-802.
Anamorelin hydrochloride is an orally active ghrelin receptor agonist in development by Helsinn, for the treatment of non-small-cell lung cancer (NSCLC) cachexia. In preclinical and clinical studies, the potent affinity of anamorelin for the ghrelin receptor is associated with significant appetite-enhancing activity and resultant improvements in body weight, lean body mass, and handgrip strength compared with placebo. The accompanying stimulatory effects on growth hormone and IGF-1 are not associated with tumor growth, and overall survival in patients with cancer is not compromised. Anamorelin is well tolerated with no dose-limiting toxicities identified to date. The findings of ongoing Phase III studies are needed to confirm the significant potential of anamorelin to treat NSCLC cachexia.
