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19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

Catalog No. BCN1411
Size Price Stock
20mg $298 In stock
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Quality Control of 19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

Chemical structure

19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

19-Nor-4-hydroxyabieta-8,11,13-trien-7-one Dilution Calculator

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Chemical Properties of 19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

Cas No. 57906-31-7 SDF Download SDF
Chemical Name (1S,4aS,10aR)-1-hydroxy-1,4a-dimethyl-7-propan-2-yl-3,4,10,10a-tetrahydro-2H-phenanthren-9-one
SMILES CC(C)C1=CC2=C(C=C1)C3(CCCC(C3CC2=O)(C)O)C
Standard InChIKey PTQFIYQNKVSVGM-QRVBRYPASA-N
Standard InChI InChI=1S/C19H26O2/c1-12(2)13-6-7-15-14(10-13)16(20)11-17-18(15,3)8-5-9-19(17,4)21/h6-7,10,12,17,21H,5,8-9,11H2,1-4H3/t17-,18-,19+/m1/s1
Type of Compound Diterpenoids Appearance Powder
Formula C19H26O2 M.Wt 286.4
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4916 mL 17.4581 mL 34.9162 mL 69.8324 mL 87.2905 mL
5 mM 0.6983 mL 3.4916 mL 6.9832 mL 13.9665 mL 17.4581 mL
10 mM 0.3492 mL 1.7458 mL 3.4916 mL 6.9832 mL 8.7291 mL
50 mM 0.0698 mL 0.3492 mL 0.6983 mL 1.3966 mL 1.7458 mL
100 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.6983 mL 0.8729 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

This product is isolated and purified from the heart wood of Pinus yunnanensis

References on 19-Nor-4-hydroxyabieta-8,11,13-trien-7-one

Simultaneous quantification of 11 active constituents in Shexiang Baoxin Pill by ultraperformance convergence chromatography combined with tandem mass spectrometry.[Pubmed: 28384605]


On account of the complexity of chemical constituents of Shexiang Baoxin Pill (SBP), a famous traditional Chinese medicine (TCM) formula, a novel and effective UPC2-MS/MS method was developed to simultaneously determine the content of 11 active compounds of SBP with outstanding separation ability. Eleven components in SBP, including 2 ginsenosides, 2 bile acids, 3 bufadienolides and 4 volatiles were detected by electrospray ionization tandem mass spectrometry in positive and negative ion modes with multiple reaction monitor (MRM). The analysis was performed at 30°C using an Acquity UPC2 Diol (3.0×50mm, 1.7μm) column with linear gradient elution (eluent A, CO2; eluent B, methanol containing 20mM ammonium acetate), back pressure of 2000 psi, flow rate of 1.2mL/min and the injection volume of 1.0μL. The method was extensively validated regarding the linearity (r≥0.9974), precision (≤3.11%), recovery (93.34-104.50%), repeatability (≤2.00%) and stability (≤4.20%). Using this method, 11 active compounds of SBP with different polarity were simultaneously quantified in one chromatography analysis within 8min. Statistical analysis of the effects of 11 compounds on the quality of SBP revealed that the content of cinnamaldehyde varied widely in different batches. This work presents an exemplary study for quality control of complex samples, especially for TCMs.

Access to percutaneous transluminal coronary angioplasty and 30-day mortality in patients with incident STEMI: Differentials by educational level and gender over 11 years.[Pubmed: 28384181]


Socioeconomic status and gender are associated with access to cardiac procedures and mortality after AMI, also in countries with universal health care systems. Our objective was to evaluate the association and trends of educational level or gender and the following outcomes: 1) access to PTCA; 2) 30-day mortality.

Insulin Resistance Predicts Cognitive Decline: An 11-Year Follow-up of a Nationally Representative Adult Population Sample.[Pubmed: 28381479]


The aim of this study was to examine whether insulin resistance, assessed by HOMA of insulin resistance (HOMA-IR), is an independent predictor of cognitive decline.

GNG11 (G-protein γ subunit 11) suppresses cell growth with induction of reactive oxygen species and abnormal nuclear morphology in human SUSM-1 cells.[Pubmed: 28380310]


Enforced expression of GNG11, G-protein γ subunit 11, induces cellular senescence in normal human diploid fibroblasts. We here examined the effect of the expression of GNG11 on the growth of immortalized human cell lines, and found that it suppressed the growth of SUSM-1 cells, but not of HeLa cells. We then compared these two cell lines to understand the molecular basis for the action of GNG11. We found that expression of GNG11 induced the generation of reactive oxygen species (ROS) and abnormal nuclear morphology in SUSM-1 cells but not in HeLa cells. Increased ROS generation by GNG11 would likely be caused by the down-regulation of the antioxidant enzymes in SUSM-1 cells. We also found that SUSM-1 cells, even under normal culture conditions, showed higher levels of ROS and higher incidence of abnormal nuclear morphology than HeLa cells, and that abnormal nuclear morphology was relevant to the increased ROS generation in SUSM-1 cells. Thus, SUSM-1 and HeLa cells showed differences in the regulation of ROS and nuclear morphology, which might account for their different responses to the expression of GNG11. Then, SUSM-1 cells may provide a unique system to study the regulatory relationship between ROS generation, nuclear morphology, and G-protein signaling.

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