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19-Hydroxybaccatin III

19-Hydroxybaccatin III

Catalog No. BCN4330
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20mg $298 In stock
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Quality Control of 19-Hydroxybaccatin III

Chemical structure

19-Hydroxybaccatin III

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19-Hydroxybaccatin III Molarity Calculator



Chemical Properties of 19-Hydroxybaccatin III

Cas No. 78432-78-7 SDF Download SDF
SMILES CC(=O)O[C@@H]1C(=O)[C@@]2(CO)[C@H](O)C[C@@H]3OC[C@]3(OC(C)=O)C2C(OC(=O)c4ccccc4)C5(O)CC(O)C(=C1C5(C)C)C
Standard InChI InChI=1S/C31H38O12/c1-15-19(35)12-31(39)26(42-27(38)18-9-7-6-8-10-18)24-29(13-32,20(36)11-21-30(24,14-40-21)43-17(3)34)25(37)23(41-16(2)33)22(15)28(31,4)5/h6-10,19-21,23-24,26,32,35-36,39H,11-14H2,1-5H3/t19?,20-,21+,23+,24?,26?,29+,30-,31?/m1/s1
Type of Compound Diterpenoids Appearance Powder
Formula C31H38O12 M.Wt 602.6
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 19-Hydroxybaccatin III

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6595 mL 8.2974 mL 16.5948 mL 33.1895 mL 41.4869 mL
5 mM 0.3319 mL 1.6595 mL 3.319 mL 6.6379 mL 8.2974 mL
10 mM 0.1659 mL 0.8297 mL 1.6595 mL 3.319 mL 4.1487 mL
50 mM 0.0332 mL 0.1659 mL 0.3319 mL 0.6638 mL 0.8297 mL
100 mM 0.0166 mL 0.083 mL 0.1659 mL 0.3319 mL 0.4149 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 19-Hydroxybaccatin III

This product is isolated and purified from the barks of Taxus chinensis

References on 19-Hydroxybaccatin III

19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana.[Pubmed: 7264680]

Activity-guided, chromatographic fractionation for a polar extract of Taxus wallichiana Zucc. (originally identified as Cephalotaxus mannii Hook.) resulted in the isolation of three new KB cytotoxic taxane derivatives. Nmr and ms spectral analyses permitted their characterization as 19-Hydroxybaccatin III (3), 10-deacetylcephalomannine (4), and 10-deacetyltaxol (5). The latter two compounds, which are also active against PS leukemia in vivo, were observed to be especially labile, each forming equilibrium mixtures with their cytotoxic C-7 epimers (9, 10).

Structure-activity study on the actions of taxol and related taxanes on primary cultures of adrenal medullary cells.[Pubmed: 2564892]

Taxol is a natural plant product which has antimitotic activity. It is currently being investigated for use both as a cancer chemotherapy agent and as a tool to investigate microtubule involvement with various cellular functions. In the studies reported here, the actions of taxol on cultured adrenal medullary cells are compared to those of two other taxanes, baccatin III and 19-Hydroxybaccatin III, which are structurally similar but lacking a bulky ester linkage at the C13 position. Unlike taxol, baccatin III and 19-Hydroxybaccatin III have little or no known actions on mammalian microtubules. These studies were designed 1) to establish structural requirements for taxol's effects on adrenal cells and 2) to investigate whether the effects of taxol on adrenal cells involve microtubules. The effects of taxol on basal catecholamine release, on nicotinic receptor-stimulated catecholamine release and on the adrenal microtubule network are quantitatively and qualitatively different from those of baccatin III and 19-Hydroxybaccatin III.

Taxol and its related taxoids from the needles of Taxus sumatrana.[Pubmed: 7728941]

Through bioassay-guided separation of the chemical constituents of the needles of Taxus sumatrana, taxol (1), cephalomannine (2), and a new taxoid 19-hydroxy-13-oxobaccatin III (8) have been isolated together with 7-epi-10-deacetyltaxol (3), 7-epi-10-deacetylcephalomannine (4), baccatin III (5), 19-Hydroxybaccatin III (6), and 10-deacetyl-13-oxobaccatin III (7). The chemical structure of 8 has been elucidated on the bases of its chemical and physicochemical properties.


19-Hydroxybaccatin III ,78432-78-7,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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