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17-ODYALTB4 ω-hydroxylase inhibitor


Catalog No. BCC6717
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5mg $55.00 Ship Within 7 Days
10mg $99.00 Ship Within 7 Days
100mg $699.00 Ship Within 7 Days
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Quality Control of 17-ODYA

Chemical structure


Biological Activity of 17-ODYA

Potent suicide inhibitor of LTB4 ω-hydroxylase.

17-ODYA Dilution Calculator

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17-ODYA Molarity Calculator



Chemical Properties of 17-ODYA

Cas No. 34450-18-5 SDF Download SDF
Chemical Name 17-Octadecynoic acid
Standard InChI InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h1H,3-17H2,(H,19,20)
Formula C18H32O2 M.Wt 280.45
Solubility Soluble to 50 mM in ethanol and to 100 mM in DMSO
Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 17-ODYA

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5657 mL 17.8285 mL 35.657 mL 71.314 mL 89.1424 mL
5 mM 0.7131 mL 3.5657 mL 7.1314 mL 14.2628 mL 17.8285 mL
10 mM 0.3566 mL 1.7828 mL 3.5657 mL 7.1314 mL 8.9142 mL
50 mM 0.0713 mL 0.3566 mL 0.7131 mL 1.4263 mL 1.7828 mL
100 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.7131 mL 0.8914 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Background on 17-ODYA

17-ODYA is a potent inhibitor of cytochrome P450 fatty acid ω-hydroxylase [1].

ω-hydroxylase is a member of the cytochrome P450 superfamily of enzymes, which are monooxygenases that involved in synthesis of steroids, cholesterol and other lipids. ω-hydroxylase inactivates and degrades leukotriene B4, a potent mediator of inflammation.

In isolated single cells derived from rat portal vein, 17-ODYA (5 μM) inhibited delayed rectifier current (IK(V)) but didn’t influence A-type current (IK(A)). Also, 17-ODYA (5 μM) increased current flow through Ca-sensitive K-channel (BKCa) [2].

In renal cortical microsomes of rats, 17-ODYA inhibited the formation of epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid and dihydroxyeicosatrienoic acids with IC50 value < 100 nM. 17-ODYA inhibited the omega-hydroxylation of arachidonic acid by 61.3% and increased sodium excretion and urine flow [1]. In rabbit arteries with both endothelium-intact (E+) and endothelium-removal (E-), 17-ODYA increased the efficacy to angiotensin II. Also, 17-ODYA inhibited Ach-relaxation. 17-ODYA improved vasoconstrictor cyclooxygenase-2 metabolites release by inhibition of prostaglandin-ω-hydroxylase [3].

[1].  Zou AP, Ma YH, Sui ZH, et al. Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. J Pharmacol Exp Ther, 1994, 268(1): 474-481.
[2].  Edwards G, Zygmunt PM, Högestätt ED, et al. Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. Br J Pharmacol, 1996, 119(4): 691-701.
[3].  Jerez S, Sierra L, de Bruno MP. 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. Prostaglandins Other Lipid Mediat, 2012, 97(1-2): 36-42.


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