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Home >> Research Area >>Nature Products >> 15-Isopimarene-8,18-diol


Catalog No. BCN4287
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20mg $298 In stock
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Chemical Properties of 15-Isopimarene-8,18-diol

Cas No. 73002-86-5 SDF Download SDF
Chemical Name (1R,2S,4aS,4bR,7S,8aR,10aR)-7-ethenyl-1-(hydroxymethyl)-1,4a,7-trimethyl-2,3,4,4b,5,6,8,9,10,10a-decahydrophenanthrene-2,8a-diol
Standard InChI InChI=1S/C20H34O3/c1-5-17(2)9-6-15-18(3)10-8-16(22)19(4,13-21)14(18)7-11-20(15,23)12-17/h5,14-16,21-23H,1,6-13H2,2-4H3/t14-,15-,16+,17+,18+,19+,20-/m1/s1
Type of Compound Diterpenoids Appearance Powder
Formula C20H34O2 M.Wt 306.5
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 15-Isopimarene-8,18-diol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2626 mL 16.3132 mL 32.6264 mL 65.2529 mL 81.5661 mL
5 mM 0.6525 mL 3.2626 mL 6.5253 mL 13.0506 mL 16.3132 mL
10 mM 0.3263 mL 1.6313 mL 3.2626 mL 6.5253 mL 8.1566 mL
50 mM 0.0653 mL 0.3263 mL 0.6525 mL 1.3051 mL 1.6313 mL
100 mM 0.0326 mL 0.1631 mL 0.3263 mL 0.6525 mL 0.8157 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 15-Isopimarene-8,18-diol

This product is isolated and purified from the branch of Platycladus orientalis

References on 15-Isopimarene-8,18-diol

ent-5α,3,15-Dioxodolabr-4(18)-ene-16,18-diol.[Pubmed: 21589075]

The title compound, C(20)H(30)O(4), is a dolabrane diterpenoid isolated from Ceriops tagal, in which one of the three fused cyclo-hexane rings adopts a half-chair conformation and the other two are in the standard chair conformations. The hy-droxy-methyl-idene substituent is attached to the half-chair cyclo-hexane. An intra-molecular O-H⋯O hydrogen bond generate an S(6) ring motif. In the crystal, mol-ecules are arranged into screw chains along the [001] direction. The crystal is stabilized by O-H⋯O hydrogen bonds and weaker C-H⋯O inter-actions.

Acute and neurotoxicity of two structurally related acetylenic compounds: 5,7,11-dodecatriyn-1-ol and 5,7,11,13-octadecatetrayne-1,18-diol.[Pubmed: 3356863]

Two structurally related acetylenic compounds, 5,7,11-Dodecatriyn-1-ol, (Compound A), and 5,7,11,13-Octadecatetrayne-1,18-Diol (Compound B), were evaluated in a tier I toxicology testing program as part of an ongoing research and development program. This battery of acute tests included acute oral, guinea pig maximization, photosensitization, dermal irritation, Ames and multiple genetic endpoint and a 2 week oral fetotoxicity study. Compound A was found to have an oral LD50 of 0.25 ml/kg, be an extreme dermal sensitizer, a mild dermal irritant (PDII of 1.7), and not mutagenic or fetotoxic in the tests employed. Compound B had an oral LD50 greater than 4 g/kg, was a moderate dermal sensitizer and mild dermal irritant (PDII of 1.4), was not mutagenic in the Ames test but weakly increased the incidence of SCEs and gene mutations in Chinese Hamster Ovary cells, and was not fetotoxic. Neither compound was found to be a photosensitizer, but during the course of the photosensitization study Compound A was found to cause neuromuscular signs (including hind limb paralysis) and a bilateral necrosis of the medulla oblongata in female guinea pigs. A similar lesion was found in female rats receiving a single oral dose of 0.25 ml/kg and in nonpregnant females dosed daily for two weeks at 0.03 ml/kg. Compound B was not found to produce any of these neurologic effects.

Active principles of Tetradenia riparia; II. Antispasmodic activity of 8(14),15-sandaracopimaradiene-7 alpha,18-diol.[Pubmed: 3602140]

Active principles of Tetradenia riparia. I. Antimicrobial activity of 8(14),15-sandaracopimaradiene-7 alpha,18-diol.[Pubmed: 3807389]

Tetradenia riparia is one of the most popular medicinal plants in Rwanda. Previously, several new substances have been isolated from the leaves of this plant, including a new diterpene diol, i.e. 8(14),15-sandaracopimaradiene-7 alpha,18-diol. This new diterpene diol exhibits significant antimicrobial activity against several bacteria and fungi. The minimum inhibitory concentration (MIC) of the substance for microorganisms which were inhibited ranged from 6.25 to 100 micrograms/ml.


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