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Catalog No. BCN6176
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20mg $298 In stock
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Quality Control of 15-Demethylplumieride

Chemical structure


Biological Activity of 15-Demethylplumieride

1. 15-Demethylplumieride has cytotoxic activity.
2. 15-Demethylplumieride is HIV-1 and HIV-2 reverse transcriptases.

15-Demethylplumieride Dilution Calculator

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15-Demethylplumieride Molarity Calculator



Chemical Properties of 15-Demethylplumieride

Cas No. 132586-69-7 SDF Download SDF
SMILES C[C@@H](C1=C[C@@]2(C=C[C@H]3[C@@H]2[C@@H](OC=C3C(=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)OC1=O)O
Standard InChI InChI=1S/C20H24O12/c1-7(22)9-4-20(32-17(9)28)3-2-8-10(16(26)27)6-29-18(12(8)20)31-19-15(25)14(24)13(23)11(5-21)30-19/h2-4,6-8,11-15,18-19,21-25H,5H2,1H3,(H,26,27)/t7-,8+,11+,12+,13+,14-,15+,18-,19-,20+/m0/s1
Type of Compound Iridoids Appearance Powder
Formula C20H24O12 M.Wt 456.4
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 15-Demethylplumieride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1911 mL 10.9553 mL 21.9106 mL 43.8212 mL 54.7765 mL
5 mM 0.4382 mL 2.1911 mL 4.3821 mL 8.7642 mL 10.9553 mL
10 mM 0.2191 mL 1.0955 mL 2.1911 mL 4.3821 mL 5.4777 mL
50 mM 0.0438 mL 0.2191 mL 0.4382 mL 0.8764 mL 1.0955 mL
100 mM 0.0219 mL 0.1096 mL 0.2191 mL 0.4382 mL 0.5478 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 15-Demethylplumieride

This product is isolated and purified from the barks of Plumeria rubra

References on 15-Demethylplumieride

Isolation and characterization of secondary metabolites from Plumeria obtusa.[Pubmed: 22115036]

Chromatographic purification of the methanolic extract of Plumeria obtusa yielded two new iridoid obtusadoids A (1) and B (2), along with eight known compounds plumieridin A (3), plumieridine (4), 1α-plumieride (5), 15-Demethylplumieride (6), rel-(3R,3'S,4R,4'S)-3,3',4,4'-tetrahydro-6,6'-dimethoxy[3,3'-bi-2H-benzopyran]-4,4'-diol (7), glochiflavanoside B (8), oleanolic acid (9), and methyl coumarate (10). The structures of all the isolates (1-10) were determined by NMR spectroscopy and mass spectrometry. The data of known compounds (3-10) were further compared with the reported data for these compounds.

Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia.[Pubmed: 1965200]

By bioactivity-directed fractionation, six cytotoxic constituents have been characterized from the bark of Plumeria rubra collected in Indonesia. Three iridoids, fulvoplumierin [1], allamcin [2], and allamandin [3], as well as 2,5-dimethoxy-p-benzoquinone [4], were found to be active constituents of the P. rubra petroleum-ether- and CHCl3-soluble extracts. Cytotoxic compounds isolated from the H2O-soluble extract of the bark were the iridoid plumericin [5], and the lignan liriodendrin [6]. Each of these substances was found to demonstrate general cytotoxic activity when evaluated with a panel of cell lines composed of murine lymphocytic leukemia (P-388) and a number of human cancer cell-types (breast, colon, fibrosarcoma, lung, melanoma, KB). Five additional iridoids, 15-Demethylplumieride [7], plumieride [8], alpha-allamcidin [9], beta-allamcidin [10], and 13-O-trans-p-coumaroylplumieride [11], were obtained as inactive constituents. Compound 7 was found to be a novel natural product, and its structure was determined by spectroscopic methods and by conversion to plumieride [8]. The configuration of the C-4 stereocenter was unambiguously assigned for compounds 9 and 10, and certain nmr reassignments have been provided for compound 1.


15-Demethylplumieride ,132586-69-7,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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