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15,16-Dihydrotanshindiol C

15,16-Dihydrotanshindiol C

Catalog No. BCN3214
Size Price Stock
20mg $298 In stock
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Quality Control of 15,16-Dihydrotanshindiol C

Chemical structure

15,16-Dihydrotanshindiol C

15,16-Dihydrotanshindiol C Dilution Calculator

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15,16-Dihydrotanshindiol C Molarity Calculator

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Chemical Properties of 15,16-Dihydrotanshindiol C

Cas No. 891854-96-9 SDF Download SDF
SMILES CC1COC2=C1C(=O)C(=O)c3c2ccc4c3CC[C@H]([C@]4(C)O)O
Standard InChIKey HSWJBFKCVPRBJO-GNGYTGERSA-N
Standard InChI InChI=1S/C18H18O5/c1-8-7-23-17-10-3-5-11-9(4-6-12(19)18(11,2)22)14(10)16(21)15(20)13(8)17/h3,5,8,12,19,22H,4,6-7H2,1-2H3/t8?,12-,18-/m1/s1
Type of Compound Diterpenoids Appearance Red powder
Formula C18H18O5 M.Wt 314.3
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 15,16-Dihydrotanshindiol C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 15,16-Dihydrotanshindiol C

This product is isolated and purified from the roots of Salvia miltiorrhiza Bge.

References on 15,16-Dihydrotanshindiol C

[Molecular characterization of non-vaccine Streptococcus pneumoniae serotypes 11A, 15 B/C and 23A recovered from invasive isolates in Colombia].[Pubmed: 28968016]


A total of 192 invasive Streptococcus pneumoniae isolates, from serotypes 11A, 15B/C and 23A (not included in the conjugated vaccines), were collected in Colombia between 1994 and 2014 as part of the activities of the Network surveillance system for the causative agents of pneumonia and meningitis (SIREVA II).



A 15-amino acid C-terminal peptide of beta-defensin-3 inhibits bone resorption by inhibiting the osteoclast differentiation and disrupting podosome belt formation.[Pubmed: 28889177]


Human beta-defensin-3 (HBD3), which is secreted from cells in the skin, salivary gland, and bone marrow, exhibits antimicrobial and immunomodulatory activities. Its C-terminal end contains a 15-amino acid polypeptide (HBD3-C15) that is known to effectively elicit antimicrobial activity. Recently, certain antimicrobial peptides are known to inhibit osteoclast differentiation and, thus, we investigated whether HBD3-C15 hinders osteoclast differentiation and bone destruction to assess its potential use as an anti-bone resorption agent. HBD3-C15 inhibited the receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation and formation of resorption pits. In addition, HBD3-C15 disrupted the formation of RANKL-induced podosome belt which is a feature typically found in mature osteoclasts with bone-resorbing capacity. HBD3-C15 downregulated cortactin, cofilin, and vinculin, which are involved in the podosome belt formation. Furthermore, bone loss induced by RANKL was significantly reduced in a mouse calvarial implantation model that was treated with HBD3-C15. Similar inhibitory effects were observed on the osteoclast differentiation and podosome belt formation induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide (AaLPS). Concordantly, HBD3-C15 attenuated the resorption in the calvarial bone of AaLPS-implanted mouse. Collectively, these results suggest that HBD3-C15 has an anti-bone resorption effect in developing osteoclasts and that this occurs via its disruption of podosome belt formation. HBD3-C15 could be a potential therapeutic agent for the inhibition of bone destruction.



Corrigendum to "Accurate NMR determination of C-H or N-H distances for unlabeled molecules" [Solid State Nuclear Magnetic Resonance 73 (2016) 15-21].[Pubmed: 28870468]




Genomic sequences of two novel HLA-C alleles, HLA-C*15:143 and HLA-C*07:109:02.[Pubmed: 28858436]


Two novel HLA-C alleles, C*07:109:02 and C*15:143, were characterized in two Spanish individuals.



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