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Catalog No. BCN6002
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20mg $298 In stock
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Quality Control of 14,15-Didehydrovincamenine

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Chemical Properties of 14,15-Didehydrovincamenine

Cas No. 112219-48-4 SDF Download SDF
Standard InChI InChI=1S/C19H20N2/c1-2-19-9-5-11-20-12-8-15-14-6-3-4-7-16(14)21(13-10-19)17(15)18(19)20/h3-7,9-10,13,18H,2,8,11-12H2,1H3/t18-,19+/m1/s1
Type of Compound Alkaloids Appearance Powder
Formula C19H20N2 M.Wt 276.4
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 14,15-Didehydrovincamenine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6179 mL 18.0897 mL 36.1795 mL 72.3589 mL 90.4486 mL
5 mM 0.7236 mL 3.6179 mL 7.2359 mL 14.4718 mL 18.0897 mL
10 mM 0.3618 mL 1.809 mL 3.6179 mL 7.2359 mL 9.0449 mL
50 mM 0.0724 mL 0.3618 mL 0.7236 mL 1.4472 mL 1.809 mL
100 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.7236 mL 0.9045 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 14,15-Didehydrovincamenine

This product is isolated and purified from the herbs of Melodinus khasianus Hook. f.

References on 14,15-Didehydrovincamenine

Discovery of HLA-C*14:87, a novel HLA-C*14 variant, in a Taiwanese individual.[Pubmed: 29024503]

One nucleotide substitution at residue 526 of the HLA-C*14:15 results in a novel allele, HLA-C*14:87.

Functional Limitations Among Responders to the World Trade Center Attacks 14 Years After the Disaster: Implications of Chronic Posttraumatic Stress Disorder.[Pubmed: 29024005]

Posttraumatic stress disorder (PTSD) is associated with self-reported difficulties navigating the social and physical world and may also be associated with risk of functional limitations. The Short Physical Performance Battery (SPPB), an objective functional assessment, was administered during monitoring exams between January and December 2015 to a consecutive sample of 1,268 rescue workers, volunteers, and other responders who had aided in response, recovery, and cleanup efforts at the World Trade Center (WTC) in New York after the September 11, 2011 attacks. Data were linked with diagnostic and longitudinal data from the WTC monitoring study. Multivariable analyses were used to examine predictors of functional limitations. Prevalence estimates weighted to the general responder population revealed a relatively high prevalence of functional limitations, SPPB ≤ 9; 16.0%, 95% CI [13.7, 18.4]. Current PTSD was associated with a twofold increased risk of functional limitations after controlling for predisposing factors, trauma severity, behavioral factors, and WTC-related medical conditions, adjusted risk ratio (aRR) = 2.11, 95% CI [1.48, 3.01]. Exposure to ergonomic risk factors at the WTC also increased the risk of functional impairments, aRR = 1.34 95% CI [1.05, 1.70]. Longitudinal results suggest that individuals with current functional limitations experienced high baseline PTSD severity, B = 2.94, SE = 1.33, and increasing PTSD symptom severity, B = 0.29, SE = 0.10, since September 11, 2001. This study identified a cross-sectional relationship between functional limitations and PTSD and a worsening of PTSD symptoms in persons who eventually demonstrated functional limitations. Results highlight the potential role of chronic PTSD in functional limitations.

Filter quality of electret masks in filtering 14.6-594 nm aerosol particles: Effects of five decontamination methods.[Pubmed: 29023492]

This study investigates the effects of five decontamination methods on the filter quality (qf) of three commercially available electret masks-N95, Gauze and Spunlace nonwoven masks. Newly developed evaluation methods, the overall filter quality (qf,o) and the qf ratio were applied to evaluate the effectiveness of decontamination methods for respirators. A scanning mobility particle sizer is utilized to measure the concentration of polydispersed particles with diameter 14.6-594 nm. The penetration of particles and pressure drop (Δp) through the mask are used to determine qf and qf,o. Experimental results reveal that the most penetrating particle size (MPS) for the pre-decontaminated N95, Gauze and Spunlace masks were 118 nm, 461 nm and 279 nm, respectively, and the respective penetration rates were 2.6%, 23.2% and 70.0%. The Δp through the pretreated N95 masks was 9.2 mm H2O at the breathing flow rate of heavy-duty workers, exceeding the Δp values obtained through Gauze and Spunlace masks. Decontamination increased the sizes of the most penetrating particles, changing the qf values of all of the masks: qf fell as particle size increased because the penetration increased. Bleach increased the Δp of N95, but destroyed the Gauze mask. However, the use of an autoclave reduces the Δp values of both the N95 and the Gauze mask. Neither the rice cooker nor ethanol altered the Δp of the Gauze mask. Chemical decontamination methods reduced the qf,o values for the three electret masks. The value of qf,o for PM0.1 exceeded that for PM0.1-0.6, because particles smaller than 100 nm had lower penetration, resulting in a better qf for a given pressure drop. The values of qf,o, particularly for PM0.1, reveal that for the tested treatments and masks, physical decontamination methods are less destructive to the filter than chemical methods. Nevertheless, when purchasing new or reusing FFRs, penetration should be regarded as the priority.

Partner Notification for Youth Living with HIV in 14 Cities in the United States.[Pubmed: 29023252]

Identifying factors associated with partner notification among youth living with HIV is critical for effective HIV prevention and treatment strategies.


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