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11-Oxo-mogroside V

11-Oxo-mogroside V

Catalog No. BCN2509
Size Price Stock
10mg $218 In stock
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Quality Control of 11-Oxo-mogroside V

Chemical structure

11-Oxo-mogroside V

Biological Activity of 11-Oxo-mogroside V

1. 11 -oxo-mogroside V exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC50 = 3.09 microg/ml.
2. 11-Oxo-mogroside V exhibits the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

11-Oxo-mogroside V Dilution Calculator

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Chemical Properties of 11-Oxo-mogroside V

Cas No. 126105-11-1 SDF Download SDF
Type of Compound Triterpenoids Appearance Powder
Formula C60H100O29 M.Wt 1285.42
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 11-Oxo-mogroside V

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.778 mL 3.8898 mL 7.7796 mL 15.5591 mL 19.4489 mL
5 mM 0.1556 mL 0.778 mL 1.5559 mL 3.1118 mL 3.8898 mL
10 mM 0.0778 mL 0.389 mL 0.778 mL 1.5559 mL 1.9449 mL
50 mM 0.0156 mL 0.0778 mL 0.1556 mL 0.3112 mL 0.389 mL
100 mM 0.0078 mL 0.0389 mL 0.0778 mL 0.1556 mL 0.1945 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 11-Oxo-mogroside V

This product is isolated and purified from the fruits of Siraitia grosvenorii Swingle.

References on 11-Oxo-mogroside V

The antioxidant activities of natural sweeteners, mogrosides, from fruits of Siraitia grosvenori.[Pubmed: 17852496]


To search for antioxidant agents from natural resources, in this paper the in vitro antioxidant activities of two natural sweeteners, mogroside V and 11-Oxo-mogroside V isolated from the fruits of Siraitia grosvenori, were determined using chemiluminescence (CL). The results showed that these sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited significant inhibitory effects on reactive oxygen species (O2-, H2O2 and *OH) and DNA oxidative damage. 11-Oxo-mogroside V showed a higher scavenging effect on O2- (concentration at which 50% of chemiluminescence intensity is inhibited [EC50] =4.79 microg/ml) and H2O2 (EC50 = 16.52 microg/ml) than those of mogroside V. However, mogroside V was more effective in scavenging *OH, with EC50 =48.44 microg/ml compared with that of 11-Oxo-mogroside V (EC50 = 146.17 microg/ml). Further, 11-Oxo-mogroside V exhibited a remarkable inhibitory effect on *OH-induced DNA damage with EC50 = 3.09 microg/ml.

Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.[Pubmed: 12893428]


To search for cancer chemopreventive agents from natural resources, many phytochemicals and food additives have been screened. Consequently, two natural sweeteners, mogroside V and 11-Oxo-mogroside V isolated from the fruits of Momordica grosvenori, exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). These sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited the significant inhibitory effects on the two-stage carcinogenesis test of mouse skin tumors induced by peroxynitrite (ONOO-) as an initiator and TPA as a promoter. Further, 11-Oxo-mogroside V also exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

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