Search Site
Home >> Research Area >>Nature Products >> 11-Hydroxytephrosin


Catalog No. BCN4861
Size Price Stock
20mg $298 In stock
Related Products

Organizitions Citing Our Products recently


Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris

Quality Control of 11-Hydroxytephrosin

Chemical structure


Biological Activity of 11-Hydroxytephrosin

1. 11-Hydroxytephrosin inhibits NF-kappaB activity.

11-Hydroxytephrosin Dilution Calculator

Concentration (start)
Volume (start)
Concentration (final)
Volume (final)


11-Hydroxytephrosin Molarity Calculator



Chemical Properties of 11-Hydroxytephrosin

Cas No. 72458-85-6 SDF Download SDF
SMILES COc1cc2OC[C@H]3Oc4c5C=CC(C)(C)Oc5cc(O)c4C(=O)[C@@]3(O)c2cc1OC
Standard InChI InChI=1S/C23H22O8/c1-22(2)6-5-11-14(31-22)8-13(24)19-20(11)30-18-10-29-15-9-17(28-4)16(27-3)7-12(15)23(18,26)21(19)25/h5-9,18,24,26H,10H2,1-4H3/t18-,23-/m1/s1
Type of Compound Flavonoids Appearance Yellow powder
Formula C23H22O8 M.Wt 426.4
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 11-Hydroxytephrosin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3452 mL 11.7261 mL 23.4522 mL 46.9043 mL 58.6304 mL
5 mM 0.469 mL 2.3452 mL 4.6904 mL 9.3809 mL 11.7261 mL
10 mM 0.2345 mL 1.1726 mL 2.3452 mL 4.6904 mL 5.863 mL
50 mM 0.0469 mL 0.2345 mL 0.469 mL 0.9381 mL 1.1726 mL
100 mM 0.0235 mL 0.1173 mL 0.2345 mL 0.469 mL 0.5863 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 11-Hydroxytephrosin

This product is isolated and purified from the herbs of Derris robusta

References on 11-Hydroxytephrosin

Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.[Pubmed: 18841906]

NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation. Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new compounds, 5, 7, 8, and 9, and eight known compounds. Their structures were elucidated by spectroscopic methods. All compounds inhibited NF-kappaB activity, and tephrosin (1), 11-Hydroxytephrosin (2), and deguelin (3) were the most active, with IC50 values of 0.11, 0.19, and 0.22 microM, respectively, in TNF-alpha-stimulated HeLa cell-based reporter gene assays. Further investigations showed that compounds 1, 5, and 6 blocked NF-kappaB/DNA binding activity and suppressed the expression of NF-kappaB target genes.


11-Hydroxytephrosin ,72458-85-6,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

Online Inquiry

Fill out the information below

* Required Fields