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11(13)-Dehydroivaxillin

11(13)-Dehydroivaxillin

Catalog No. BCN4420
Size Price Stock
20mg $298 In stock
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Quality Control of 11(13)-Dehydroivaxillin

Chemical structure

11(13)-Dehydroivaxillin

Biological Activity of 11(13)-Dehydroivaxillin

1. 11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.

11(13)-Dehydroivaxillin Dilution Calculator

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Chemical Properties of 11(13)-Dehydroivaxillin

Cas No. 87441-73-4 SDF Download SDF
SMILES CC12CCC3OC3(C)CC4OC(=O)C(=C)C4CC1O2
Standard InChIKey SSZZFAJCDFWCJW-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H20O4/c1-8-9-6-12-14(2,19-12)5-4-11-15(3,18-11)7-10(9)17-13(8)16/h9-12H,1,4-7H2,2-3H3
Type of Compound Sesquiterpenoids Appearance Powder
Formula C15H20O4 M.Wt 264.3
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 11(13)-Dehydroivaxillin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7836 mL 18.9179 mL 37.8358 mL 75.6716 mL 94.5895 mL
5 mM 0.7567 mL 3.7836 mL 7.5672 mL 15.1343 mL 18.9179 mL
10 mM 0.3784 mL 1.8918 mL 3.7836 mL 7.5672 mL 9.4589 mL
50 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.5134 mL 1.8918 mL
100 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.7567 mL 0.9459 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 11(13)-Dehydroivaxillin

This product is isolated and purified from the herbs of Carpesium abrotanoides L.

References on 11(13)-Dehydroivaxillin

In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.[Pubmed: 18608780]


The whole plants of Carpesium genus are used in traditional medicine as anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. A previous study on Carpesium genus suggested that the antiplasmodial activity against Plasmodium falciparum was due to the existence of 11(13)-Dehydroivaxillin (DDV) from EtOAc extracts of C. ceruum (Compositae). Here, the antimalarial activity of 11(13)-Dehydroivaxillin was evaluated against Plasmodium berghei in mice. The LD(50) of the compound was determined as 51.2 mg/kg, while doses of 124 mg/kg and above were found to be lethal to mice. 11(13)-Dehydroivaxillin (2, 5, 10 mg/kg/day) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation and in an established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. 11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.

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