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10-Hydroxy-2-decenoic acid

10-Hydroxy-2-decenoic acid

Catalog No. BCN2654
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20mg $298 In stock
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Quality Control of 10-Hydroxy-2-decenoic acid

Chemical structure

10-Hydroxy-2-decenoic acid

Biological Activity of 10-Hydroxy-2-decenoic acid

1. 10-Hydroxy-2-decenoic acid could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions.
2. 10-Hydroxy-2-decenoic acid is a potential HDACI which inhibits the proliferation of FLS cells by PI3K-AKT pathway.
3. 10-Hydroxy-2-decenoic acid activates AMPK, and insulin independently enhances glucose uptake following translocation of Glut4 to PM.
4. 10-Hydroxy-2-decenoic acid activates AMPKα via extracellular Ca²⁺-dependent Ca²⁺/calmodulin-dependent kinase kinase β, without alteration in the AMP:ATP ratio, and liver kinase B1 was not involved in the activation.

10-Hydroxy-2-decenoic acid Dilution Calculator

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Chemical Properties of 10-Hydroxy-2-decenoic acid

Cas No. 765-01-5 SDF Download SDF
Chemical Name (E)-10-hydroxydec-2-enoic acid 10-hydroxydec-2-enoic acid
SMILES OCCCCCCCC=CC(O)=O
Standard InChIKey QHBZHVUGQROELI-SOFGYWHQSA-N
Standard InChI InChI=1S/C10H18O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h6,8,11H,1-5,7,9H2,(H,12,13)/b8-6+
Type of Compound Monoterpenoids Appearance Oil
Formula C10H18O3 M.Wt 186.24
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 10-Hydroxy-2-decenoic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.3694 mL 26.8471 mL 53.6942 mL 107.3883 mL 134.2354 mL
5 mM 1.0739 mL 5.3694 mL 10.7388 mL 21.4777 mL 26.8471 mL
10 mM 0.5369 mL 2.6847 mL 5.3694 mL 10.7388 mL 13.4235 mL
50 mM 0.1074 mL 0.5369 mL 1.0739 mL 2.1478 mL 2.6847 mL
100 mM 0.0537 mL 0.2685 mL 0.5369 mL 1.0739 mL 1.3424 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 10-Hydroxy-2-decenoic acid

This product is isolated and purified from the Royal jelly

References on 10-Hydroxy-2-decenoic acid

10-Hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates 5'-AMP-activated protein kinase in L6 myotubes and mice.[Pubmed: 23754629]


10-Hydroxy-2-decenoic acid (10H2DA) is one of the unique medium-chain fatty acids (MCFAs) specifically found in royal jelly. We hypothesize that 10-Hydroxy-2-decenoic acid has multiple biological functions and may aid in 5'-AMP-activated protein kinase (AMPK) activation and affect the glucose transport system in skeletal muscle. METHODS AND RESULTS: We examined whether various MCFAs present in royal jelly activated AMPKα. Treatment of L6 myotubes with various MCFAs showed that 10-Hydroxy-2-decenoic acid administration resulted in a significant increase in phosphorylated AMPKα. 10-Hydroxy-2-decenoic acid activates AMPK independently of insulin and significantly increased glucose uptake into L6 myotubes following translocation of glucose transporter 4 (Glut4) to the plasma membrane (PM).Oral administration of 10-Hydroxy-2-decenoic acid significantly stimulated phosphorylation of AMPK and Glut4 translocation to the PM in mouse skeletal muscle. CONCLUSION: These findings indicate that (i) 10-Hydroxy-2-decenoic acid activates AMPK, and insulin independently enhances glucose uptake following translocation of Glut4 to PM, (ii) activation of AMPKα by 10-Hydroxy-2-decenoic acid is mediated via extracellular Ca²⁺-dependent Ca²⁺/calmodulin-dependent kinase kinase β, without alteration in the AMP:ATP ratio, and liver kinase B1 was not involved in the activation.

10-Hydroxy-2-decenoic acid prevents ultraviolet A-induced damage and matrix metalloproteinases expression in human dermal fibroblasts.[Pubmed: 23030720]


BACKGROUND: 10-Hydroxy-2-decenoic acid (10-HDA) is a major fatty acid component of royal jelly, which has been reported to have a variety of beneficial pharmacological characteristics. However, the effects of 10-Hydroxy-2-decenoic acid on skin photoageing and its potential mechanism of action are unclear. OBJECTIVE: We investigated the protective effects of 10-Hydroxy-2-decenoic acid on ultraviolet (UV) A-induced damage in human dermal fibroblasts (HDFs). We then explored the inhibitory effects of 10-Hydroxy-2-decenoic acid on UVA-induced matrix metalloproteinases (MMPs) expression and elucidated the signalling pathways controlling MMPs inhibition. RESULTS: HDFs treated with 10-Hydroxy-2-decenoic acid were significantly protected from UVA-induced cytotoxicity, ROS, cellular senescence and stimulated collagen production. Moreover, 10-Hydroxy-2-decenoic acid suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels. Treatment with 10-Hydroxy-2-decenoic acid also reduced the UVA-induced activation of the JNK and p38 MAPK pathways. CONCLUSION: The data obtained in this study provide evidence that 10-Hydroxy-2-decenoic acid could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions. Therefore, 10-Hydroxy-2-decenoic acid may be a potential agent for the prevention and treatment of skin photoageing.

10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes by PI3K-AKT pathway.[Pubmed: 26050632]


To reveal the mechanism of 10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes (FLSs) of RA patients. Cell proliferation, HDAC activity and histone acetylation level of FLS cells treated with 10-Hydroxy-2-decenoic acid were detected by MTT assay, Colorimetric HDAC Activity Assay and Western-blot. Different genes in FLS cells from RA patients were primary cultured and treated with 10-Hydroxy-2-decenoic acid. They were then screened by Human Transcriptome 1.0 ST microarrays and verified by real-time PCR. The results showed dose-dependent and time-dependent decreases in cell viability and HDAC activity in FLSs treated with 10-Hydroxy-2-decenoic acid, and time-dependent induction in the acetylation of H3 and H4 at the same time. These results imply that 10-Hydroxy-2-decenoic acid is a potential HDACI which inhibits the proliferation of FLS cells by PI3K-AKT pathway.

10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells.[Pubmed: 18955252]


10-Hydroxy-2-decenoic acid (10HDA), a major fatty acid component of RJ, is known to have various pharmacological effects; its antitumor activity being especially noteworthy. However, the mechanism underlying this effect is unclear. We examined the effect of 10-Hydroxy-2-decenoic acid on VEGF-induced proliferation, migration and tube formation in human umbilical vein endothelial cells (HUVECs). Our findings showed that, 10-Hydroxy-2-decenoic acid at 20 microM or more significantly inhibited such proliferation, migration and tube formation. Similarly, 10 microM GM6001, a matrix metalloprotease inhibitor, prevented VEGF-induced migration and tube formation. These findings indicate that 10-Hydroxy-2-decenoic acid exerts an inhibitory effect on VEGF-induced angiogenesis, partly by inhibiting both cell proliferation and migration.

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10-Hydroxy-2-decenoic acid ,765-01-5,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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