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1-Oleoyl lysophosphatidic acid sodium saltActivates LPA receptor

1-Oleoyl lysophosphatidic acid sodium salt

Catalog No. BCC7792
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1mg $65.00 Ship Within 7 Days
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Quality Control of 1-Oleoyl lysophosphatidic acid sodium salt

Chemical structure

1-Oleoyl lysophosphatidic acid sodium salt

1-Oleoyl lysophosphatidic acid sodium salt Dilution Calculator

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1-Oleoyl lysophosphatidic acid sodium salt Molarity Calculator

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Chemical Properties of 1-Oleoyl lysophosphatidic acid sodium salt

Cas No. 325465-93-8 SDF Download SDF
Chemical Name 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
SMILES CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)[O-])O.[Na+]
Standard InChIKey XGRLSUFHELJJAB-JGSYTFBMSA-M
Standard InChI InChI=1S/C21H41O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26;/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);/q;+1/p-1/b10-9-;/t20-;/m1./s1
Formula C21H40NaO7P M.Wt 458.5
Solubility Soluble to 10 mM in phosphate buffered saline
Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1-Oleoyl lysophosphatidic acid sodium salt

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.181 mL 10.9051 mL 21.8103 mL 43.6205 mL 54.5256 mL
5 mM 0.4362 mL 2.181 mL 4.3621 mL 8.7241 mL 10.9051 mL
10 mM 0.2181 mL 1.0905 mL 2.181 mL 4.3621 mL 5.4526 mL
50 mM 0.0436 mL 0.2181 mL 0.4362 mL 0.8724 mL 1.0905 mL
100 mM 0.0218 mL 0.1091 mL 0.2181 mL 0.4362 mL 0.5453 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Background on 1-Oleoyl lysophosphatidic acid sodium salt

IC50: N/A

1-Oleoyl lysophosphatidic acid (LPA) is a naturally occurring phospholipid with various effects. LPA is widely distributed in many tissues. Similar to many other biomediators, LPA interacts with cells via specific cell surface receptors, such as G proteincoupled receptors, to induce biological effects.

In vitro: LPA could mediate signal transduction via Edg/LPA receptor, inducing the proliferation, migration, adhesion and antiapoptotic function of tumor cells. Additionally, LPA was found to elicit upregulation of VEGF, leading to an indirect influence on initiation and progression of malignancies. LPA could also stimulate matrix metalloproteinase secretion and tumor angiogenesis factor [1].

In vivo: LPA was tested for its vascular remodeling effect in a rat model of hypoxic pulmonary hypertension. Serum from animals in the hypoxic group showed higher chemoattractant properties toward rat primary lung fibroblasts, and such cell migration increase was prevented by the LPA receptor 1 and 3 antagonists. LPA also found to increase adhesive properties of human pulmonary artery endothelial cells, via the activation of LPA receptor 1 or 3 [1].

Clinical trial: Clinical retults showed that LPA concentration was significantly higher in pancreatic cancer patients. For diagnosis of pancreatic cancer, the sensitivity of LPA was 89.6% and the specificity 79. 4%. However, plasma LPA alteration had shown significant correlations with the tumor size, pathological stage, surrounding lymph nodes, as well as specific histopathological features [2].

References:
[1] Yongling G, Shaokai W, Chenjie T, Jinfei C, Shukui W, Xiufeng C, Guangmei L, Pin L.  Clinical evaluation on the determination of plasma lysophosphatidic acid concentration in Chinese human pancreatic cancer. International Journal of Hepatobiliary and Pancreatic Diseases 2011;1:6-12.
[2] Shlyonsky V,Naeije R,Mies F.  Possible role of lysophosphatidic acid in rat model of hypoxic pulmonary vascular remodeling. Pulm Circ.2014 Sep;4(3):471-81.

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