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Home >> Research Area >>Nature Products >> 1-Hydroxyrutaecarpine


Catalog No. BCN5709
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20mg $298 In stock
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Quality Control of 1-Hydroxyrutaecarpine

Chemical structure


Biological Activity of 1-Hydroxyrutaecarpine

1. 1-Hydroxyrutaecarpine exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.
2. 1-Hydroxyrutaecarpine exhibits antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 micrograms/ml.

1-Hydroxyrutaecarpine Dilution Calculator

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1-Hydroxyrutaecarpine Molarity Calculator



Chemical Properties of 1-Hydroxyrutaecarpine

Cas No. 53600-24-1 SDF Download SDF
SMILES c1ccc2c(c1)c3c([nH]2)-c4nc5c(cccc5O)c(=O)n4CC3
Standard InChI InChI=1S/C18H13N3O2/c22-14-7-3-5-12-15(14)20-17-16-11(8-9-21(17)18(12)23)10-4-1-2-6-13(10)19-16/h1-7,19,22H,8-9H2
Type of Compound Alkaloids Appearance Yellow powder
Formula C18H13N3O2 M.Wt 303.3
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1-Hydroxyrutaecarpine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2971 mL 16.4853 mL 32.9707 mL 65.9413 mL 82.4266 mL
5 mM 0.6594 mL 3.2971 mL 6.5941 mL 13.1883 mL 16.4853 mL
10 mM 0.3297 mL 1.6485 mL 3.2971 mL 6.5941 mL 8.2427 mL
50 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.3188 mL 1.6485 mL
100 mM 0.033 mL 0.1649 mL 0.3297 mL 0.6594 mL 0.8243 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1-Hydroxyrutaecarpine

This product is isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth.

References on 1-Hydroxyrutaecarpine

New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum.[Pubmed: 15931588]

Three new alkaloids, 7,8-dehydro-1-methoxyrutaecarpine, isodecarine, and 8-demethyloxychelerythrine, together with sixteen known compounds, norchelerythrine, oxychelerythrine, decarine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, rutaecarpine, 1-Hydroxyrutaecarpine, gamma-fagarine, skimmianine, (-)-matairesinol, (-)-isoarctigenin, (+)-epipinoresinol, d-sesamin, lupeol, canthin-6-one, and arnottianamide have been isolated from the root bark of Zanthoxylum integrifoliolum. The structures of these new compounds were determined through spectral analyses. Among the isolates, 7,8-dehydro-1-methoxyrutaecarpine, norchelerythrine, oxychelerythrine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, 1-Hydroxyrutaecarpine, gamma-fagarine, skimmianine, (-)-matairesinol, and canthin-6-one exhibited cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.

Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum.[Pubmed: 8657756]

Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-Hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of ca. 1-2 micrograms/ml.


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