1-Hydroxy-2-oxopomolic acidCAS# 217466-37-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 217466-37-0 | SDF | Download SDF |
| PubChem ID | 10625284 | Appearance | Powder |
| Formula | C30H46O6 | M.Wt | 502.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,2R,4aS,6aS,6aS,6bR,8aS,10R,12S,12aR,14bS)-1,10,12-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-11-oxo-3,4,5,6,6a,7,8,8a,10,12,13,14b-dodecahydro-2H-picene-4a-carboxylic acid | ||
| SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(C(C(=O)C(C5(C)C)O)O)C)C)C2C1(C)O)C)C(=O)O | ||
| Standard InChIKey | VBLIMTVKFVIDFU-PAZRJNPVSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Agrimonia pilosa
| Description | 1. 1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression. |
| Targets | PPAR | GLUT | Fatty Acid Synthase |
1-Hydroxy-2-oxopomolic acid Dilution Calculator
1-Hydroxy-2-oxopomolic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9893 mL | 9.9463 mL | 19.8926 mL | 39.7852 mL | 49.7315 mL |
| 5 mM | 0.3979 mL | 1.9893 mL | 3.9785 mL | 7.957 mL | 9.9463 mL |
| 10 mM | 0.1989 mL | 0.9946 mL | 1.9893 mL | 3.9785 mL | 4.9731 mL |
| 50 mM | 0.0398 mL | 0.1989 mL | 0.3979 mL | 0.7957 mL | 0.9946 mL |
| 100 mM | 0.0199 mL | 0.0995 mL | 0.1989 mL | 0.3979 mL | 0.4973 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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1beta-Hydroxy-2-oxopomolic acid isolated from Agrimonia pilosa extract inhibits adipogenesis in 3T3-L1 cells.[Pubmed:22687396]
Biol Pharm Bull. 2012;35(5):643-9.
In order to determine anti-adipogenic effect, this study investigated 1beta-hydroxy-2-oxopomolic acid (HOA) isolated from Agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor gamma (PPARgamma), CCAAT-enhancer-binding protein alpha (C/EBPalpha), glucose transporter 4 (GLUT4), adiponectin, adipocyte fatty acid-binding protein 2 (aP2), adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c (ADD1/SREBP1c), resistin, and fatty acid synthase (Fas) in 3T3-L1 preadipocyte. We demonstrated that HOA induced a significant decrease in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, HOA reduced the transcripitional activity of PPARgamma induced by troglitazone, a potent diabetes agent; it also suppressed expression of PPARgamma and C/EBPalpha protein levels. Our data suggest that HOA isolated from Agrimonia pilosa inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARgamma and C/EBPalpha expression.
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