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1-Dehydro-6-gingerdione

1-Dehydro-6-gingerdione

Catalog No. BCN3265
Size Price Stock
20mg $298 In stock
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Quality Control of 1-Dehydro-6-gingerdione

Chemical structure

1-Dehydro-6-gingerdione

Biological Activity of 1-Dehydro-6-gingerdione

1. 1-Dehydro-6-gingerdione is 5-HT1A receptor partial agonists.
2. 1-Dehydro-6-gingerdione has antioxidant and anti-inflammatory activities.
3. 1-Dehydro-6-gingerdione significantly suppresses the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion.

1-Dehydro-6-gingerdione Dilution Calculator

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Chemical Properties of 1-Dehydro-6-gingerdione

Cas No. 76060-35-0 SDF Download SDF
Chemical Name 1-(4-hydroxy-3-methoxyphenyl)dec-1-ene-3,5-dione
SMILES CCCCCC(=O)CC(=O)C=CC1=CC(=C(C=C1)O)OC
Standard InChIKey JUKHKHMSQCQHEN-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H22O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h7-11,20H,3-6,12H2,1-2H3
Type of Compound Phenols Appearance Powder
Formula C17H22O4 M.Wt 290.4
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1-Dehydro-6-gingerdione

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4435 mL 17.2176 mL 34.4353 mL 68.8705 mL 86.0882 mL
5 mM 0.6887 mL 3.4435 mL 6.8871 mL 13.7741 mL 17.2176 mL
10 mM 0.3444 mL 1.7218 mL 3.4435 mL 6.8871 mL 8.6088 mL
50 mM 0.0689 mL 0.3444 mL 0.6887 mL 1.3774 mL 1.7218 mL
100 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.6887 mL 0.8609 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1-Dehydro-6-gingerdione

This product is isolated and purified from the rhizomes of Zingber officinale Rosc.

References on 1-Dehydro-6-gingerdione

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.[Pubmed: 22868095]


Hexahydrocurcumin, 1-Dehydro-6-gingerdione, 6-dehydroshogaol and 6-shogaol were evaluated for their antioxidant and anti-inflammatory activities in the present study. The relative antioxidant potencies of ginger compounds decreased in similar order of 1-Dehydro-6-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7μM and 6-shogaol of 7μM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14μM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-Dehydro-6-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion. These results contribute to our theoretical understanding of the potential beneficial effects of consuming ginger as a food and/or dietary supplement.

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