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1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

Catalog No. BCN1388
Size Price Stock
20mg $298 In stock
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Quality Control of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

Chemical structure

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene Dilution Calculator

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Chemical Properties of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

Cas No. 63644-68-8 SDF Download SDF
Chemical Name 4-[(1E,4E)-5-(4-hydroxy-3-methoxyphenyl)penta-1,4-dienyl]-2-methoxyphenol
SMILES COC1=C(C=CC(=C1)C=CCC=CC2=CC(=C(C=C2)O)OC)O
Standard InChIKey NUITXMZDWYBZLK-YDFGWWAZSA-N
Standard InChI InChI=1S/C19H20O4/c1-22-18-12-14(8-10-16(18)20)6-4-3-5-7-15-9-11-17(21)19(13-15)23-2/h4-13,20-21H,3H2,1-2H3/b6-4+,7-5+
Type of Compound Phenols Appearance Powder
Formula C19H20O4 M.Wt 312.4
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.201 mL 16.0051 mL 32.0102 mL 64.0205 mL 80.0256 mL
5 mM 0.6402 mL 3.201 mL 6.402 mL 12.8041 mL 16.0051 mL
10 mM 0.3201 mL 1.6005 mL 3.201 mL 6.402 mL 8.0026 mL
50 mM 0.064 mL 0.3201 mL 0.6402 mL 1.2804 mL 1.6005 mL
100 mM 0.032 mL 0.1601 mL 0.3201 mL 0.6402 mL 0.8003 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

This product is isolated and purified from the rhizomes of Curcuma longa L.

References on 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene

Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.[Pubmed: 25068729 ]


Aminomethyl derivatives of 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one, designed as new cytotoxins, were synthesized and evaluated in terms of their cytotoxic activities. The compounds have low CC50 values in the low micromolar range against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells. In general, the average CC50 values of these compounds were higher towards HGF, HPC and HPLF non-malignant cells, which reveals the tumour-selectivity of these aminomethyl derivatives, Mannich bases. Using specific concentrations of compounds 4 and 6 caused cleavage of PARP1 in HSC-2 cells but not HGF cells, which may be a contributing factor to cytotoxicities and the tumour-selectivities.

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