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1,5-Anhydro-D-glucitol

1,5-Anhydro-D-glucitol

Catalog No. BCN2234
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20mg $298 In stock
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Quality Control of 1,5-Anhydro-D-glucitol

Chemical structure

1,5-Anhydro-D-glucitol

Biological Activity of 1,5-Anhydro-D-glucitol

1. 1,5-Anhydro-D-glucitol level might provide additional information to identify macroangiopathy of patients with type 2 diabetes, especially in those with excellent HbA1c levels.
2. Low 1,5-Anhydro-D-glucitol levels are associated with vascular endothelial dysfunction, suggests it is a potentially useful marker for vascular endothelial dysfunction.

1,5-Anhydro-D-glucitol Dilution Calculator

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Chemical Properties of 1,5-Anhydro-D-glucitol

Cas No. 154-58-5 SDF Download SDF
Chemical Name (2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol
SMILES OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O
Standard InChIKey MPCAJMNYNOGXPB-SLPGGIOYSA-N
Standard InChI InChI=1S/C6H12O5/c7-1-4-6(10)5(9)3(8)2-11-4/h3-10H,1-2H2/t3-,4+,5+,6+/m0/s1
Type of Compound Miscellaneous Appearance White cryst.
Formula C6H12O5 M.Wt 164.16
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,5-Anhydro-D-glucitol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.0916 mL 30.4581 mL 60.9162 mL 121.8324 mL 152.2904 mL
5 mM 1.2183 mL 6.0916 mL 12.1832 mL 24.3665 mL 30.4581 mL
10 mM 0.6092 mL 3.0458 mL 6.0916 mL 12.1832 mL 15.229 mL
50 mM 0.1218 mL 0.6092 mL 1.2183 mL 2.4366 mL 3.0458 mL
100 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2183 mL 1.5229 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on 1,5-Anhydro-D-glucitol

Association of reduced levels of serum 1,5-Anhydro-d-glucitol with carotid atherosclerosis in patients with type 2 diabetes.[Pubmed: 24560424]


BACKGROUND: HbA1c level represents mean blood glycemic control. 1,5-Anhydro-D-glucitol (1,5-AG) level reflects glycemic fluctuations, a strong risk factor for the development of macroangiopathy. The present study investigated the relationship between serum 1,5-AG levels and macroangiopathy in patients with type 2 diabetes. METHODS: A total of 115 consecutive patients with type 2 diabetes, aged 45-79 years, were included. HbA1c, 1,5-Anhydro-D-glucitol, and lipid profile were measured. Carotid maximum intima-media thickness (IMT) and plaque score (PS) were determined by carotid sonography. An 1,5-Anhydro-D-glucitol level < 14.2 μg/mL was used as a predictor of a post-challenge 2-h blood glucose level > 200 mg/dL. Patients were divided into four groups: A (n=32), HbA1c ≥ 6.5% and 1,5-Anhydro-D-glucitol<14.2 μg/mL; B (n=23), HbA1c ≥ 6.5% and 1,5-Anhydro-D-glucitol ≥ 14.2 μg/mL; C (n=24), HbA1c < 6.5% and 1,5-AG <14.2 μg/mL; and D (n=36), HbA1c < 6.5% and 1,5-Anhydro-D-glucitol ≥ 14.2 μg/mL. RESULTS: HbA1c level had significant positive correlation with IMT and PS. 1,5-AG level had a significant negative correlation with PS. PS was significantly higher in group C than in group D, but similar to that in group B. In multivariate analysis, HbA1c (β=0.27, p=0.03) and 1,5-AG (β=-0.24, P=0.04) were independent determinants of PS. CONCLUSIONS: 1,5-Anhydro-D-glucitol level might provide additional information to identify macroangiopathy of patients with type 2 diabetes, especially in those with excellent HbA1c levels.

Low levels of 1,5-anhydro-D-glucitol are associated with vascular endothelial dysfunction in type 2 diabetes.[Pubmed: 24924149]


BACKGROUND: Vascular endothelial dysfunction is involved in macrovascular disease progression in type 2 diabetes mellitus (T2DM). We reported previously that blood glucose fluctuations, as evaluated by continuous glucose monitoring (CGM), correlate with vascular endothelial function, serving as a marker of vascular endothelial function. However, the use of CGM is limited, suggesting the need for another marker of vascular endothelial function. Here, we investigated the relationship between vascular endothelial dysfunction and blood levels of 1,5-Anhydro-D-glucitol (1,5-AG), a marker of both postprandial hyperglycemia and fluctuations in blood glucose. METHODS: In 32 inpatients with T2DM and HbA1c less than 8.0%, the reactive hyperemia index (RHI), an index of vascular endothelial function, was determined by peripheral arterial tonometry. The relationships between RHI and 1,5-Anhydro-D-glucitol , blood glucose, lipid metabolism markers, and blood pressure, were examined. RESULTS: There was a strong correlation between 1,5-Anhydro-D-glucitol and natural logarithmic-scaled RHI (L_RHI) (r = 0.55; P = 0.001). However, there was no correlation between L_RHI and HbA1c, fasting blood glucose, IRI, LDL-C, HDL-C, TG, systolic blood pressure, or diastolic blood pressure. Multivariate analysis identified blood 1,5-Anhydro-D-glucitol levels to be the only significant and independent determinant of L_RHI. CONCLUSIONS: In T2DM with HbA1c <8.0%, low 1,5-Anhydro-D-glucitol levels were associated with vascular endothelial dysfunction, suggesting it is a potentially useful marker for vascular endothelial dysfunction.

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