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1,4-Dicaffeoylquinic acid

1,4-Dicaffeoylquinic acid

Catalog No. BCN5912
Size Price Stock
20mg $248 In stock
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Quality Control of 1,4-Dicaffeoylquinic acid

Chemical structure

1,4-Dicaffeoylquinic acid

Biological Activity of 1,4-Dicaffeoylquinic acid

1. 1,4-Dicaffeoylquinic acid has antioxidant activity.
2. 1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentrations.

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Chemical Properties of 1,4-Dicaffeoylquinic acid

Cas No. 1182-34-9 SDF Download SDF
Chemical Name 1,4-bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]-3,5-dihydroxycyclohexane-1-carboxylic acid 1,4-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-3,5-dihydroxycyclohexane-1-carboxylic acid
SMILES c1cc(c(cc1/C=C/C(=O)O[C@@H]2CC[C@]([C@H]([C@@H]2O)O)(C(=O)O)OC(=O)/C=C/c3ccc(c(c3)O)O)O)O
Standard InChI InChI=1S/C25H24O12/c26-15-5-1-13(11-17(15)28)3-7-20(30)36-19-9-10-25(24(34)35,23(33)22(19)32)37-21(31)8-4-14-2-6-16(27)18(29)12-14/h1-8,11-12,19,22-23,26-29,32-33H,9-10H2,(H,34,35)/b7-3+,8-4+/t19-,22-,23+,25+/m1/s1
Type of Compound Phenylpropanoids Appearance White powder
Formula C25H24O12 M.Wt 516.46
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,4-Dicaffeoylquinic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9363 mL 9.6813 mL 19.3626 mL 38.7252 mL 48.4065 mL
5 mM 0.3873 mL 1.9363 mL 3.8725 mL 7.745 mL 9.6813 mL
10 mM 0.1936 mL 0.9681 mL 1.9363 mL 3.8725 mL 4.8406 mL
50 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7745 mL 0.9681 mL
100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3873 mL 0.4841 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1,4-Dicaffeoylquinic acid

This product is isolated and purified from the flowerbud of Lonicera japonica Thunb.

References on 1,4-Dicaffeoylquinic acid

Inhibitory effect of medicinal plant-derived carboxylic acids on the human transporters hOAT1, hOAT3, hOATP1B1, and hOATP2B1.[Pubmed: 24636064]

In this study, uptake experiments were performed to assess the inhibitory effects of cinnamic acid, ferulic acid, oleanolic acid, deoxycholic acid, and cynarin(1,4-Dicaffeoylquinic acid ) on hOAT1, hOAT3, hOATP1B1, and hOATP2B1. After a drug-drug interaction (DDI) investigation, cinnamic acid, ferulic acid, deoxycholic acid, and cynarin(1,4-Dicaffeoylquinic acid ) were found and validated to inhibit hOAT1 in a competitive manner, and deoxycholic acid was found to be an inhibitor of all four transporters. The apparent 50% inhibitory concentrations of cinnamic acid, ferulic acid, deoxycholic acid, and cynarin(1,4-Dicaffeoylquinic acid ) were estimated to be 133.87, 3.69, 90.03 and 6.03 μmol·L(-1) for hOAT1, respectively. The apparent 50% inhibitory concentrations of deoxycholic acid were estimated to be 9.57 μmol·L(-1) for hOAT3, 70.54 μmol·L(-1) for hOATP1B1, and 168.27 μmol·L(-1) for hOATP2B1. Because cinnamic acid, ferulic acid, and cynarin are ingredients of food or food additives, the present study suggests there are new food-drug interactions to be disclosed.


1,4-Dicaffeoylquinic acid ,1182-34-9,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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