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1,3,6-Trihydroxy-5-methoxyxanthone

1,3,6-Trihydroxy-5-methoxyxanthone

Catalog No. BCN3454
Size Price Stock
20mg $298 In stock
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Quality Control of 1,3,6-Trihydroxy-5-methoxyxanthone

Chemical structure

1,3,6-Trihydroxy-5-methoxyxanthone

1,3,6-Trihydroxy-5-methoxyxanthone Dilution Calculator

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Chemical Properties of 1,3,6-Trihydroxy-5-methoxyxanthone

Cas No. 41357-84-0 SDF Download SDF
Chemical Name 1,3,6-trihydroxy-5-methoxyxanthen-9-one
SMILES COC1=C(C=CC2=C1OC3=CC(=CC(=C3C2=O)O)O)O
Standard InChIKey OIDDYVZHNYQRKQ-UHFFFAOYSA-N
Standard InChI InChI=1S/C14H10O6/c1-19-14-8(16)3-2-7-12(18)11-9(17)4-6(15)5-10(11)20-13(7)14/h2-5,15-17H,1H3
Type of Compound Xanthones Appearance Yellow powder
Formula C14H10O6 M.Wt 274.2
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,3,6-Trihydroxy-5-methoxyxanthone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.647 mL 18.2349 mL 36.4697 mL 72.9395 mL 91.1743 mL
5 mM 0.7294 mL 3.647 mL 7.2939 mL 14.5879 mL 18.2349 mL
10 mM 0.3647 mL 1.8235 mL 3.647 mL 7.2939 mL 9.1174 mL
50 mM 0.0729 mL 0.3647 mL 0.7294 mL 1.4588 mL 1.8235 mL
100 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.7294 mL 0.9117 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1,3,6-Trihydroxy-5-methoxyxanthone

This product is isolated and purified from the herbs of Canscora decussata

References on 1,3,6-Trihydroxy-5-methoxyxanthone

Synthesis and antitumor activity evaluation of a novel series of xanthone derivatives.[Pubmed: 25628155]


A natural xanthone, 1,3,6-Trihydroxy-5-methoxyxanthone, was totally synthesized for the first time by six steps in 31% overall yield. The xanthone skeleton was formed by a one-step synthesis in 80% yield, and five of its novel derivatives were also obtained by this approach. This synthetic strategy and all the derivatives could be further used for the preparation of other natural xanthones. All the xanthones were characterized by NMR and ESI-MS, and the cytotoxicity of these xanthones was evaluated against HepG2 and HT-29 cells, and the preliminary structure-activity relationship was evaluated from the results. It was proved that the presence of 3-OH group in the molecule is crucial for its biological activity, while the presence of substituents at C-5 and C-6 may also be beneficial.

Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.[Pubmed: 11842327]


Assay-guided fractionation of the ethanol extract of Tovomita krukovii resulted in the identification of four new xanthones (1 - 4) and ten known compounds (5 - 14). The structures of compounds 1 - 14 were determined by spectral data to be 3,5-dihydroxy-4-methoxyxanthone (1), 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (2), 1,3,5-trihydroxy-8-isoprenylxanthone (3), 1,5,7-trihydroxy-8-isoprenylxanthone (4), 1,3,7-trihydroxy-2-isoprenylxanthone (5), 1,5-dihydroxyxanthone (6), 1,6-dihydroxy-5-methoxyxanthone (7), 1,3,5-trihydroxyxanthone (8), 1,3,6-Trihydroxy-5-methoxyxanthone (9), 1,6-dihydroxy-3,5-dimethoxyxanthone (10), 1,3,7-trihydroxyxanthone (11), 3-geranyl-2,4,6-trihydroxybenzophenone (12), betulinic acid (13), and 3,4-dihydroxybenzoic acid (14). Compounds 2, 3, 12 and 13 showed inhibitory effects against Candida albicans secreted aspartic proteases (SAP) with IC50 values of 15 microg/ml, 25 microg/ml, 40 microg/ml, and 6.5 microg/ml, respectively, while the other compounds were inactive. In addition, compound 12 showed activity against C. albicans, C. neoformans, S. aureus and methicillin resistant S. aureus (MRS).

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