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1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

Catalog No. BCN1570
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20mg $298 In stock
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Quality Control of 1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

Chemical structure

1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one Dilution Calculator

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Chemical Properties of 1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

Cas No. 14254-96-7 SDF Download SDF
SMILES COc1ccc2c(c1)c(=O)c3c(o2)c(c(c(c3OC)OC)OC)OC
Standard InChIKey DHPUCRJALNWKKQ-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H18O7/c1-20-9-6-7-11-10(8-9)13(19)12-14(21-2)16(22-3)18(24-5)17(23-4)15(12)25-11/h6-8H,1-5H3
Type of Compound Xanthones Appearance Yellow powder
Formula C18H18O7 M.Wt 346.33
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8874 mL 14.4371 mL 28.8742 mL 57.7484 mL 72.1855 mL
5 mM 0.5775 mL 2.8874 mL 5.7748 mL 11.5497 mL 14.4371 mL
10 mM 0.2887 mL 1.4437 mL 2.8874 mL 5.7748 mL 7.2185 mL
50 mM 0.0577 mL 0.2887 mL 0.5775 mL 1.155 mL 1.4437 mL
100 mM 0.0289 mL 0.1444 mL 0.2887 mL 0.5775 mL 0.7219 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

This product is isolated and purified from the fruits of Garcinia mangostana L.

References on 1,2,3,4,7-Pentamethoxy-9H-xanthen-9-one

Structural and Functional State of Erythrocyte Membranes in Mice at Different Stages of Experimental Parkinson's Disease Induced by Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP).[Pubmed: 28382410]


We studied some structural and functional parameters of erythrocyte membranes in mice at the late presymptomatic and early symptomatic stages of experimental Parkinson's disease induced by administration of MPTP (hemolysis, microviscosity of different regions of the lipid bilayer, LPO intensity, activity of antioxidant enzymes, and kinetic properties of acetylcholinesterase). At the presymptomatic stage, significant deviations of the studied parameters from the normal were observed; they were similar in direction and magnitude to those in humans with Parkinson's disease. At the early symptomatic stage, most parameters tended to normal. Microviscosity of bulk lipids increased at the presymptomatic stage and decreased after appearance of clinical symptoms. This dynamics probably reflects activation of compensatory mechanisms aimed at inhibition of oxidative stress triggered by the development of the pathological process.

Synthesis, Characterization and Cytotoxicity of Substituted [1]Benzothieno[3,2-e][1,2,4]triazolo [4,3-a]pyrimidines.[Pubmed: 28380219]


A new series of 4-benzyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidines was synthesized motivated by the widely reported anticancer activity of thieno[2,3-d]pyrimidines and triazolothienopyrimidines. The in vitro cytotoxic activity of some selected compounds was evaluated against two human cell lines: prostate cancer (PC-3) and colon cancer (HCT-116). A preliminary study of the structure-activity relationship of the target compounds was discussed. Most of the synthesized compounds showed remarkable activity on the tested cell lines, while compound 16c had the highest potency against the PC-3 cell line with an IC50 of 5.48 μM compared to Doxorubicin (IC50 = 7.7 μM), the reference standard used in this study. On the other hand, 6c and 18c were the most active against HCT-116 (IC50 = 6.12 and 6.56 μM, respectively) relative to IC50 = 15.82 μM of the standard. Thus, some of the synthesized thienopyrimidine derivatives, specially 6c, 16c and 18c, have the potential to be developed into potent anticancer agents.

ZnBr2-Mediated oxidative spiro-bromocyclization of propiolamide for the synthesis of 3-bromo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione.[Pubmed: 28379277]


ZnBr2-Mediated oxidative spiro-bromocyclization of N-arylpropiolamide has been described herein for the synthesis of 3-bromo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione with high efficiency. One equivalent of water was introduced into the final product. The reaction efficiently proceeded at room temperature, and an excellent tolerance of functional groups was demonstrated. Under standard conditions, 3-bromo-1-oxaspiro[4.5]deca-3,6,9-triene-2,8-dione and 3-bromo-1-azaspiro[4.5]deca-3,6,9-trien-8-one were synthesized.

A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones.[Pubmed: 28379272]


A formal [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones was realized to furnish polycyclic indolines in good yields. This protocol proceeded smoothly under basic conditions, with high atom-economy and broad substrate scope.

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