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(S)-WAY 100135 dihydrochloride5-HT1A receptor antagonist,potent and selective

(S)-WAY 100135 dihydrochloride

Catalog No. BCC6993
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10mg $171.00 Ship Within 7 Days
50mg $721.00 Ship Within 7 Days
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Quality Control of (S)-WAY 100135 dihydrochloride

Chemical structure

(S)-WAY 100135 dihydrochloride

Biological Activity of (S)-WAY 100135 dihydrochloride

Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.

(S)-WAY 100135 dihydrochloride Dilution Calculator

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Chemical Properties of (S)-WAY 100135 dihydrochloride

Cas No. 149007-54-5 SDF Download SDF
Chemical Name (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride
SMILES CC(C)(C)NC(=O)C(CN1CCN(CC1)C2=CC=CC=C2OC)C3=CC=CC=C3.Cl.Cl
Standard InChIKey VJGZNBYDSDEOED-UHFFFAOYSA-N
Standard InChI InChI=1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H
Formula C24H33N3O2.2HCl M.Wt 468.47
Solubility Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming and to 10 mM in water with sonication
Storage Desiccate at +4°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (S)-WAY 100135 dihydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1346 mL 10.673 mL 21.3461 mL 42.6922 mL 53.3652 mL
5 mM 0.4269 mL 2.1346 mL 4.2692 mL 8.5384 mL 10.673 mL
10 mM 0.2135 mL 1.0673 mL 2.1346 mL 4.2692 mL 5.3365 mL
50 mM 0.0427 mL 0.2135 mL 0.4269 mL 0.8538 mL 1.0673 mL
100 mM 0.0213 mL 0.1067 mL 0.2135 mL 0.4269 mL 0.5337 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Background on (S)-WAY 100135 dihydrochloride

(S)-WAY 100135 dihydrochloride is a potent and selective antagonist of 5-HT1A receptor with IC50 value of 15 nM.

The 5-HT1A receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and mediates inhibitory neurotransmission.

(S)-WAY 100135 dihydrochloride is a potent and selective somatodendritic and postsynaptic 5-HT1A receptors antagonist. (+/-)-WAY100135 inhibited 5-HT1A receptor in the rat hippocampal with IC50 value of 34 nM [1].

In the murine elevated plus-maze test, (S)-WAY 100135 (10 mg/kg) exhibited anxiolytic-like effects [2]. In free feeding rats, WAY-100135 (3 mg/kg) significantly inhibited hyperphagia and the increased incidence of feeding induced by 8-OH-DPAT (0.1 mg/kg), which was mediated by somatodendritic 5-HT1A autoreceptor [3]. In rats, (S)-WAY 100135 (0.2, 1, 5 ug/ul) inhibited the impairment of choice accuracy induced by intrahippocampal scopolamine (3.75 ug/ul) in a dose-dependent way. However, (S)-WAY 100135 didn’t influence the acquisition of spatial learning [4]. In rats, WAY-100135 (10.0 mg/kg) inhibited the decrease of 5-HT release induced by buspirone, a 5-HT1A receptor partial agonist [5].

References:
[1].  Fletcher A, Bill DJ, Bill SJ, et al. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur J Pharmacol, 1993, 237(2-3): 283-291.
[2].  Rodgers RJ, Cole JC. Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur J Pharmacol, 1994, 261(3): 321-325.
[3].  Hartley JE, Fletcher A. The effects of WAY-100135 and 8-hydroxy-2-(di-n-propylamino)tetralin on feeding in the rat. Eur J Pharmacol, 1994, 252(3): 329-332.
[4].  Carli M, Luschi R, Samanin R. (S)-WAY 100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Eur J Pharmacol, 1995, 283(1-3): 133-139.
[5].  Routledge C, Gurling J, Ashworth-Preece MA, et al. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. Eur J Pharmacol, 1995, 276(3): 281-284.

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(S)-WAY 100135 dihydrochloride,149007-54-5,Neuroscience,5-HT Receptor, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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